EA202190654A1 - Гетероциклическое соединение - Google Patents

Гетероциклическое соединение

Info

Publication number
EA202190654A1
EA202190654A1 EA202190654A EA202190654A EA202190654A1 EA 202190654 A1 EA202190654 A1 EA 202190654A1 EA 202190654 A EA202190654 A EA 202190654A EA 202190654 A EA202190654 A EA 202190654A EA 202190654 A1 EA202190654 A1 EA 202190654A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ring
compound
heterocyclic
connection
heterocyclic connection
Prior art date
Application number
EA202190654A
Other languages
English (en)
Inventor
Казухиро Охдати
Юсуке Фудзимори
Наоя Макита
Норитака Косеки
Хидеки Хаяси
Юки Сакамото
Куруми Минето
Риосуке Тага
Original Assignee
Оцука Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оцука Фармасьютикал Ко., Лтд. filed Critical Оцука Фармасьютикал Ко., Лтд.
Publication of EA202190654A1 publication Critical patent/EA202190654A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Представлено новое гетероциклическое соединение, обладающее антагонистической активностью по отношению к рецептору ароматических углеводородов и применимое для промотирования выработки тромбоцитов, соединение представлено общей формулой [I]где кольцо A, кольцо B, R1, R2, R3, R4, n и X являются такими, как определено выше, или его соль.
EA202190654A 2018-09-07 2019-09-06 Гетероциклическое соединение EA202190654A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018167488 2018-09-07
PCT/JP2019/035233 WO2020050409A1 (en) 2018-09-07 2019-09-06 Heterocyclic compound

Publications (1)

Publication Number Publication Date
EA202190654A1 true EA202190654A1 (ru) 2021-05-27

Family

ID=68063002

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190654A EA202190654A1 (ru) 2018-09-07 2019-09-06 Гетероциклическое соединение

Country Status (12)

Country Link
US (2) US11932657B2 (ru)
EP (1) EP3847176A1 (ru)
JP (1) JP7448527B2 (ru)
KR (1) KR20210056373A (ru)
CN (1) CN112654627A (ru)
AU (2) AU2019335968B2 (ru)
CA (1) CA3109610A1 (ru)
EA (1) EA202190654A1 (ru)
IL (1) IL280821A (ru)
SG (1) SG11202101963XA (ru)
TW (1) TW202035423A (ru)
WO (1) WO2020050409A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202035423A (zh) 2018-09-07 2020-10-01 日商大塚製藥股份有限公司 雜環化合物
CA3155466A1 (en) 2019-12-09 2021-06-17 Otsuka Pharmaceutical Co., Ltd. Acrylamide compounds
KR20220153595A (ko) 2020-02-26 2022-11-18 재규어 테라퓨틱스 피티이 리미티드 AhR 신호전달의 조절에 유용한 피리도피리미딘 유도체
CN114181212B (zh) * 2020-09-15 2023-06-06 山东轩竹医药科技有限公司 哒嗪酮类AhR抑制剂
CN115215720B (zh) * 2021-04-19 2023-08-22 中国科学院化学研究所 含薁单元的石墨烯纳米片段分子—薁并玉红省及其合成方法与应用
WO2022228399A1 (zh) * 2021-04-27 2022-11-03 山东轩竹医药科技有限公司 三并环类usp1抑制剂及其用途
CN118076613A (zh) * 2021-09-02 2024-05-24 捷豹治疗有限公司 可用于调节AhR信号传导的化合物
WO2023033742A1 (en) * 2021-09-02 2023-03-09 Jaguahr Therapeutics Pte Ltd Compounds useful in modulation of ahr signalling
WO2023033741A1 (en) * 2021-09-02 2023-03-09 Jaguahr Therapeutics Pte Ltd Compounds useful in modulation of ahr signalling
WO2024076300A1 (en) 2022-10-03 2024-04-11 Jaguahr Therapeutics Pte Ltd Compounds useful in modulation of ahr signalling

