EE05306B1 - Arlitud furaan- ja tiofeenkarboksamiid, seda sisaldav ravimpreparaat ning hendi kasutamine kaaliumikanali blokaatorina toimiva ravimi valmistamiseks - Google Patents

Arlitud furaan- ja tiofeenkarboksamiid, seda sisaldav ravimpreparaat ning hendi kasutamine kaaliumikanali blokaatorina toimiva ravimi valmistamiseks

Info

Publication number
EE05306B1
EE05306B1 EEP200300240A EEP200300240A EE05306B1 EE 05306 B1 EE05306 B1 EE 05306B1 EE P200300240 A EEP200300240 A EE P200300240A EE P200300240 A EEP200300240 A EE P200300240A EE 05306 B1 EE05306 B1 EE 05306B1
Authority
EE
Estonia
Prior art keywords
thiophenecarboxamide
furan
evaluated
preparation
pharmaceutical formulation
Prior art date
Application number
EEP200300240A
Other languages
English (en)
Estonian (et)
Inventor
Peukert Stefan
Brendel Joachim
Hemmerle Horst
Kleemann Heinz-Werner
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of EE200300240A publication Critical patent/EE200300240A/xx
Publication of EE05306B1 publication Critical patent/EE05306B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200300240A 2000-12-12 2001-11-29 Arlitud furaan- ja tiofeenkarboksamiid, seda sisaldav ravimpreparaat ning hendi kasutamine kaaliumikanali blokaatorina toimiva ravimi valmistamiseks EE05306B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10061876A DE10061876A1 (de) 2000-12-12 2000-12-12 Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013958 WO2002048131A1 (fr) 2000-12-12 2001-11-29 Amides d'acides furane et thiophene carboxyliques aryles ayant un effet de blocage de canal de potassium

Publications (2)

Publication Number Publication Date
EE200300240A EE200300240A (et) 2003-08-15
EE05306B1 true EE05306B1 (et) 2010-06-15

Family

ID=7666837

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300240A EE05306B1 (et) 2000-12-12 2001-11-29 Arlitud furaan- ja tiofeenkarboksamiid, seda sisaldav ravimpreparaat ning hendi kasutamine kaaliumikanali blokaatorina toimiva ravimi valmistamiseks

Country Status (30)

Country Link
US (1) US6982279B2 (fr)
EP (1) EP1349846B1 (fr)
JP (1) JP4252798B2 (fr)
KR (1) KR20030061846A (fr)
CN (1) CN1225463C (fr)
AR (1) AR032781A1 (fr)
AT (1) ATE288906T1 (fr)
AU (2) AU2002235743B2 (fr)
BR (1) BR0116084A (fr)
CA (1) CA2431095A1 (fr)
CZ (1) CZ20031633A3 (fr)
DE (2) DE10061876A1 (fr)
DK (1) DK1349846T3 (fr)
EE (1) EE05306B1 (fr)
ES (1) ES2236335T3 (fr)
HK (1) HK1061850A1 (fr)
HR (1) HRP20030469A2 (fr)
HU (1) HUP0303665A3 (fr)
IL (2) IL156314A0 (fr)
MX (1) MXPA03004770A (fr)
NO (1) NO329163B1 (fr)
NZ (1) NZ526383A (fr)
PL (1) PL362410A1 (fr)
PT (1) PT1349846E (fr)
RS (1) RS50336B (fr)
RU (1) RU2275366C2 (fr)
SK (1) SK287464B6 (fr)
TW (1) TWI288134B (fr)
WO (1) WO2002048131A1 (fr)
ZA (1) ZA200304091B (fr)

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PL208713B1 (pl) * 2001-06-11 2011-05-31 Virochem Pharma Inc Związek stanowiący pochodną tiofenu, kompozycja farmaceutyczna zawierająca taki związek i jego zastosowanie
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
PT1569929E (pt) 2002-12-10 2010-06-18 Virochem Pharma Inc Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
EP1493739A1 (fr) * 2003-07-03 2005-01-05 Warner-Lambert Company LLC Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
EA016071B1 (ru) * 2005-05-13 2012-01-30 Вирокем Фарма Инк. Соединения и способы лечения или предотвращения флавивирусных инфекций
JP4943429B2 (ja) * 2005-07-22 2012-05-30 メルク・シャープ・エンド・ドーム・コーポレイション カリウムチャネル阻害剤
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
NZ572231A (en) * 2006-04-27 2010-12-24 Sanofi Aventis Deutschland Inhibitors of the task-1 and task-3 ion channel
RS52874B (en) 2006-11-15 2013-12-31 Vertex Pharmaceuticals Incorporated THYOPHEN ANALYSIS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
CA2699157A1 (fr) 2007-09-10 2009-03-19 Calcimedica, Inc. Composes modulant le calcium intracellulaire
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
WO2009076454A2 (fr) 2007-12-12 2009-06-18 Calcimedica, Inc. Compositions qui modulant le calcium intracellulaire
MX2011002149A (es) 2008-08-27 2011-04-05 Calcimedica Inc Compuestos que modulan el calcio intracelular.
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
JP2012516344A (ja) * 2009-01-30 2012-07-19 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 結晶質ｎ−｛（１ｓ）−２−アミノ−１−［（３−フルオロフェニル）メチル］エチル｝−５−クロロ−４−（４−クロロ−１−メチル−１ｈ−ピラゾール−５−イル）−２−チオフェンカルボキサミド塩酸塩
US8618307B2 (en) 2009-09-16 2013-12-31 Calcimedica, Inc. Compounds that modulate intracellular calcium
AU2011265047B2 (en) 2010-06-07 2014-10-23 Novomedix, Llc Furanyl compounds and the use thereof
US9079891B2 (en) 2010-08-27 2015-07-14 Calcimedica, Inc. Compounds that modulate intracellular calcium
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (fr) 2011-07-01 2018-04-28
EP2806865A1 (fr) 2012-01-27 2014-12-03 Gilead Sciences, Inc. Thérapies de combinaison à l'aide de bloqueurs de canaux ioniques au sodium tardifs et de bloqueurs de canaux ioniques au potassium
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN103012381B (zh) * 2013-01-10 2015-01-07 山东大学 苯基呋喃类化合物、其制备方法及在制备抗心律失常药物中的应用
KR101721490B1 (ko) * 2014-07-30 2017-03-30 한국생명공학연구원 페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물
EP3366683A1 (fr) * 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Amides, acetamides et ureas cycliques pour ouvris les voies de calcium

