ECSP077235A - Benzamidas sustituidas por trifluoro-metilo como inhibidores de quinasa - Google Patents
Benzamidas sustituidas por trifluoro-metilo como inhibidores de quinasaInfo
- Publication number
- ECSP077235A ECSP077235A EC2007007235A ECSP077235A ECSP077235A EC SP077235 A ECSP077235 A EC SP077235A EC 2007007235 A EC2007007235 A EC 2007007235A EC SP077235 A ECSP077235 A EC SP077235A EC SP077235 A ECSP077235 A EC SP077235A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- trifluoro
- methyl
- benzamids
- replaced
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 102000001253 Protein Kinase Human genes 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 229940127557 pharmaceutical product Drugs 0.000 abstract 2
- 108060006633 protein kinase Proteins 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical group NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0417905.7A GB0417905D0 (en) | 2004-08-11 | 2004-08-11 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP077235A true ECSP077235A (es) | 2007-03-29 |
Family
ID=33017336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2007007235A ECSP077235A (es) | 2004-08-11 | 2007-02-09 | Benzamidas sustituidas por trifluoro-metilo como inhibidores de quinasa |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20080096883A1 (enExample) |
| EP (1) | EP1778640A1 (enExample) |
| JP (1) | JP2008509187A (enExample) |
| KR (1) | KR20070046851A (enExample) |
| CN (2) | CN101039914A (enExample) |
| AU (1) | AU2005270313A1 (enExample) |
| BR (1) | BRPI0514288A (enExample) |
| CA (1) | CA2575316A1 (enExample) |
| EC (1) | ECSP077235A (enExample) |
| GB (1) | GB0417905D0 (enExample) |
| IL (1) | IL181169A0 (enExample) |
| MA (1) | MA28822B1 (enExample) |
| MX (1) | MX2007001642A (enExample) |
| NO (1) | NO20071300L (enExample) |
| RU (1) | RU2007108861A (enExample) |
| TN (1) | TNSN07048A1 (enExample) |
| WO (1) | WO2006015859A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070054916A1 (en) † | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| US7759337B2 (en) | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
| EP1878727A4 (en) * | 2005-04-28 | 2013-11-13 | Kyowa Hakko Kirin Co Ltd | 2-AMINOQUINAZOLINE DERIVATIVES |
| RU2452492C2 (ru) * | 2006-04-05 | 2012-06-10 | Новартис Аг | КОМБИНАЦИИ, ВКЛЮЧАЮЩИЕ ИНГИБИТОРЫ Bcr-Abl/c-Kit/PDGF-R TK, ДЛЯ ЛЕЧЕНИЯ РАКА |
| AU2007272533A1 (en) * | 2006-07-13 | 2008-01-17 | Novartis Ag | Use of trifluoromethyl substituted benzamides in the treatment of neurological disorders |
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US8673929B2 (en) * | 2006-07-20 | 2014-03-18 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
| AU2007293065B2 (en) * | 2006-09-05 | 2011-08-18 | Amgen Inc. | Phthalazine, AZA- and diaza-phthalazine compounds and methods of use |
| US20100173426A1 (en) * | 2006-12-19 | 2010-07-08 | Johnson Faye M | Biomaker identifying the reactivation of stat3 after src inhibition |
| ES2415863T3 (es) | 2006-12-22 | 2013-07-29 | Incyte Corporation | Heterociclos sustituidos como inhibidores de Janus Quinasas |
| US8022085B2 (en) * | 2007-05-07 | 2011-09-20 | Amgen Inc. | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof |
| AU2008248073B2 (en) * | 2007-05-07 | 2011-03-24 | Amgen Inc. | Pyrazolo-pyridinone compounds, process for their preparation, and their pharmaceutical use |
| US20100292292A1 (en) * | 2007-09-13 | 2010-11-18 | Link Medicine Corporation | Treatment of Neurodegenerative Diseases Using Indatraline Analogs |
| US8367671B2 (en) * | 2008-03-21 | 2013-02-05 | Amgen Inc. | Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents |
| US20110039845A1 (en) | 2008-04-23 | 2011-02-17 | Kyowa Hakko Kirin Co., Ltd. | 2-aminoquinazoline derivative |
