EA202191764A1 - Замещенные оксопиридиновые производные - Google Patents

Замещенные оксопиридиновые производные

Info

Publication number
EA202191764A1
EA202191764A1 EA202191764A EA202191764A EA202191764A1 EA 202191764 A1 EA202191764 A1 EA 202191764A1 EA 202191764 A EA202191764 A EA 202191764A EA 202191764 A EA202191764 A EA 202191764A EA 202191764 A1 EA202191764 A1 EA 202191764A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oxopyridine derivatives
substituted oxopyridine
substituted
derivatives
preparation
Prior art date
Application number
EA202191764A
Other languages
English (en)
Russian (ru)
Inventor
Зузанне Рёхриг
Зебастиан Эссиг
Паскаль Эллерброкк
Зоня Анлауф
Томас Неубауэр
Александер Хиллиш
Катарина Майер
Штефан Найтмайер
Адриан Терстееген
Мартина Шефер
Ян Штампфусс
Дитер Ланг
Хонгпинг Ванг
Цзэнцян Цзоу
Сянхай Мэн
Керстен Маттиас Герике
Original Assignee
Байер Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байер Акциенгезельшафт filed Critical Байер Акциенгезельшафт
Publication of EA202191764A1 publication Critical patent/EA202191764A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EA202191764A 2018-12-21 2019-12-18 Замещенные оксопиридиновые производные EA202191764A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2018122825 2018-12-21
PCT/EP2019/085983 WO2020127504A1 (en) 2018-12-21 2019-12-18 Substituted oxopyridine derivatives

Publications (1)

Publication Number Publication Date
EA202191764A1 true EA202191764A1 (ru) 2021-10-22

Family

ID=69143542

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202191764A EA202191764A1 (ru) 2018-12-21 2019-12-18 Замещенные оксопиридиновые производные

Country Status (22)

Country Link
EP (1) EP3898633A1 (de)
JP (1) JP2022514303A (de)
KR (1) KR20210106504A (de)
CN (1) CN113474348A (de)
AR (1) AR117435A1 (de)
AU (1) AU2019407909B2 (de)
BR (1) BR112021009435A2 (de)
CA (1) CA3124220A1 (de)
CL (1) CL2021001613A1 (de)
CO (1) CO2021007908A2 (de)
CR (1) CR20210342A (de)
DO (1) DOP2021000128A (de)
EA (1) EA202191764A1 (de)
EC (1) ECSP21043895A (de)
IL (1) IL283990A (de)
JO (1) JOP20210161A1 (de)
MA (1) MA54521A (de)
MX (1) MX2021007508A (de)
PE (1) PE20211790A1 (de)
SG (1) SG11202104384PA (de)
TW (1) TW202039510A (de)
WO (1) WO2020127504A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111770917B (zh) * 2018-03-15 2023-09-26 拜耳股份公司 两种化合物的制备方法
CN114105881B (zh) 2020-08-31 2024-01-26 沈阳海诺威医药科技有限公司 血小板聚集抑制剂及其制备方法和用途
MX2023010629A (es) 2021-03-09 2023-09-19 Bayer Ag Formas de dosificacion farmaceuticas que comprenden (4s)-24-cloro-4-etil-7?-fluoro-35-metoxi-3?,5-dioxo-14-(trifluoro metil)-3?h-6-aza-3(4,1)-piridina-1(1)-[1,2,3]triazola-2(1,2),7(1) -dibencenaheptafano-74-carboxamida.
BR112023016298A2 (pt) 2021-03-09 2023-10-03 Bayer Ag Formas cristalinas de (4s)-24-cloro-4-etil-73-fluoro-35-metóxi-32,5-dioxo-14-(trifluoro-metil)-32h-6-aza-3(4,1)-piridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzena-heptafano-74-carboxamida
WO2022189280A1 (en) 2021-03-09 2022-09-15 Bayer Aktiengesellschaft Solvates of (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5-dioxo-14-(trifluoro-methyl)-32 h-6- aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide
CN114560754A (zh) * 2022-02-25 2022-05-31 滁州学院 一种烷基醇的制备方法
CN116874469B (zh) * 2023-09-06 2023-11-10 成都施贝康生物医药科技有限公司 一种氧代吡啶类化合物、中间体及其制备方法和用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
DE102006032824A1 (de) * 2006-07-14 2008-01-17 Bayer Healthcare Ag Substituierte Indazole
EP2091947A2 (de) 2006-12-20 2009-08-26 Takeda San Diego, Inc. Glucokinaseaktivatoren
WO2014160592A2 (en) 2013-03-27 2014-10-02 Merck Sharp & Dohme Corp. FACTOR XIa INHIBITORS
TWI633089B (zh) * 2013-03-28 2018-08-21 拜耳製藥股份有限公司 經取代的酮基吡啶衍生物
EP3024822B1 (de) 2013-07-23 2017-05-03 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate und ihre verwendung als faktor xia und plasmakallikrein inhibitoren
JP6368367B2 (ja) 2013-10-30 2018-08-01 バイエル ファーマ アクチエンゲゼルシャフト 置換オキソピリジン誘導体
ES2722423T3 (es) * 2014-09-24 2019-08-12 Bayer Pharma AG Derivados de oxopiridina sustituidos
ES2712886T3 (es) * 2014-09-24 2019-05-16 Bayer Pharma AG Derivados de piridobenzazepina y piridobenzazocina que inhiben el factor XIa
ES2713624T3 (es) 2014-09-24 2019-05-23 Bayer Pharma AG Derivados de oxopiridina sustituidos
EP3197872B1 (de) 2014-09-24 2019-01-30 Bayer Pharma Aktiengesellschaft (2h)-2-oxopyridine als faktor xia-inhibitoren zur behandlung von thrombotischen erkrankungen
ES2694189T3 (es) 2014-09-24 2018-12-18 Bayer Pharma Aktiengesellschaft Derivados de oxopiridina sustituidos
EP3197880B1 (de) 2014-09-24 2018-10-24 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate mit anti-inflammatorischer und anti-thrombotischer wirkung
CN107428689A (zh) * 2015-03-19 2017-12-01 拜耳制药股份公司 作为治疗血栓形成的因子xia抑制剂的氧代吡啶衍生物
JO3703B1 (ar) 2015-07-09 2021-01-31 Bayer Pharma AG مشتقات أوكسوبيريدين مستبدلة
WO2017037051A1 (de) 2015-09-04 2017-03-09 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate

Also Published As

Publication number Publication date
AU2019407909B2 (en) 2023-05-25
CO2021007908A2 (es) 2021-07-19
IL283990A (en) 2021-07-29
DOP2021000128A (es) 2021-09-30
TW202039510A (zh) 2020-11-01
KR20210106504A (ko) 2021-08-30
ECSP21043895A (es) 2021-07-30
CR20210342A (es) 2021-08-09
PE20211790A1 (es) 2021-09-09
JOP20210161A1 (ar) 2023-01-30
CA3124220A1 (en) 2020-06-25
MA54521A (fr) 2022-03-30
AU2019407909A1 (en) 2021-05-27
SG11202104384PA (en) 2021-05-28
BR112021009435A2 (pt) 2021-08-17
CL2021001613A1 (es) 2021-12-03
JP2022514303A (ja) 2022-02-10
AR117435A1 (es) 2021-08-04
WO2020127504A1 (en) 2020-06-25
EP3898633A1 (de) 2021-10-27
CN113474348A (zh) 2021-10-01
MX2021007508A (es) 2021-08-05

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