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GB9214120D0 (en) * 1991-07-25 1992-08-12 Ici Plc Therapeutic amides
DK41193D0 (da) * 1993-04-07 1993-04-07 Neurosearch As Ionkanalaabnere
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5670504A (en) 1995-02-23 1997-09-23 Merck & Co. Inc. 2,6-diaryl pyridazinones with immunosuppressant activity
US6083986A (en) 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors
US5935945A (en) 1996-10-31 1999-08-10 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US5969017A (en) 1996-10-31 1999-10-19 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US6013664A (en) * 1996-11-27 2000-01-11 Bayer Aktiengesellschaft Microbicidal agents based on thiophene-2-carboxylic acid derivatives
EP1003713A1 (fr) * 1997-08-05 2000-05-31 American Home Products Corporation Analogues d'acide anthranilique
NZ503809A (en) * 1997-12-19 2002-04-26 Schering Ag Ortho-anthranilamide derivatives as anti-coagulants
US6333337B1 (en) * 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
AU2300699A (en) * 1998-02-17 1999-08-30 Ono Pharmaceutical Co. Ltd. Amidino derivatives and drugs containing the same as the active ingredient
EP0960882A1 (fr) * 1998-05-19 1999-12-01 Hoechst Marion Roussel Deutschland GmbH Acylguanidines de thienyl et leur utilisation comme inhibiteurs de la résorptionosseuse et comme antagonistes du récepteur de la vitronectine
EP1082315A1 (fr) 1998-06-05 2001-03-14 Icagen, Inc. Inhibiteurs des canaux de potassium
AU754204B2 (en) 1998-09-01 2002-11-07 Bristol-Myers Squibb Company Potassium channel inhibitors and method
WO2000075129A1 (fr) * 1999-06-07 2000-12-14 Shire Biochem Inc. Inhibiteurs d'integrine thiophene
WO2003018585A1 (fr) * 2001-08-24 2003-03-06 Pharmacia & Upjohn Company Heteroaryl-7-aza[2.2.1]bicycloheptanes substitues destines au traitement de maladies

Also Published As

Publication number Publication date
JP4252798B2 (ja) 2009-04-08
HUP0303665A2 (hu) 2004-03-01
PT1349846E (pt) 2005-05-31
US6982279B2 (en) 2006-01-03
EP1349846B1 (fr) 2005-02-09
IL156314A (en) 2008-12-29
RU2275366C2 (ru) 2006-04-27
SK287464B6 (sk) 2010-10-07
HUP0303665A3 (en) 2005-02-28
NZ526383A (en) 2004-11-26
TWI288134B (en) 2007-10-11
JP2004526680A (ja) 2004-09-02
DE50105337D1 (de) 2005-03-17
BR0116084A (pt) 2003-10-14
NO20032535D0 (no) 2003-06-04
ZA200304091B (en) 2004-04-23
AR032781A1 (es) 2003-11-26
DE10061876A1 (de) 2002-06-20
RS50336B (sr) 2009-11-10
WO2002048131A1 (fr) 2002-06-20
YU42503A (sh) 2006-05-25
NO329163B1 (no) 2010-08-30
ES2236335T3 (es) 2005-07-16
PL362410A1 (en) 2004-11-02
ATE288906T1 (de) 2005-02-15
CA2431095A1 (fr) 2002-06-20
HRP20030469A2 (en) 2005-04-30
AU2002235743B2 (en) 2006-07-20
SK7252003A3 (en) 2003-12-02
NO20032535L (no) 2003-07-29
CZ20031633A3 (cs) 2003-08-13
CN1479734A (zh) 2004-03-03
AU3574302A (en) 2002-06-24
DK1349846T3 (da) 2005-05-30
US20040068120A1 (en) 2004-04-08
EE200300240A (et) 2003-08-15
KR20030061846A (ko) 2003-07-22
IL156314A0 (en) 2004-01-04
EP1349846A1 (fr) 2003-10-08
HK1061850A1 (en) 2004-10-08
CN1225463C (zh) 2005-11-02
MXPA03004770A (es) 2003-09-10

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20111129