| WO2010025201A1 (en) | 2008-08-29 | 2010-03-04 | Amgen Inc. | Pyridazino- pyridinone compounds for the treatment of protein kinase mediated diseases. |
| WO2010025202A1 (en) | 2008-08-29 | 2010-03-04 | Amgen Inc. | PYRIDO[3,2-d]PYRIDAZINE-2(1H)-ONE COMPOUNDS AS P38 MODULATORS AND METHODS OF USE THEREOF |
| US8497269B2 (en) | 2008-10-10 | 2013-07-30 | Amgen Inc. | Phthalazine compounds as p38 map kinase modulators and methods of use thereof |
| US8772481B2 (en) | 2008-10-10 | 2014-07-08 | Amgen Inc. | Aza- and diaza-phthalazine compounds as P38 map kinase modulators and methods of use thereof |
| CN102316738A (zh) * | 2009-02-18 | 2012-01-11 | 盛泰萨路申有限公司 | 作为激酶抑制剂的酰胺类 |
| EP2440053A4 (en) | 2009-06-09 | 2012-10-31 | California Capital Equity Llc | BENZYL SUBSTITUTED TRIAZINE DERIVATIVES AND THERAPEUTIC APPLICATIONS THEREOF |
| CA2765030C (en) | 2009-06-09 | 2015-10-27 | California Capital Equity, Llc | Triazine derivatives and their therapeutical applications |
| WO2010144586A1 (en) | 2009-06-09 | 2010-12-16 | Abraxis Bioscience, Llc | Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling |
| PH12012500809A1 (en) * | 2009-10-30 | 2012-11-26 | Ariad Pharma Inc | Methods and compositions for treating cancer |
| CN102675289B (zh) * | 2011-03-18 | 2014-11-05 | 浙江大德药业集团有限公司 | 作为蛋白激酶抑制剂的n-苯基苯甲酰胺衍生物 |
| EP2701507A1 (en) * | 2011-04-26 | 2014-03-05 | Merck Sharp & Dohme Corp. | Heterocyclic compounds as b-raf inhibitors for treatment of cancer |
| SG11201606876RA (en) | 2015-03-04 | 2016-10-28 | Gilead Sciences Inc | Toll like receptor modulator compounds |
| SI3507276T1 (sl) | 2016-09-02 | 2022-01-31 | Gilead Sciences, Inc. | Spojine modulatorja toličnih receptorjev |
| WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI879779B (zh) | 2019-06-28 | 2025-04-11 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
| CN111904960A (zh) * | 2020-05-19 | 2020-11-10 | 合肥合源药业有限公司 | 一种固体分散体及药用组合物 |
| KR102463217B1 (ko) * | 2020-07-13 | 2022-11-07 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 4-아미노퀴나졸린-2-카복스아미드 유도체 및 이를 포함하는 암의 예방, 개선 또는 치료용 약학 조성물 |
| CN111925331A (zh) * | 2020-07-14 | 2020-11-13 | 上海毕得医药科技有限公司 | 一种6-溴酞嗪的合成方法 |
| CN122167728A (zh) * | 2026-05-08 | 2026-06-09 | 苏州先觉生物科技有限公司 | 一种胶原拟肽及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6587829B1 (en) * | 1997-07-31 | 2003-07-01 | Schering Corporation | Method and apparatus for improving patient compliance with prescriptions |
| US6523009B1 (en) * | 1999-11-06 | 2003-02-18 | Bobbi L. Wilkins | Individualized patient electronic medical records system |
| US20030236682A1 (en) * | 1999-11-08 | 2003-12-25 | Heyer Charlette L. | Method and system for managing a healthcare network |
| US6684276B2 (en) * | 2001-03-28 | 2004-01-27 | Thomas M. Walker | Patient encounter electronic medical record system, method, and computer product |
| GB0217757D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
-
2004
- 2004-08-11 GB GBGB0417905.7A patent/GB0417905D0/en not_active Ceased
-
2005
- 2005-08-10 MX MX2007001642A patent/MX2007001642A/es not_active Application Discontinuation
- 2005-08-10 US US11/573,235 patent/US20080096883A1/en not_active Abandoned
- 2005-08-10 EP EP05777531A patent/EP1778640A1/en not_active Withdrawn
- 2005-08-10 JP JP2007525252A patent/JP2008509187A/ja active Pending
- 2005-08-10 RU RU2007108861/04A patent/RU2007108861A/ru not_active Application Discontinuation
- 2005-08-10 CN CNA200580034662XA patent/CN101039914A/zh active Pending
- 2005-08-10 CA CA002575316A patent/CA2575316A1/en not_active Abandoned
- 2005-08-10 BR BRPI0514288-1A patent/BRPI0514288A/pt not_active IP Right Cessation
- 2005-08-10 AU AU2005270313A patent/AU2005270313A1/en not_active Abandoned
- 2005-08-10 WO PCT/EP2005/008695 patent/WO2006015859A1/en not_active Ceased
- 2005-08-10 CN CN200910175026A patent/CN101696188A/zh active Pending
