EG12110A - Process for preparing of substituted 1,3-dihydrospiro(isobenzofuran) - Google Patents
Process for preparing of substituted 1,3-dihydrospiro(isobenzofuran)Info
- Publication number
- EG12110A EG12110A EG546/74A EG54674A EG12110A EG 12110 A EG12110 A EG 12110A EG 546/74 A EG546/74 A EG 546/74A EG 54674 A EG54674 A EG 54674A EG 12110 A EG12110 A EG 12110A
- Authority
- EG
- Egypt
- Prior art keywords
- dihydrospiro
- isobenzofuran
- substituted
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
- C07C43/1742—Unsaturated ethers containing halogen containing six-membered aromatic rings with halogen atoms bound to the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/45—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42411773A | 1973-12-12 | 1973-12-12 | |
| US05/502,650 US3959475A (en) | 1973-12-12 | 1974-09-03 | Substituted 1,3-dihydrospiro(isobenzofuran)s |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EG12110A true EG12110A (en) | 1981-03-31 |
Family
ID=27026243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EG546/74A EG12110A (en) | 1973-12-12 | 1974-12-11 | Process for preparing of substituted 1,3-dihydrospiro(isobenzofuran) |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3959475A (pl) |
| JP (1) | JPS5833876B2 (pl) |
| CA (1) | CA1051428A (pl) |
| CH (3) | CH617938A5 (pl) |
| DE (1) | DE2458177A1 (pl) |
| DK (1) | DK144214C (pl) |
| EG (1) | EG12110A (pl) |
| FI (1) | FI58128C (pl) |
| FR (1) | FR2254331B1 (pl) |
| GB (1) | GB1465999A (pl) |
| HU (1) | HU169546B (pl) |
| IE (1) | IE40298B1 (pl) |
| IL (1) | IL46201A (pl) |
| LU (1) | LU71461A1 (pl) |
| NL (1) | NL7416115A (pl) |
| NO (1) | NO146062C (pl) |
| OA (1) | OA04852A (pl) |
| SE (1) | SE419761B (pl) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024263A (en) * | 1975-04-30 | 1977-05-17 | American Hoechst Corporation | 1,3-Dihydrospiro[isobenzofuran-1,4'-piperidine]s |
| US3980786A (en) * | 1975-07-15 | 1976-09-14 | American Hoechst Corporation | 1,3-Dihydro-3-phenyl-1'-(2-propynyl)spiro[isobenzofuran]s |
| US3980787A (en) * | 1975-08-25 | 1976-09-14 | American Hoechst Corporation | 3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives |
| US3996354A (en) * | 1976-01-26 | 1976-12-07 | American Hoechst Corporation | 1,3-Dihydro-1'-dimethylphosphinylalkyl-3-phenylspiro(isobenzofuran)s |
| US4031224A (en) * | 1976-04-29 | 1977-06-21 | American Hoechst Corporation | 1,3-Dihydro-heteroarylspiro (isobenzofuran)s |
| US4241071A (en) * | 1977-01-27 | 1980-12-23 | American Hoechst Corporation | Antidepressant (α-phenyl-2-tolyl)azacycloalkanes |
| US4409229A (en) * | 1977-12-02 | 1983-10-11 | Hoechst-Roussel Pharmaceuticals, Inc. | Antidepressive and tranquilizing substituted 1,3-dihydrospiro[benzo(c)thiophene]s |
| EG13536A (en) * | 1977-12-02 | 1981-12-31 | Hoechst Ag | Substituted 1,3-dihydrospiro(benzo(c)thiophene)s |
| US4166119A (en) * | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines |
| US4166120A (en) * | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines |
| US4263317A (en) * | 1979-09-06 | 1981-04-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s |
| US4301292A (en) * | 1979-09-06 | 1981-11-17 | Hoechst-Roussel Pharmaceuticals, Incorporated | 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol |
| US4260623A (en) * | 1979-11-26 | 1981-04-07 | Warner-Lambert Company | Hexahydro-1-arylspiro(3H-oxazolo(3,4-A)pyridine-3,4'-piperidene) antidepressants, pharmaceutical compositions thereof and method of use thereof |
| US4268515A (en) * | 1980-02-04 | 1981-05-19 | Hoechst-Roussel Pharmaceuticals Inc. | Spiro[dihydrobenzofuran-piperidines and-pyrrolidines], pharmaceutical compositions thereof and methods of use thereof |
| US4304941A (en) * | 1980-08-01 | 1981-12-08 | Hoechst Roussel Pharmaceuticals, Inc. | Method of preparing poly-substituted acylbenzenes |
| US4404221A (en) * | 1981-10-19 | 1983-09-13 | Hoechst-Roussel Pharmaceuticals Inc. | 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use |
| US4517311A (en) * | 1981-10-19 | 1985-05-14 | Hoechst-Roussel Pharmaceuticals Inc. | 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions |
| US4524207A (en) * | 1981-10-20 | 1985-06-18 | Hoechst-Roussel Pharmaceuticals Inc. | Process for preparing substituted 1,3-dihydrospiro[benzo(c)thiophene]s |
| CA1315279C (en) * | 1987-01-12 | 1993-03-30 | Nancy Grace Bollinger | Anti-inflammatory agents |
| IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
| EP0450761A1 (en) * | 1990-03-02 | 1991-10-09 | Merck & Co. Inc. | Spirocyclic oxytocin antagonists |
