EA202190693A1 - Способы анализа масс-спектрометрии композиций модифицированных клеток - Google Patents
Способы анализа масс-спектрометрии композиций модифицированных клетокInfo
- Publication number
- EA202190693A1 EA202190693A1 EA202190693A EA202190693A EA202190693A1 EA 202190693 A1 EA202190693 A1 EA 202190693A1 EA 202190693 A EA202190693 A EA 202190693A EA 202190693 A EA202190693 A EA 202190693A EA 202190693 A1 EA202190693 A1 EA 202190693A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- mass spectrometry
- methods
- modified cell
- cell composition
- profile
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- 238000004949 mass spectrometry Methods 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 4
- 238000004458 analytical method Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 7
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
Настоящее изобретение относится к способам получения профиля масс-спектрометрии (MS) образца из композиции клеток, такой как композиция модифицированных клеток. В некоторых вариантах осуществления профиль масс-спектрометрии включает данные, основанные на одном или более анализах или способах масс-спектрометрии. Настоящее изобретение относится также к способам на основании профилей масс-спектрометрии одного или более образцов таких композиций клеток: идентификации профиля масс-спектрометрии (MS) композиции генетически модифицированных клеток, содержащий иммуноциты, содержащие рекомбинантный рецептор, посредством сравнения с эталонным профилем масс-спектрометрии; характеризации способа получения композиции генетически модифицированных клеток; оценки белков поверхности клеток из композиции модифицированных клеток и оценки способа получения композиции генетически модифицированных клеток.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862729985P | 2018-09-11 | 2018-09-11 | |
PCT/US2019/050681 WO2020056047A1 (en) | 2018-09-11 | 2019-09-11 | Methods for mass spectrometry analysis of engineered cell compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202190693A1 true EA202190693A1 (ru) | 2021-07-27 |
Family
ID=68136527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202190693A EA202190693A1 (ru) | 2018-09-11 | 2019-09-11 | Способы анализа масс-спектрометрии композиций модифицированных клеток |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220050114A1 (ru) |
EP (1) | EP3850366A1 (ru) |
JP (1) | JP7504891B2 (ru) |
KR (1) | KR20210081341A (ru) |
CN (1) | CN113167796A (ru) |
AU (1) | AU2019339464A1 (ru) |
BR (1) | BR112021004261A2 (ru) |
CA (1) | CA3111789A1 (ru) |
EA (1) | EA202190693A1 (ru) |
IL (1) | IL281325A (ru) |
MA (1) | MA53612A (ru) |
MX (1) | MX2021002574A (ru) |
SG (1) | SG11202102108QA (ru) |
WO (1) | WO2020056047A1 (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CA3059584A1 (en) | 2017-04-14 | 2018-10-18 | Juno Therapeutics, Inc. | Methods for assessing cell surface glycosylation |
EP4277917A4 (en) * | 2021-01-14 | 2024-06-19 | Biocatalyst LLC | COMPOSITIONS AND PROCESSES FOR PRODUCING PEPTIDES |
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RU2713333C2 (ru) | 2013-07-15 | 2020-02-04 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Способы получения т-клеток против антигена папилломавируса человека |
US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
EP3647412A1 (en) | 2014-04-23 | 2020-05-06 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
CN113604491A (zh) | 2014-05-02 | 2021-11-05 | 宾夕法尼亚大学董事会 | 嵌合自身抗体受体t细胞的组合物和方法 |
EP3149031B1 (en) | 2014-05-29 | 2019-12-18 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-human papillomavirus 16 e7 t cell receptors |
EP2990416B1 (en) | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
PT3757206T (pt) | 2014-11-05 | 2024-05-21 | Juno Therapeutics Inc | Métodos de transdução e processamento de células |
WO2018027197A1 (en) | 2016-08-04 | 2018-02-08 | Memorial Sloan-Kettering Cancer Center | Cancer antigen targets and uses thereof |
JP7228522B2 (ja) | 2017-02-27 | 2023-02-24 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法における投薬に関する組成物、製造物品、および方法 |
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- 2019-09-11 KR KR1020217010583A patent/KR20210081341A/ko not_active Application Discontinuation
- 2019-09-11 CA CA3111789A patent/CA3111789A1/en active Pending
- 2019-09-11 MX MX2021002574A patent/MX2021002574A/es unknown
- 2019-09-11 EA EA202190693A patent/EA202190693A1/ru unknown
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- 2019-09-11 BR BR112021004261-0A patent/BR112021004261A2/pt unknown
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BR112021004261A2 (pt) | 2021-05-25 |
AU2019339464A1 (en) | 2021-03-25 |
MX2021002574A (es) | 2021-06-08 |
US20220050114A1 (en) | 2022-02-17 |
EP3850366A1 (en) | 2021-07-21 |
JP7504891B2 (ja) | 2024-06-24 |
KR20210081341A (ko) | 2021-07-01 |
WO2020056047A1 (en) | 2020-03-19 |
SG11202102108QA (en) | 2021-04-29 |
CA3111789A1 (en) | 2020-03-19 |
MA53612A (fr) | 2021-09-15 |
IL281325A (en) | 2021-04-29 |
JP2022500674A (ja) | 2022-01-04 |
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