- 2005-08-10 KR KR1020077003238A patent/KR20070046851A/ko not_active Withdrawn
- 2005-08-10 US US11/201,348 patent/US20060035897A1/en not_active Abandoned
-
2007
- 2007-02-05 IL IL181169A patent/IL181169A0/en unknown
- 2007-02-09 TN TNP2007000048A patent/TNSN07048A1/en unknown
- 2007-02-09 EC EC2007007235A patent/ECSP077235A/es unknown
- 2007-02-22 MA MA29711A patent/MA28822B1/fr unknown
- 2007-03-09 NO NO20071300A patent/NO20071300L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL181169A0 (en) | 2007-07-04 |
| RU2007108861A (ru) | 2008-09-20 |
| NO20071300L (no) | 2007-04-19 |
| WO2006015859A1 (en) | 2006-02-16 |
| US20060035897A1 (en) | 2006-02-16 |
| BRPI0514288A (pt) | 2008-06-10 |
| MX2007001642A (es) | 2007-04-10 |
| GB0417905D0 (en) | 2004-09-15 |
| CA2575316A1 (en) | 2006-02-16 |
| KR20070046851A (ko) | 2007-05-03 |
| CN101039914A (zh) | 2007-09-19 |
| AU2005270313A1 (en) | 2006-02-16 |
| JP2008509187A (ja) | 2008-03-27 |
| EP1778640A1 (en) | 2007-05-02 |
| MA28822B1 (fr) | 2007-08-01 |
| TNSN07048A1 (en) | 2008-06-02 |
| CN101696188A (zh) | 2010-04-21 |
| US20080096883A1 (en) | 2008-04-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY30779A1 (es) | Derivados de dihidropiridina de utilidad como inhibidores de la proteina quinasa | |
| CR10072A (es) | Derivados de pirimidinil-aril-urea que son inhibidores de fgf | |
| CR8102A (es) | Derivados de pirazolo- quinazolina, procedimiento para preparacion y su uso como inhibidores de quinasa | |
| EA200901138A1 (ru) | Производные дианилинопиримидина как ингибиторы киназы wee1, фармацевтическая композиция и применение | |
| CR20110608A (es) | Derivados de 1h-imidazo-[4,5-c]-quinolinona | |
| DOP2010000013A (es) | Derivados de pirimidina trisustituida para el tratamiento de enfermedades proliferativas | |
| CR11614A (es) | Pirrolo[2,3-d]piridinas y usos de las mismas como inhibidores de cinasa de tirosina | |
| CR11201A (es) | Derivados de pirimidina trisustituida para el tratamiento de enfermedades proliferativas | |
| ECSP088973A (es) | Derivados de imidazol pirimidina para el tratamiento de enfermedades relacionadas con la glicógeno sintasa quinasa (gsk3) | |
| ECSP077324A (es) | Amidas bicíclicas como inhibidores de cinasa | |
| DOP2010000012A (es) | Derivados de morfolino pirimidina utilizados en enfermedades relacionadas con mtor quinasa y/o pi3k | |
| CR20110270A (es) | Piriloxi-indoles Inhibidores del VEGF-R2 y Uso de los Mismos para el Tratamiento de Enfermedades | |
| ECSP088821A (es) | Derivados de tioxantina y su uso como inhibidores de la mpo | |
| ECSP088329A (es) | Nuevos diazaespiroalcanos y su uso para el tratamiento de enfermedades mediadas por ccr8 | |
| CR8778A (es) | Revestimientos de azucar y metodos para estos | |
| CO2021002977A2 (es) | Dimetilaminoazetidinaminas como inhibidores de jak | |
| BRPI0514288A (pt) | benzamidas substituìdas com triflúor-metila como inibidores de cinases | |
| UY32190A (es) | Derivados de anilina-pirimidina sustituidos con sulfoximina como inhibdores de quinasas dependientes de ciclina (cdk), produccion y uso de los mismos como productos medicinales | |
| CO6630193A2 (es) | Inhibidores de la actividad de la proteína tirosina quinasa seleccionada | |
| UY32829A (es) | Derivados de 3-heteroaril-metil-imidazo-[1,2-b]-pirididazin - 6 -ilo | |
| ATE496899T1 (de) | Tetrahydro- und dihydrochinazolinone | |
| UY28993A1 (es) | Tetrahidroisoquinolinas sustituidas en calidad de inhibidores de mpm, procedimiento para su uso como medicamento.- | |
| UY28460A1 (es) | Compuestos de aminotriazol útiles como inhibidores de quinasas de proteinas | |
| CU23596A3 (es) | Derivados de pirazol-quinazolina y proceso para su preparación | |
| CR9323A (es) | TIAZOLIDINONAS COMO INHIBIDORAS DE LAS POLOQUINASAS (Plk) COMO MEDICAMENTO |