MX2021007508A - Derivados de oxopiridina sustituidos. - Google Patents

Derivados de oxopiridina sustituidos.

Info

Publication number
MX2021007508A
MX2021007508A MX2021007508A MX2021007508A MX2021007508A MX 2021007508 A MX2021007508 A MX 2021007508A MX 2021007508 A MX2021007508 A MX 2021007508A MX 2021007508 A MX2021007508 A MX 2021007508A MX 2021007508 A MX2021007508 A MX 2021007508A
Authority
MX
Mexico
Prior art keywords
oxopyridine derivatives
substituted oxopyridine
substituted
derivatives
thrombotic
Prior art date
Application number
MX2021007508A
Other languages
English (en)
Inventor
Alexander Hillisch
Dieter Lang
Adrian Tersteegen
Susanne Röhrig
Stefan Heitmeier
Martina Schäfer
Kersten Matthias Gericke
Sonja Anlauf
Katharina Meier
Jan Stampfuss
Pascal Ellerbrock
Thomas Neubauer
Sebastian Essig
Hongping Wang
Zengqiang Zou
Xianghai Meng
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2021007508A publication Critical patent/MX2021007508A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a derivados de oxopiridina sustituidos y a procesos para su preparación, y también a su uso para preparar medicamentos para el tratamiento y/o la profilaxis de enfermedades, en particular trastornos vasculares, preferentemente trastornos trombóticos o tromboembólicos y/o complicaciones trombóticas o tromboembólicas.
MX2021007508A 2018-12-21 2019-12-18 Derivados de oxopiridina sustituidos. MX2021007508A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2018122825 2018-12-21
PCT/EP2019/085983 WO2020127504A1 (en) 2018-12-21 2019-12-18 Substituted oxopyridine derivatives

Publications (1)

Publication Number Publication Date
MX2021007508A true MX2021007508A (es) 2021-08-05

Family

ID=69143542

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021007508A MX2021007508A (es) 2018-12-21 2019-12-18 Derivados de oxopiridina sustituidos.

Country Status (22)

Country Link
EP (1) EP3898633A1 (es)
JP (1) JP2022514303A (es)
KR (1) KR20210106504A (es)
CN (1) CN113474348A (es)
AR (1) AR117435A1 (es)
AU (1) AU2019407909B2 (es)
BR (1) BR112021009435A2 (es)
CA (1) CA3124220A1 (es)
CL (1) CL2021001613A1 (es)
CO (1) CO2021007908A2 (es)
CR (1) CR20210342A (es)
DO (1) DOP2021000128A (es)
EA (1) EA202191764A1 (es)
EC (1) ECSP21043895A (es)
IL (1) IL283990A (es)
JO (1) JOP20210161A1 (es)
MA (1) MA54521A (es)
MX (1) MX2021007508A (es)
PE (1) PE20211790A1 (es)
SG (1) SG11202104384PA (es)
TW (1) TW202039510A (es)
WO (1) WO2020127504A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11542245B2 (en) * 2018-03-15 2023-01-03 Bayer Pharma Aktiengesellschaft Preparative process
CN114105881B (zh) 2020-08-31 2024-01-26 沈阳海诺威医药科技有限公司 血小板聚集抑制剂及其制备方法和用途
WO2022189280A1 (en) 2021-03-09 2022-09-15 Bayer Aktiengesellschaft Solvates of (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5-dioxo-14-(trifluoro-methyl)-32 h-6- aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide
JP2024508971A (ja) 2021-03-09 2024-02-28 バイエル・アクチエンゲゼルシヤフト （４ｓ）－２４－クロロ－４－エチル－７３－フルオロ－３５－メトキシ－３２，５－ジオキソ－１４－（トリフルオロメチル）－３２ｈ－６－アザ－３（４，１）－ピリジナ－１（１）－［１，２，３］トリアゾラ－２（１，２），７（１）－５ ジベンゼナヘプタファン－７４－カルボキサミドの結晶形態
IL305235A (en) 2021-03-09 2023-10-01 Bayer Ag Pharmaceutical dosage forms containing (4S)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5-dioxo-14-(trifluoromethyl)- 32H -6-aza-3(1,4)-pyridine -1 (1)-[3,2,1]triazol-2-(2,1),7(1)-dibenzeneheptapane-74-carboxamide
CN114560754A (zh) * 2022-02-25 2022-05-31 滁州学院 一种烷基醇的制备方法
CN116874469B (zh) * 2023-09-06 2023-11-10 成都施贝康生物医药科技有限公司 一种氧代吡啶类化合物、中间体及其制备方法和用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
DE102006032824A1 (de) * 2006-07-14 2008-01-17 Bayer Healthcare Ag Substituierte Indazole
US8163779B2 (en) 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
US9809545B2 (en) 2013-03-27 2017-11-07 Merck Sharp & Dohme Corp. Factor XIa inhibitors
TWI633089B (zh) * 2013-03-28 2018-08-21 拜耳製藥股份有限公司 經取代的酮基吡啶衍生物
CA2918814C (en) 2013-07-23 2021-10-12 Bayer Pharma Aktiengesellschaft Substituted oxopyridine derivatives and use thereof as factor xia/plasma
CA2928867A1 (en) 2013-10-30 2015-05-07 Bayer Pharma Aktiengesellschaft Substituted oxopyridine derivatives
WO2016046156A1 (de) 2014-09-24 2016-03-31 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate
ES2716417T3 (es) 2014-09-24 2019-06-12 Bayer Pharma AG Derivados de oxopiridina sustituidos con acción antiinflamatoria y antitrombótica
WO2016046164A1 (de) 2014-09-24 2016-03-31 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate
ES2712886T3 (es) 2014-09-24 2019-05-16 Bayer Pharma AG Derivados de piridobenzazepina y piridobenzazocina que inhiben el factor XIa
ES2722425T3 (es) 2014-09-24 2019-08-12 Bayer Pharma AG (2H)-2-Oxopiridinas como inhibidores del factor XIa para el tratamiento de enfermedades trombóticas
EP3197896B1 (de) 2014-09-24 2019-01-30 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate
EP3271332A1 (de) * 2015-03-19 2018-01-24 Bayer Pharma Aktiengesellschaft Oxopyridin-derivate als faktor xia hemmer zur behandlung von thrombose
JO3703B1 (ar) 2015-07-09 2021-01-31 Bayer Pharma AG مشتقات أوكسوبيريدين مستبدلة
WO2017037051A1 (de) 2015-09-04 2017-03-09 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate

Also Published As

Publication number Publication date
AR117435A1 (es) 2021-08-04
AU2019407909A1 (en) 2021-05-27
SG11202104384PA (en) 2021-05-28
WO2020127504A1 (en) 2020-06-25
CL2021001613A1 (es) 2021-12-03
TW202039510A (zh) 2020-11-01
CA3124220A1 (en) 2020-06-25
JOP20210161A1 (ar) 2023-01-30
CO2021007908A2 (es) 2021-07-19
JP2022514303A (ja) 2022-02-10
ECSP21043895A (es) 2021-07-30
CN113474348A (zh) 2021-10-01
EP3898633A1 (en) 2021-10-27
EA202191764A1 (ru) 2021-10-22
AU2019407909B2 (en) 2023-05-25
BR112021009435A2 (pt) 2021-08-17
IL283990A (en) 2021-07-29
CR20210342A (es) 2021-08-09
KR20210106504A (ko) 2021-08-30
DOP2021000128A (es) 2021-09-30
MA54521A (fr) 2022-03-30
PE20211790A1 (es) 2021-09-09

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