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20100362A1 (es) 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
TW201500358A (zh) 2010-12-16 2015-01-01 Hoffmann La Roche 三環ｐｉ３ｋ抑制劑化合物及其使用方法
WO2014138485A1 (en) 2013-03-08 2014-09-12 Irm Llc Ex vivo production of platelets from hematopoietic stem cells and the product thereof
ES2839220T3 (es) 2015-06-16 2021-07-05 Univ Kyoto Procedimiento de fabricación de plaquetas de alto rendimiento
JP7232244B2 (ja) 2017-04-21 2023-03-08 イケナ オンコロジー， インコーポレイテッド インドールａｈｒ阻害剤およびその使用
WO2019167973A1 (en) 2018-03-01 2019-09-06 Kyoto University Cell cycle progression inhibitor
TW202035423A (zh) 2018-09-07 2020-10-01 日商大塚製藥股份有限公司 雜環化合物
CA3155466A1 (en) 2019-12-09 2021-06-17 Otsuka Pharmaceutical Co., Ltd. Acrylamide compounds
JP2022188761A (ja) 2021-06-09 2022-12-21 大塚製薬株式会社 窒素原子含有複素環化合物を用いる血小板産生方法

Also Published As

Publication number Publication date
IL280821A (en) 2021-04-29
US20210340157A1 (en) 2021-11-04
EP3847176A1 (en) 2021-07-14
AU2019335968B2 (en) 2024-03-07
CN112654627A (zh) 2021-04-13
US11932657B2 (en) 2024-03-19
SG11202101963XA (en) 2021-03-30
JP2021536482A (ja) 2021-12-27
CA3109610A1 (en) 2020-03-12
AU2024203760A1 (en) 2024-06-20
JP7448527B2 (ja) 2024-03-12
AU2019335968A1 (en) 2021-05-06
TW202035423A (zh) 2020-10-01
WO2020050409A1 (en) 2020-03-12
KR20210056373A (ko) 2021-05-18
US20240208999A1 (en) 2024-06-27

Similar Documents

Publication Publication Date Title
EA202190654A1 (ru) Гетероциклическое соединение
EA201991544A1 (ru) ПРОИЗВОДНЫЕ ПИРРОЛО[1,2-b]ПИРИДАЗИНА
EA201891742A1 (ru) Замещенное пиперидиновое соединение и его применение
UY37623A (es) Derivados de oxadiazol tiofeno fungicidas
EA201700230A1 (ru) Определенные аминопиридины, композиции на их основе и способы их применения
EA201690019A1 (ru) Производное аминотриазина и содержащая его фармацевтическая композиция
BRPI0511933A (pt) derivados de quinazolinona úteis como antagonistas de vanilóide
EA201101673A1 (ru) Замещенные хиназолины в качестве фунгицидов
EA201390877A1 (ru) Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение
EA201070994A1 (ru) Конденсированное гетероциклическое производное и его применение
PH12018500582A1 (en) Crosslinked nucleic acid guna, method for producing same, and intermediate compound
TR201900662T4 (tr) Cb2 reseptör antagonistleri olarak triazolo[4,5-d]pirimidin türevleri.
EA201070876A1 (ru) Трициклические соединения, обладающие антагонистической активностью по отношению к кортикотропин-высвобождающему фактору, и содержащие их фармацевтические композиции
CY1125004T1 (el) Ετεροαρυλο υποκατεστημενες βητα-υδροξυαιθυλαμινες για χρηση στη θεραπεια της υπεργλυκαιμιας
TR201900393T4 (tr) 1,2-Dihidro-3H-Pirolo[1,2-C]İmidazol-3-On Türevleri Ve Bunların Antibakteriyel Ajanlar Olarak Kullanımı
BR112012017277A2 (pt) Compostos e métodos
MA32956B1 (fr) Derives de 5-amino-2-(1-hydroxyethyl)-tetrahydropyrane
PH12018500301A1 (en) Substituted 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one antibacterials
EA202190880A1 (ru) Кристаллическая форма морфолинохиназолинового соединения, способ ее получения и ее применение
AR097253A1 (es) Derivado de pirazolilpirazol sustituido y el uso del mismo como herbicida
MY160882A (en) Biocidal composition and method
EA202090653A1 (ru) Циклоолефиновые замещённые гетероароматические соединения и их применение
CY1113484T1 (el) Ενωση 3-φαινυλπυραζολο[5,1-b]θειαζολιου
ME01144B (me) 3-aminociklopentankarboksamidi kao modulatori hemokin receptora
CO6481003A2 (es) Compuesto de benzazepina