| EP0445974A3 (en) * | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
| US5693643A (en) * | 1991-09-16 | 1997-12-02 | Merck & Co., Inc. | Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists |
| DE59308382D1 (de) * | 1992-11-29 | 1998-05-14 | Clariant Gmbh | Neue asymmetrische, halogenierte Benzophenone und Verfahren zu ihrer Herstellung |
| US6374762B1 (en) * | 1997-10-27 | 2002-04-23 | Correct Craft, Inc. | Water sport towing apparatus |
| US6433196B1 (en) * | 2000-02-17 | 2002-08-13 | Sumika Fine Chemicals Co., Ltd. | Production method of citalopram, intermediate therefor and production method of the intermediate |
| GB0213715D0 (en) * | 2002-06-14 | 2002-07-24 | Syngenta Ltd | Chemical compounds |
| KR20070046929A (ko) * | 2004-08-19 | 2007-05-03 | 버텍스 파마슈티칼스 인코포레이티드 | 무스카린 수용체 조절제 |
| US7786141B2 (en) * | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
| JP2008521825A (ja) | 2004-11-29 | 2008-06-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
| US8193208B2 (en) | 2005-09-09 | 2012-06-05 | Purdue Pharma L.P. | Fused and spirocycle compounds and the use thereof |
| EP1973543A2 (en) * | 2005-12-22 | 2008-10-01 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| WO2007100664A2 (en) * | 2006-02-22 | 2007-09-07 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| EP1987034B1 (en) * | 2006-02-22 | 2011-07-20 | Vertex Pharmceuticals Incorporated | Spiro condensed piperidines as modulators of muscarinic receptors |
| EP1847542A1 (en) * | 2006-04-21 | 2007-10-24 | Laboratorios del Dr. Esteve S.A. | Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor |
| CN101500565A (zh) * | 2006-06-29 | 2009-08-05 | 弗特克斯药品有限公司 | 毒蕈碱性受体的调节剂 |
| CN101553231A (zh) * | 2006-08-15 | 2009-10-07 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
| JP2010501561A (ja) * | 2006-08-18 | 2010-01-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体の調節剤 |
| AU2008307440A1 (en) * | 2007-10-03 | 2009-04-09 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| EP2563764B1 (en) * | 2010-04-26 | 2015-02-25 | Merck Sharp & Dohme Corp. | Novel spiropiperidine prolylcarboxypeptidase inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3686186A (en) * | 1970-10-05 | 1972-08-22 | William J Houlihan | Substituted isochroman or phthalan piperidenes |
-
1974
- 1974-09-03 US US05/502,650 patent/US3959475A/en not_active Expired - Lifetime
- 1974-12-06 IL IL7446201A patent/IL46201A/xx unknown
- 1974-12-09 DE DE19742458177 patent/DE2458177A1/de not_active Withdrawn
- 1974-12-10 FI FI3554/74A patent/FI58128C/fi active
- 1974-12-11 IE IE2648/74A patent/IE40298B1/xx unknown
- 1974-12-11 NL NL7416115A patent/NL7416115A/xx not_active Application Discontinuation
- 1974-12-11 DK DK644974A patent/DK144214C/da active
- 1974-12-11 EG EG546/74A patent/EG12110A/xx active
- 1974-12-11 NO NO744471A patent/NO146062C/no unknown
- 1974-12-11 CA CA215,786A patent/CA1051428A/en not_active Expired
- 1974-12-11 OA OA55362A patent/OA04852A/xx unknown
- 1974-12-11 SE SE7415521A patent/SE419761B/xx unknown
- 1974-12-11 HU HUHO1754A patent/HU169546B/hu unknown
- 1974-12-11 CH CH1647074A patent/CH617938A5/de not_active IP Right Cessation
- 1974-12-11 LU LU71461A patent/LU71461A1/xx unknown
- 1974-12-12 GB GB5374474A patent/GB1465999A/en not_active Expired
- 1974-12-12 FR FR7441005A patent/FR2254331B1/fr not_active Expired
- 1974-12-12 JP JP49142997A patent/JPS5833876B2/ja not_active Expired
-
1979
- 1979-09-05 CH CH800179A patent/CH619229A5/de not_active IP Right Cessation
- 1979-09-05 CH CH800079A patent/CH619228A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE7415521L (pl) | 1975-06-13 |
| LU71461A1 (pl) | 1976-11-11 |
| FR2254331A1 (pl) | 1975-07-11 |
| NO146062B (no) | 1982-04-13 |
| OA04852A (fr) | 1980-10-31 |
| FI355474A (pl) | 1975-06-13 |
| NO146062C (no) | 1982-08-11 |
| DK144214C (da) | 1982-06-21 |
| FI58128B (fi) | 1980-08-29 |
| IL46201A0 (en) | 1975-03-13 |
| FI58128C (fi) | 1980-12-10 |
| CA1051428A (en) | 1979-03-27 |
| CH619228A5 (pl) | 1980-09-15 |
| DK144214B (da) | 1982-01-18 |
| GB1465999A (en) | 1977-03-02 |
| NO744471L (pl) | 1975-07-07 |
| SE419761B (sv) | 1981-08-24 |
| DE2458177A1 (de) | 1976-09-30 |
| DK644974A (pl) | 1975-08-18 |
| NL7416115A (nl) | 1975-06-16 |
| JPS50100052A (pl) | 1975-08-08 |
| AU7624674A (en) | 1976-06-10 |
| IE40298B1 (en) | 1979-04-25 |
| FR2254331B1 (pl) | 1978-07-21 |
| CH617938A5 (pl) | 1980-06-30 |
| JPS5833876B2 (ja) | 1983-07-22 |
| US3959475A (en) | 1976-05-25 |
| HU169546B (pl) | 1976-12-28 |
| CH619229A5 (pl) | 1980-09-15 |
| IL46201A (en) | 1982-04-30 |
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