EE04061B1 - Metüleenbisfosfoonhappe derivaadid - Google Patents

Metüleenbisfosfoonhappe derivaadid

Info

Publication number
EE04061B1
EE04061B1 EEP200000239A EEP200000239A EE04061B1 EE 04061 B1 EE04061 B1 EE 04061B1 EE P200000239 A EEP200000239 A EE P200000239A EE P200000239 A EEP200000239 A EE P200000239A EE 04061 B1 EE04061 B1 EE 04061B1
Authority
EE
Estonia
Prior art keywords
acid derivatives
methylenebisphosphonic acid
methylenebisphosphonic
derivatives
acid
Prior art date
Application number
EEP200000239A
Other languages
English (en)
Estonian (et)
Inventor
Pohjala Esko
Veps�l�inen Jouko
Nupponen Heikki
K�hk�nen Jouni
Laur�n Leena
Hannuniemi Ritva
J�rvinen Tomi
Ahlmark Marko
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of EE200000239A publication Critical patent/EE200000239A/xx
Publication of EE04061B1 publication Critical patent/EE04061B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • C07F9/4093—Compounds containing the structure P(=X)-X-C(=X)- (X = O, S, Se)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EEP200000239A 1997-10-20 1998-10-20 Metüleenbisfosfoonhappe derivaadid EE04061B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI974001A FI104901B (fi) 1997-10-20 1997-10-20 Uudet metyleenibisfosfonihappojohdannaiset
PCT/FI1998/000814 WO1999020634A1 (en) 1997-10-20 1998-10-20 Novel methylenebisphosphonic acid derivatives

Publications (2)

Publication Number Publication Date
EE200000239A EE200000239A (et) 2001-08-15
EE04061B1 true EE04061B1 (et) 2003-06-16

Family

ID=8549759

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000239A EE04061B1 (et) 1997-10-20 1998-10-20 Metüleenbisfosfoonhappe derivaadid

Country Status (19)

Country Link
US (1) US6326363B1 (zh)
EP (1) EP1032578A1 (zh)
JP (1) JP2001520232A (zh)
KR (1) KR20010031269A (zh)
CN (1) CN1147497C (zh)
AU (1) AU740355B2 (zh)
BG (1) BG104452A (zh)
BR (1) BR9813102A (zh)
CA (1) CA2306080A1 (zh)
EE (1) EE04061B1 (zh)
FI (1) FI104901B (zh)
HU (1) HUP0004386A3 (zh)
IL (1) IL135639A0 (zh)
NO (1) NO20002006L (zh)
NZ (1) NZ504390A (zh)
PL (1) PL340055A1 (zh)
RU (1) RU2205833C2 (zh)
TR (1) TR200001055T2 (zh)
WO (1) WO1999020634A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO313180B1 (no) * 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
WO2008024169A1 (en) * 2006-07-21 2008-02-28 Glsynthesis, Inc. Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use
CA2747188C (en) 2008-11-20 2017-06-13 Glsynthesis Inc. Antithrombotic diadenosine tetraphosphates and related analogs
CN107011380A (zh) * 2016-01-28 2017-08-04 臧伟 一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447256A (en) 1977-07-20 1984-05-08 Nissan Chemical Industries, Ltd. N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same
DE2758580A1 (de) 1977-12-29 1979-07-05 Hoechst Ag Verfahren zur herstellung von phosphin- und phosphonsaeure-anhydriden
US4973576A (en) 1987-03-10 1990-11-27 Yamanouchi Pharmaceutical Co., Ltd. Bisphophonic acid derivatives and pharmaceutical compositions containing the same
US4933472A (en) 1988-04-08 1990-06-12 Yamanouchi Pharmaceutical Co., Ltd. Substituted aminomethylenebis(phosphonic acid) derivatives
EP0356866A3 (en) 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphorus-containing squalene synthetase inhibitors and method
FI83421C (fi) 1989-06-21 1991-07-10 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
DE69023844T2 (de) * 1989-09-06 1996-06-20 Merck & Co Inc Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.
FI89366C (fi) 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
FI89365C (fi) 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
FI89364C (fi) 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat
PL297372A1 (en) 1991-04-06 1993-09-06 Fisons Plc Atp analogs
TW237386B (zh) 1992-04-15 1995-01-01 Ciba Geigy
AU679721B2 (en) * 1993-02-10 1997-07-10 Astrazeneca Ab N-alkyl-2-substituted ATP analogues
US5462932A (en) 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations

