CO6362008A2 - Compuestos n- sulfonamido pirazolil policiclicos - Google Patents
Compuestos n- sulfonamido pirazolil policiclicosInfo
- Publication number
- CO6362008A2 CO6362008A2 CO11039494A CO11039494A CO6362008A2 CO 6362008 A2 CO6362008 A2 CO 6362008A2 CO 11039494 A CO11039494 A CO 11039494A CO 11039494 A CO11039494 A CO 11039494A CO 6362008 A2 CO6362008 A2 CO 6362008A2
- Authority
- CO
- Colombia
- Prior art keywords
- compounds
- pirazolil
- polyclic
- sulfonamide
- formulas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención proporciona compuestos teniendo una estructura de acuerdo a las Fórmulas 1, 2, 3 y 4:Donde el anillo-A, el anillo-B, el anillo-C, m, n, R25, R50, y R51 son como se describe en la especificación. La invención también proporciona composiciones farmacéuticas comprendiendo compuestos de las Fórmulas 1, 2, 3 y 4, así como también métodos para el tratamiento de desórdenes cognitivos, tales como la Enfermedad de Alzheimer. La invención además proporciona sustancias intermedias útiles en la preparación de los compuestos de las Fórmulas 1, 2, 3 y 4.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9479908P | 2008-09-05 | 2008-09-05 | |
US9924108P | 2008-09-23 | 2008-09-23 | |
US17327809P | 2009-04-28 | 2009-04-28 | |
US22653209P | 2009-07-17 | 2009-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6362008A2 true CO6362008A2 (es) | 2012-01-20 |
Family
ID=41258775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11039494A CO6362008A2 (es) | 2008-09-05 | 2011-03-31 | Compuestos n- sulfonamido pirazolil policiclicos |
Country Status (20)
Country | Link |
---|---|
US (1) | US8283358B2 (es) |
EP (1) | EP2346863A2 (es) |
JP (1) | JP2012502051A (es) |
KR (1) | KR20110055715A (es) |
CN (1) | CN102203089A (es) |
AR (1) | AR073497A1 (es) |
AU (1) | AU2009289579A1 (es) |
BR (1) | BRPI0918213A2 (es) |
CA (1) | CA2736767A1 (es) |
CL (1) | CL2011000405A1 (es) |
CO (1) | CO6362008A2 (es) |
EA (1) | EA201170421A1 (es) |
EC (1) | ECSP11010947A (es) |
IL (1) | IL211263A0 (es) |
MA (1) | MA32688B1 (es) |
MX (1) | MX2011002047A (es) |
PE (1) | PE20110418A1 (es) |
TW (1) | TW201014856A (es) |
WO (1) | WO2010028213A2 (es) |
ZA (1) | ZA201101994B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2330894B8 (en) | 2008-09-03 | 2017-04-19 | BioMarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
PE20110418A1 (es) | 2008-09-05 | 2011-06-22 | Elan Pharm Inc | Compuestos n-sulfonamido pirazolil policiclicos |
CA2828524C (en) | 2011-02-28 | 2020-01-07 | Repligen Corporation | Histone deacetylase inhibitors |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
JP6503338B2 (ja) | 2013-03-15 | 2019-04-17 | バイオマリン ファーマシューティカル インコーポレイテッド | Hdac阻害剤 |
CN114929235A (zh) * | 2020-01-03 | 2022-08-19 | 布鲁奥科制药有限公司 | 用于治疗cns病症的化合物和组合物 |
CN111909217B (zh) * | 2020-08-20 | 2023-05-02 | 昆明贵金属研究所 | 一种双(二叔丁基-4-二甲氨基苯基膦)四溴双钯(ⅱ)化合物及其制备方法和用途 |
CN115448892B (zh) * | 2022-09-19 | 2023-07-07 | 郑州铁路职业技术学院 | 一种苯并噻二唑杂环化合物的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8727989D0 (en) * | 1987-11-30 | 1988-01-06 | Merck Sharp & Dohme | Therapeutic agents |
