ECSP088901A - Método para preparar intermediarios de quinolina 4-halogenados - Google Patents

Método para preparar intermediarios de quinolina 4-halogenados

Info

Publication number
ECSP088901A
ECSP088901A EC2008008901A ECSP088901A ECSP088901A EC SP088901 A ECSP088901 A EC SP088901A EC 2008008901 A EC2008008901 A EC 2008008901A EC SP088901 A ECSP088901 A EC SP088901A EC SP088901 A ECSP088901 A EC SP088901A
Authority
EC
Ecuador
Prior art keywords
preparing
intermediaries
halogenated quinoline
formula
quinoline
Prior art date
Application number
EC2008008901A
Other languages
English (en)
Inventor
Chia-Cheng Shaw
Caroline Bernier
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP088901A publication Critical patent/ECSP088901A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)

Abstract

Esta invención se dirige a métodos para preparar compuestos de la fórmula (I):que comprende la etapa de hacer reaccionar un compuesto de la fórmula (II):con un reactivo de la fórmula POX3 y gel de sílice en una temperatura mayor de aproximadamente 75° C, y en donde las sustituciones en X, PG, A, G,R1 y R4 se establecen en la especificación.
EC2008008901A 2006-05-23 2008-11-21 Método para preparar intermediarios de quinolina 4-halogenados ECSP088901A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80275906P 2006-05-23 2006-05-23

Publications (1)

Publication Number Publication Date
ECSP088901A true ECSP088901A (es) 2008-12-30

Family

ID=38566902

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008901A ECSP088901A (es) 2006-05-23 2008-11-21 Método para preparar intermediarios de quinolina 4-halogenados

Country Status (19)

Country Link
US (1) US20070281932A1 (es)
EP (1) EP2027094A2 (es)
JP (1) JP2009538306A (es)
KR (1) KR20090010084A (es)
CN (1) CN101448790A (es)
AR (1) AR061098A1 (es)
AU (1) AU2007268058A1 (es)
CA (1) CA2651448A1 (es)
CR (1) CR10453A (es)
EC (1) ECSP088901A (es)
GT (1) GT200800255A (es)
IL (1) IL195111A0 (es)
MX (1) MX2008014899A (es)
NO (1) NO20084651L (es)
PE (1) PE20080098A1 (es)
RU (1) RU2008143595A (es)
TW (1) TW200808728A (es)
WO (1) WO2007139797A2 (es)
ZA (1) ZA200809964B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ556673A (en) 2005-02-03 2010-03-26 Gen Hospital Corp Method for treating gefitinib and/or erlotinib resistant cancer with an EGFR inhibitor
EP3488866A1 (en) 2005-11-04 2019-05-29 Wyeth LLC Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
ES2531322T3 (es) 2008-06-17 2015-03-13 Wyeth Llc Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina
EP3175853B1 (en) 2008-08-04 2023-11-01 Wyeth LLC Antineoplastic combinations of neratinib and capecitabine
PT3000467T (pt) 2009-04-06 2023-03-30 Wyeth Llc Regime de tratamento utilizando neratinib para o cancro de mama

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6288082B1 (en) * 1998-09-29 2001-09-11 American Cyanamid Company Substituted 3-cyanoquinolines
US6297258B1 (en) * 1998-09-29 2001-10-02 American Cyanamid Company Substituted 3-cyanoquinolines
US6533208B1 (en) * 1999-08-12 2003-03-18 Axis U.S.A., Inc. Winding cores with stratification motion
TWI275390B (en) * 2002-04-30 2007-03-11 Wyeth Corp Process for the preparation of 7-substituted-3- quinolinecarbonitriles
US7399865B2 (en) * 2003-09-15 2008-07-15 Wyeth Protein tyrosine kinase enzyme inhibitors
CN1930128A (zh) * 2004-01-16 2007-03-14 惠氏公司 受体酪氨酸激酶抑制剂的喹啉中间体及其合成

Also Published As

Publication number Publication date
NO20084651L (no) 2008-12-16
MX2008014899A (es) 2008-12-01
PE20080098A1 (es) 2008-03-31
GT200800255A (es) 2009-03-18
WO2007139797A2 (en) 2007-12-06
WO2007139797A3 (en) 2008-03-13
AU2007268058A1 (en) 2007-12-06
US20070281932A1 (en) 2007-12-06
CR10453A (es) 2009-01-07
IL195111A0 (en) 2009-09-22
EP2027094A2 (en) 2009-02-25
ZA200809964B (en) 2009-09-30
TW200808728A (en) 2008-02-16
AR061098A1 (es) 2008-08-06
RU2008143595A (ru) 2010-06-27
KR20090010084A (ko) 2009-01-28
JP2009538306A (ja) 2009-11-05
CN101448790A (zh) 2009-06-03
CA2651448A1 (en) 2007-12-06

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