Also Published As

Publication number Publication date
HUP0004386A2 (hu) 2001-04-28
JP2001520232A (ja) 2001-10-30
FI974001A (fi) 1999-04-21
NO20002006D0 (no) 2000-04-17
CN1147497C (zh) 2004-04-28
WO1999020634A1 (en) 1999-04-29
AU740355B2 (en) 2001-11-01
HUP0004386A3 (en) 2002-08-28
EE200000239A (et) 2001-08-15
NZ504390A (en) 2001-10-26
US6326363B1 (en) 2001-12-04
BG104452A (en) 2000-12-29
EP1032578A1 (en) 2000-09-06
NO20002006L (no) 2000-06-15
IL135639A0 (en) 2001-05-20
CN1276793A (zh) 2000-12-13
RU2205833C2 (ru) 2003-06-10
CA2306080A1 (en) 1999-04-29
KR20010031269A (ko) 2001-04-16
TR200001055T2 (tr) 2000-09-21
BR9813102A (pt) 2000-08-22
FI104901B (fi) 2000-04-28
FI974001A0 (fi) 1997-10-20
AU9543798A (en) 1999-05-10
PL340055A1 (en) 2001-01-15

Similar Documents

Publication Publication Date Title
ATE248812T1 (de) Arylsulfonylhydroxamsäurederivate
DK1003720T3 (da) Aryloxyarylsulfonylaminohydroxamsyrederivater
DE69703385D1 (de) Alkoxyessigsäure-derivate
NO990821D0 (no) Arylsulfonylamino-hydroksaminsyre-derivater
DK1005446T3 (da) N-aroylphenylalaninderivater
ATE235220T1 (de) Resorcinderivate
ID22781A (id) Turunan-turunan nikotinamida
ATE211131T1 (de) Arylsulfonylaminohydroxamsäurederivate
DE69817186D1 (de) Diaminorhodamin-derivate
EE04772B1 (et) 3-arüül-2-hüdroksüpropaanhappe derivaat (I)
ATE239005T1 (de) (4-sulfonylamino)-tetrahydropyran-4-carbonsäure hydroxamiden
ATE269861T1 (de) Substituierte indolalkansäure
PT915088E (pt) Derivados de d-prolina
DK1100769T3 (da) Aminomethylcarboxylsyrederivater
TR199802289A3 (tr) Fosfonasit-ikame etmis benzazepinon-n-asetikasit türevleri.
ATE255098T1 (de) Substituierte chromanderivate
PT1003719E (pt) Derivados microbicidas de n-sulfonil-glicinalquiniloxifenemetilamida
PT1027362E (pt) Derivados de cetolidos 2-halogeno-6-o-substituidos
IS5562A (is) Nýjar díhýdroxýhexanósýru afleiður
ATE440854T1 (de) 5-deoxy-cytidin-derivate
ATE255099T1 (de) Substituierte chromanderivate
DE69718338D1 (de) 3-alkoxyisoxazol-4-yl-substituierte 2-aminocarbonsäurederivate
DE69829682D1 (de) Cis-disubstituierte aminocycloalkyl-pyrrolidin-derivate
DE69811367D1 (de) Cis-substituierte fluoromethylpyrrolidin-derivate
DE69828780D1 (de) Amidinocamptpthecin-derivate

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

MM4A Lapsed by not paying the annual fees

Effective date: 20041020