EP0330788A1 (en) | 1988-03-01 | 1989-09-06 | Merrell Dow Pharmaceuticals Inc. | Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmia |
US20060035884A1 (en) * | 2004-05-20 | 2006-02-16 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
AU2006283567A1 (en) * | 2005-08-19 | 2007-03-01 | Elan Pharmaceuticals, Inc. | Bridged N-bicyclic sulfonamido inhibitors of gamma secretase |
TW200813054A (en) | 2006-06-02 | 2008-03-16 | Elan Pharm Inc | Fused, tricyclic sulfonamide inhibitors of gamma secretase |
CN101128035B (zh) | 2006-08-18 | 2011-08-24 | 中兴通讯股份有限公司 | 时分码分多址系统中信道间的定时方法 |
BRPI0812014A2 (pt) * | 2007-05-25 | 2014-11-18 | Elan Pharm Inc | Pirazolopirrolidinas como inibidores de gama secretase, composição farmacêutica compreendendo as mesmas e uso dos referidos compostos |
PE20110418A1 (es) | 2008-09-05 | 2011-06-22 | Elan Pharm Inc | Compuestos n-sulfonamido pirazolil policiclicos |
-
2009
- 2009-09-04 PE PE2011000438A patent/PE20110418A1/es not_active Application Discontinuation
- 2009-09-04 CA CA2736767A patent/CA2736767A1/en not_active Abandoned
- 2009-09-04 EP EP09792258A patent/EP2346863A2/en not_active Withdrawn
- 2009-09-04 JP JP2011526217A patent/JP2012502051A/ja active Pending
- 2009-09-04 KR KR1020117007863A patent/KR20110055715A/ko not_active Application Discontinuation
- 2009-09-04 MX MX2011002047A patent/MX2011002047A/es unknown
- 2009-09-04 AU AU2009289579A patent/AU2009289579A1/en not_active Abandoned
- 2009-09-04 WO PCT/US2009/055987 patent/WO2010028213A2/en active Application Filing
- 2009-09-04 BR BRPI0918213A patent/BRPI0918213A2/pt not_active IP Right Cessation
- 2009-09-04 TW TW098129931A patent/TW201014856A/zh unknown
- 2009-09-04 CN CN2009801426386A patent/CN102203089A/zh active Pending
- 2009-09-04 AR ARP090103413A patent/AR073497A1/es not_active Application Discontinuation
- 2009-09-04 EA EA201170421A patent/EA201170421A1/ru unknown
- 2009-09-04 US US12/554,134 patent/US8283358B2/en not_active Expired - Fee Related
-
2011
- 2011-02-17 IL IL211263A patent/IL211263A0/en unknown
- 2011-02-24 CL CL2011000405A patent/CL2011000405A1/es unknown
- 2011-03-16 ZA ZA2011/01994A patent/ZA201101994B/en unknown
- 2011-03-31 CO CO11039494A patent/CO6362008A2/es not_active Application Discontinuation
- 2011-04-01 EC EC2011010947A patent/ECSP11010947A/es unknown
- 2011-04-01 MA MA33737A patent/MA32688B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
PE20110418A1 (es) | 2011-06-22 |
MX2011002047A (es) | 2011-06-17 |
KR20110055715A (ko) | 2011-05-25 |
EA201170421A1 (ru) | 2012-01-30 |
CA2736767A1 (en) | 2010-03-11 |
JP2012502051A (ja) | 2012-01-26 |
IL211263A0 (en) | 2011-04-28 |
AU2009289579A1 (en) | 2010-03-11 |
EP2346863A2 (en) | 2011-07-27 |
MA32688B1 (fr) | 2011-10-02 |
ECSP11010947A (es) | 2011-07-29 |
TW201014856A (en) | 2010-04-16 |
CL2011000405A1 (es) | 2011-07-01 |
WO2010028213A3 (en) | 2010-06-03 |
US8283358B2 (en) | 2012-10-09 |
WO2010028213A2 (en) | 2010-03-11 |
BRPI0918213A2 (pt) | 2015-12-08 |
CN102203089A (zh) | 2011-09-28 |
ZA201101994B (en) | 2011-11-30 |
US20100081680A1 (en) | 2010-04-01 |
AR073497A1 (es) | 2010-11-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |