EE04853B1 - Adenosiini derivaadid ja neid sisaldavad farmatseutilised kompositsioonid kasutamiseks meditsiinis - Google Patents

Adenosiini derivaadid ja neid sisaldavad farmatseutilised kompositsioonid kasutamiseks meditsiinis

Info

Publication number
EE04853B1
EE04853B1 EEP200000784A EEP200000784A EE04853B1 EE 04853 B1 EE04853 B1 EE 04853B1 EE P200000784 A EEP200000784 A EE P200000784A EE P200000784 A EEP200000784 A EE P200000784A EE 04853 B1 EE04853 B1 EE 04853B1
Authority
EE
Estonia
Prior art keywords
pharmaceutical compositions
compositions containing
medical use
adenosine derivatives
adenosine
Prior art date
Application number
EEP200000784A
Other languages
English (en)
Estonian (et)
Inventor
Peter Charles Cousins Richard
David Eldred Colin
Edmund Bays David
Joan Dyke Hazel
David Judkins Brian
Pass Martin
Michael Kenneth Pennell Andrew
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of EE200000784A publication Critical patent/EE200000784A/xx
Publication of EE04853B1 publication Critical patent/EE04853B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EEP200000784A 1998-06-23 1999-06-21 Adenosiini derivaadid ja neid sisaldavad farmatseutilised kompositsioonid kasutamiseks meditsiinis EE04853B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9813554.4A GB9813554D0 (en) 1998-06-23 1998-06-23 Chemical compounds
PCT/EP1999/004182 WO1999067262A1 (fr) 1998-06-23 1999-06-21 Derives d'adenosine

Publications (2)

Publication Number Publication Date
EE200000784A EE200000784A (et) 2002-04-15
EE04853B1 true EE04853B1 (et) 2007-06-15

Family

ID=10834247

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000784A EE04853B1 (et) 1998-06-23 1999-06-21 Adenosiini derivaadid ja neid sisaldavad farmatseutilised kompositsioonid kasutamiseks meditsiinis

Country Status (40)

