ECSP11010947A - Compuestos n- sulfonamido pirazolil policíclicos - Google Patents

Compuestos n- sulfonamido pirazolil policíclicos

Info

Publication number
ECSP11010947A
ECSP11010947A EC2011010947A ECSP11010947A ECSP11010947A EC SP11010947 A ECSP11010947 A EC SP11010947A EC 2011010947 A EC2011010947 A EC 2011010947A EC SP11010947 A ECSP11010947 A EC SP11010947A EC SP11010947 A ECSP11010947 A EC SP11010947A
Authority
EC
Ecuador
Prior art keywords
compounds
formula
polychic
pirazolil
sulfonamide
Prior art date
Application number
EC2011010947A
Other languages
English (en)
Inventor
Andrei Konradi
Christopher M Semko
Xiacong Michael Ye
Ming Sun
Albert W Garofalo
Raymond A Ng
Gary Probst
Danielle L Aubele
Anh P Truong
Simeon Bowers
Darren Dressen
Michael S Dappen
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of ECSP11010947A publication Critical patent/ECSP11010947A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona compuestos teniendo una estructura de acuerdo a las Fórmulas 1, 2, 3 y 4: Fórmula 1 Fórmula 2Fórmula 3 Fórmula 4Donde el anillo-A, el anillo-B, el anillo-C, m, n, R25, R50, y R51 son como se describe en la especificación. La invención también proporciona composiciones farmacéuticas comprendiendo compuestos de las Fórmulas 1, 2, 3 y 4, así como también métodos para el tratamiento de desórdenes cognitivos, tales como la Enfermedad de Alzheimer. La invención además proporciona sustancias intermedias útiles en la preparación de los compuestos de las Fórmulas 1, 2, 3 y 4.
EC2011010947A 2008-09-05 2011-04-01 Compuestos n- sulfonamido pirazolil policíclicos ECSP11010947A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9479908P 2008-09-05 2008-09-05
US9924108P 2008-09-23 2008-09-23
US17327809P 2009-04-28 2009-04-28
US22653209P 2009-07-17 2009-07-17

Publications (1)

Publication Number Publication Date
ECSP11010947A true ECSP11010947A (es) 2011-07-29

Family

ID=41258775

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011010947A ECSP11010947A (es) 2008-09-05 2011-04-01 Compuestos n- sulfonamido pirazolil policíclicos

Country Status (20)

Country Link
US (1) US8283358B2 (es)
EP (1) EP2346863A2 (es)
JP (1) JP2012502051A (es)
KR (1) KR20110055715A (es)
CN (1) CN102203089A (es)
AR (1) AR073497A1 (es)
AU (1) AU2009289579A1 (es)
BR (1) BRPI0918213A2 (es)
CA (1) CA2736767A1 (es)
CL (1) CL2011000405A1 (es)
CO (1) CO6362008A2 (es)
EA (1) EA201170421A1 (es)
EC (1) ECSP11010947A (es)
IL (1) IL211263A0 (es)
MA (1) MA32688B1 (es)
MX (1) MX2011002047A (es)
PE (1) PE20110418A1 (es)
TW (1) TW201014856A (es)
WO (1) WO2010028213A2 (es)
ZA (1) ZA201101994B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9265734B2 (en) 2008-09-03 2016-02-23 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
PE20110418A1 (es) 2008-09-05 2011-06-22 Elan Pharm Inc Compuestos n-sulfonamido pirazolil policiclicos
PT2680694T (pt) 2011-02-28 2019-03-14 Biomarin Pharm Inc Inibidores de histona deacetilase
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
JP6503338B2 (ja) 2013-03-15 2019-04-17 バイオマリン ファーマシューティカル インコーポレイテッド Ｈｄａｃ阻害剤
KR20220123406A (ko) * 2020-01-03 2022-09-06 블루 오크 파마슈티컬스, 인코포레이티드 Cns 장애를 치료하기 위한 화합물 및 조성물
CN111909217B (zh) * 2020-08-20 2023-05-02 昆明贵金属研究所 一种双（二叔丁基-4-二甲氨基苯基膦）四溴双钯(ⅱ)化合物及其制备方法和用途
CN115448892B (zh) * 2022-09-19 2023-07-07 郑州铁路职业技术学院 一种苯并噻二唑杂环化合物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8727989D0 (en) * 1987-11-30 1988-01-06 Merck Sharp & Dohme Therapeutic agents
EP0330788A1 (en) 1988-03-01 1989-09-06 Merrell Dow Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmia
US20060035884A1 (en) * 2004-05-20 2006-02-16 Elan Pharmaceuticals, Inc. N-cyclic sulfonamido inhibitors of gamma secretase
CA2632670A1 (en) * 2005-08-19 2007-02-22 Elan Pharmaceuticals, Inc. Bridged n-cyclic sulfonamido inhibitors of gamma secretase
TW200813054A (en) * 2006-06-02 2008-03-16 Elan Pharm Inc Fused, tricyclic sulfonamide inhibitors of gamma secretase
CN101128035B (zh) 2006-08-18 2011-08-24 中兴通讯股份有限公司 时分码分多址系统中信道间的定时方法
CA2687765A1 (en) * 2007-05-25 2008-12-04 Elan Pharmaceuticals, Inc. Pyrazolopyrrolidines as inhibitors of gamma secretase
PE20110418A1 (es) 2008-09-05 2011-06-22 Elan Pharm Inc Compuestos n-sulfonamido pirazolil policiclicos

Also Published As

Publication number Publication date
MX2011002047A (es) 2011-06-17
EA201170421A1 (ru) 2012-01-30
MA32688B1 (fr) 2011-10-02
CL2011000405A1 (es) 2011-07-01
KR20110055715A (ko) 2011-05-25
US20100081680A1 (en) 2010-04-01
ZA201101994B (en) 2011-11-30
IL211263A0 (en) 2011-04-28
PE20110418A1 (es) 2011-06-22
CA2736767A1 (en) 2010-03-11
CN102203089A (zh) 2011-09-28
US8283358B2 (en) 2012-10-09
TW201014856A (en) 2010-04-16
JP2012502051A (ja) 2012-01-26
WO2010028213A2 (en) 2010-03-11
AU2009289579A1 (en) 2010-03-11
EP2346863A2 (en) 2011-07-27
BRPI0918213A2 (pt) 2015-12-08
CO6362008A2 (es) 2012-01-20
AR073497A1 (es) 2010-11-10
WO2010028213A3 (en) 2010-06-03

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