Country Link
US (2) US6492348B1 (fr)
EP (2) EP1447407A1 (fr)
JP (2) JP3378240B2 (fr)
KR (1) KR100612797B1 (fr)
CN (2) CN1616459A (fr)
AP (1) AP2000002014A0 (fr)
AR (1) AR018917A1 (fr)
AT (1) ATE277941T1 (fr)
AU (1) AU758018B2 (fr)
BG (1) BG65064B1 (fr)
BR (1) BR9911498A (fr)
CA (1) CA2335520C (fr)
CO (1) CO5040216A1 (fr)
DE (1) DE69920697T2 (fr)
EA (1) EA003828B1 (fr)
EE (1) EE04853B1 (fr)
ES (1) ES2226399T3 (fr)
GB (1) GB9813554D0 (fr)
GE (1) GEP20032958B (fr)
HK (1) HK1034978A1 (fr)
HR (1) HRP20000896B1 (fr)
HU (1) HUP0102453A3 (fr)
ID (1) ID27484A (fr)
IL (2) IL140284A0 (fr)
IS (1) IS5773A (fr)
MY (1) MY122481A (fr)
NO (1) NO318788B1 (fr)
NZ (1) NZ508915A (fr)
OA (1) OA11574A (fr)
PE (1) PE20000704A1 (fr)
PL (1) PL194087B1 (fr)
PT (1) PT1090019E (fr)
RS (1) RS50042B (fr)
SI (1) SI1090019T1 (fr)
SK (1) SK19582000A3 (fr)
TR (1) TR200100449T2 (fr)
TW (1) TW541312B (fr)
UA (1) UA64794C2 (fr)
WO (1) WO1999067262A1 (fr)
ZA (1) ZA200007514B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9813554D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
WO2001064202A2 (fr) * 2000-03-01 2001-09-07 Euro-Celtique S.A. Traitement de troubles gastro-intestinaux fonctionnels
US20040162422A1 (en) * 2001-03-20 2004-08-19 Adrian Hall Chemical compounds
GB0106867D0 (en) * 2001-03-20 2001-05-09 Glaxo Group Ltd Process
GB0115178D0 (en) * 2001-06-20 2001-08-15 Glaxo Group Ltd Compounds
GB0115182D0 (en) * 2001-06-20 2001-08-15 Glaxo Group Ltd Medicaments
US6946449B2 (en) 2001-07-13 2005-09-20 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
US7713946B2 (en) 2002-07-11 2010-05-11 Cv Therapeutics, Inc. Partial and full agonists A1 adenosine receptors
US7157440B2 (en) 2001-07-13 2007-01-02 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
MXPA04008008A (es) 2002-02-19 2005-03-23 Cv Therapeutics Inc Agonistas parciales y completos de receptores de adenosina a1.
WO2003106475A2 (fr) * 2002-06-17 2003-12-24 Glaxo Group Limited Procede
DE60315164T2 (de) * 2002-08-15 2008-04-30 CV Therapeutics, Inc., Palo Alto Partielle und volle agonisten von a1-adenosinrezeptoren
WO2004055034A1 (fr) * 2002-12-18 2004-07-01 Glaxo Group Limited Polymorphe
WO2004055032A1 (fr) * 2002-12-18 2004-07-01 Glaxo Group Limited Derive d'adenosine present dans une forme v polymorphe
WO2004055033A1 (fr) * 2002-12-18 2004-07-01 Glaxo Group Limited Derive d'adenosine dans sa forme polymorphe iv
NZ541651A (en) 2003-02-03 2009-01-31 Cv Therapeutics Inc Partial and full agonists of A1 adenosine receptors
WO2005053712A1 (fr) * 2003-12-02 2005-06-16 Glaxo Group Limited Utilisation de derives d'adenosine aux fins de traitement de la dyslipidemie, de l'obesite, des facteurs de risque cardiovasculaire, du syndrome metabolique, du syndrome des ovaires polykystiques et du niddm
GT200500281A (es) * 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0607954D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
ES2440317T3 (es) * 2006-04-21 2014-01-28 Novartis Ag Derivados de purina para su uso como agonistas del receptor de adenosina A2A
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607953D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607950D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607948D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
EP1889846A1 (fr) 2006-07-13 2008-02-20 Novartis AG Dérivés de purine comme agonistes du recepteur A2a
EP1903044A1 (fr) * 2006-09-14 2008-03-26 Novartis AG Derivés de l'adénosine en tant qu' agonistes du récepteur A2A
AU2007316715A1 (en) * 2006-11-10 2008-05-15 Novartis Ag Cyclopentene diol monoacetate derivatives
US20090088403A1 (en) * 2007-05-07 2009-04-02 Randy Blakely A3 adenosine receptors as targets for the modulation of central serotonergic signaling
CN101712709A (zh) 2008-10-06 2010-05-26 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷及其调血脂的用途
EP2849566B1 (fr) * 2012-02-11 2018-04-04 Academia Sinica Analogues de l'adenosine destinées au traitement de la douleur
CR20170384A (es) 2015-02-24 2017-11-16 Pfizer Derivados de nucleosidos sustituidos utiles como agentes antineoplasicos
CN108864099A (zh) * 2018-09-08 2018-11-23 湖北荆洪生物科技股份有限公司 一种高纯6-糠氨基嘌呤的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962194A (en) * 1987-04-02 1990-10-09 Warner-Lambert Company Method of preparing 51,N6-disubstituted adenosines from inosines
US5646128A (en) * 1989-09-15 1997-07-08 Gensia, Inc. Methods for treating adenosine kinase related conditions
US5244896A (en) * 1990-09-14 1993-09-14 Marion Merrell Dow Inc. Carbocyclic adenosine analogs useful as immunosuppressants
DK62592D0 (fr) * 1992-05-14 1992-05-14 Novo Nordisk As
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
ATE176668T1 (de) * 1993-07-23 1999-02-15 Merrell Pharma Inc Neue 9-n-bicyclische nucleosidverbindungen nützlich als selektive inhibitoren von proinflammatorische cytokinen
AU3255097A (en) * 1996-07-05 1998-02-02 Novo Nordisk A/S Novel (n)-alkoxyadenine derivatives acting as cytokine inhibitors
UA51716C2 (uk) * 1996-07-08 2002-12-16 Авентіс Фармасьютікалз Продактс Інк. Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
AU4377397A (en) 1996-10-14 1998-05-11 Novo Nordisk A/S Novel therapeutically active adenosine derivatives
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
AR017457A1 (es) 1998-02-14 2001-09-05 Glaxo Group Ltd Compuestos derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol, procesos para su preparacion, composiciones que los contienen y su uso en terapia para el tratamiento de enfermedades inflamatorias.
GB9813554D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
EP1090019A1 (fr) 2001-04-11
EA003828B1 (ru) 2003-10-30
AR018917A1 (es) 2001-12-12
US6677316B2 (en) 2004-01-13
BR9911498A (pt) 2001-03-20
AU758018B2 (en) 2003-03-13
IL140284A (en) 2006-04-10
PE20000704A1 (es) 2000-08-03
IL140284A0 (en) 2002-02-10
GEP20032958B (en) 2003-04-25
ZA200007514B (en) 2002-01-23
ES2226399T3 (es) 2005-03-16
NO20006520L (no) 2001-02-14
JP2002518509A (ja) 2002-06-25
HUP0102453A3 (en) 2002-10-28
EP1447407A1 (fr) 2004-08-18
DE69920697D1 (de) 2004-11-04
WO1999067262A1 (fr) 1999-12-29
CA2335520A1 (fr) 1999-12-29
GB9813554D0 (en) 1998-08-19
RS50042B (sr) 2008-11-28
TR200100449T2 (tr) 2001-08-21
SK19582000A3 (sk) 2001-11-06
US20030096788A1 (en) 2003-05-22
CN1202118C (zh) 2005-05-18
PT1090019E (pt) 2005-01-31
AP2000002014A0 (en) 2000-12-31
ATE277941T1 (de) 2004-10-15
KR20010083067A (ko) 2001-08-31
UA64794C2 (en) 2004-03-15
JP3378240B2 (ja) 2003-02-17
EA200001222A1 (ru) 2001-08-27
CO5040216A1 (es) 2001-05-29
CN1616459A (zh) 2005-05-18
ID27484A (id) 2001-04-12
KR100612797B1 (ko) 2006-08-17
HRP20000896B1 (en) 2006-03-31
MY122481A (en) 2006-04-29
JP2003040891A (ja) 2003-02-13
CN1314910A (zh) 2001-09-26
TW541312B (en) 2003-07-11
HK1034978A1 (en) 2001-11-09
OA11574A (en) 2004-07-21
NO318788B1 (no) 2005-05-09
NO20006520D0 (no) 2000-12-20
PL194087B1 (pl) 2007-04-30
US6492348B1 (en) 2002-12-10
EP1090019B1 (fr) 2004-09-29
YU82800A (sh) 2003-04-30
PL345089A1 (en) 2001-12-03
DE69920697T2 (de) 2005-02-24
HRP20000896A2 (en) 2001-12-31
NZ508915A (en) 2003-09-26
EE200000784A (et) 2002-04-15
BG65064B1 (bg) 2007-01-31
BG105155A (en) 2001-09-28
SI1090019T1 (en) 2005-02-28
CA2335520C (fr) 2007-02-20
IS5773A (is) 2000-12-15
HUP0102453A2 (hu) 2002-04-29
AU4514699A (en) 2000-01-10

Similar Documents

Publication Publication Date Title
EE04853B1 (et) Adenosiini derivaadid ja neid sisaldavad farmatseutilised kompositsioonid kasutamiseks meditsiinis
EE200000168A (et) Karboksamidotiasoolderivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
EE9800028A (et) Iprotroopiumsoolad, neid sisaldavad ravimkompositsioonid ja nende kasutamine
EE200200149A (et) Kinasoliinühendid ja neid sisaldavad ravimkoostised
EE05181B1 (et) Prasolo[4,3-d]primidiini derivaadid, neid sisaldavad farmatseutilised kompositsioonid, nende kasutamine ja meetodid nende valmistamiseks
EE200000707A (et) Oksasolidinooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
EE200200138A (et) Kinolüülpropüülpiperidiini derivaadid, nende valmistamine ja neid sisaldavad kompositsioonid
EE04815B1 (et) 6,9-diasendatud-2-[trans-(4-aminotsükloheksüül)amino]puriinid, neid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine
EE04463B1 (et) 3-arüülpropaanhappe derivaadid ja nende analoogid, nende valmistamise meetod, neid sisaldavad ravimkoostised ja ühendid kasutamiseks ravis
EE05034B1 (et) Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid ja nende valmistamise meetodid
EE04354B1 (et) Indolüül-3-glüoksüülhappe derivaadid, nende kasutamine ravimite valmistamiseks ja neid sisaldavad kasvajavastase toimega ravimid
EE200000791A (et) Uudsed atsüülpseudopeptiidid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
EE04673B1 (et) Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
EE200200409A (et) 1,3-dihüdro-2H-indool-2-ooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
DE69924999D1 (de) Lipasehemmer enthaltende pharmazeutische zusammensetzungen
HUP0200588A2 (hu) Diarilszármazékok és azokat tartalmazó gyógyszerkészítmények és alkalmazásuk
EE04276B1 (et) Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
EE9800426A (et) Asendatud 2,4-tiasolidiindiooni derivaadid, nende valmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid
DK1057813T3 (da) Indolderivater og medicinske sammensætninger indeholdende de samme
EE200100027A (et) Fosfororgaanilised ühendid, neid sisaldav farmatseutiline preparaat ja nende kasutamine
EE04348B1 (et) Sahhariidderivaadid, neid sisaldav farmatseutiline kompositsioon ja nende kasutamine
EE200000429A1 (et) Sünteetilised polüsahhariidid, nende valmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid
EE05004B1 (et) Aminotiasooli derivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
EE9900426A (et) Püridiini uued derivaadid ja neid sisaldavad ravimkoostised
EE200200292A (et) Asendatud norbornüülaminoderivaadid, nende valmistamine ja kasutamine ravimitena või diagnostilisteainetena ning neid sisaldav ravim

Legal Events

Date Code Title Description
HK1A Erratum in gazette
KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090621