EA202190126A1 - Композиция конденсированных трициклических производных гамма-аминокислоты и её приготовление - Google Patents

Композиция конденсированных трициклических производных гамма-аминокислоты и её приготовление

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Publication number
EA202190126A1
EA202190126A1 EA202190126A EA202190126A EA202190126A1 EA 202190126 A1 EA202190126 A1 EA 202190126A1 EA 202190126 A EA202190126 A EA 202190126A EA 202190126 A EA202190126 A EA 202190126A EA 202190126 A1 EA202190126 A1 EA 202190126A1
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EA
Eurasian Patent Office
Prior art keywords
amino acid
preparation
composition
acid derivatives
condensed tricyclic
Prior art date
Application number
EA202190126A
Other languages
English (en)
Inventor
Сюаньмяо Чжан
Фэн Пэн
Хуа Мао
Цзюаньцзюань Дэн
Панкэ Янь
Original Assignee
Сычуань Хайско Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Сычуань Хайско Фармасьютикал Ко., Лтд. filed Critical Сычуань Хайско Фармасьютикал Ко., Лтд.
Publication of EA202190126A1 publication Critical patent/EA202190126A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Согласно настоящему изобретению предложена фармацевтическая композиция конденсированных трициклических производных гамма-аминокислоты и ее применение. Фармацевтическая композиция содержит (1) соединение, имеющее структуру, представленную формулой (I), или его фармацевтически приемлемую соль в качестве активного вещества в количестве от 1 до 45 мас.%; (2) возможно один или более чем один наполнитель в количестве от 50 до 95 мас.%; (3) возможно одно или более чем одно смазывающее вещество в количестве от 0,1 до 5,5 мас.%; и сумма массовых процентов всех компонентов составляет 100%, где фармацевтически приемлемая соль соединения формулы (I) имеет следующую структуру:
EA202190126A 2018-07-12 2019-07-12 Композиция конденсированных трициклических производных гамма-аминокислоты и её приготовление EA202190126A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810756863 2018-07-12
PCT/CN2019/095856 WO2020011257A1 (zh) 2018-07-12 2019-07-12 一种稠合三环γ-氨基酸衍生物的组合物及其制备

Publications (1)

Publication Number Publication Date
EA202190126A1 true EA202190126A1 (ru) 2021-06-30

Family

ID=69142171

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190126A EA202190126A1 (ru) 2018-07-12 2019-07-12 Композиция конденсированных трициклических производных гамма-аминокислоты и её приготовление

Country Status (12)

Country Link
US (1) US20210186909A1 (ru)
EP (1) EP3822252A4 (ru)
JP (1) JP7222063B2 (ru)
KR (1) KR102515847B1 (ru)
CN (1) CN112384494A (ru)
AU (1) AU2019302611B2 (ru)
CA (1) CA3106382C (ru)
EA (1) EA202190126A1 (ru)
MX (1) MX2021000403A (ru)
TW (1) TWI808217B (ru)
WO (1) WO2020011257A1 (ru)
ZA (1) ZA202100181B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202214223A (zh) * 2020-07-20 2022-04-16 大陸商四川海思科製藥有限公司 稠合三環γ-胺基酸衍生物的緩釋藥物製劑及其製備方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0223072D0 (en) * 2002-10-04 2002-11-13 Pfizer Ltd Cyclic nitromethyl acetic acid derivatives
CN1827095A (zh) * 2006-04-14 2006-09-06 北京润德康医药技术有限公司 一种以普瑞巴林为活性成分的药用组合物及其制备方法、用途
WO2008057267A2 (en) * 2006-10-27 2008-05-15 Fmc Corporation Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations
MY153910A (en) * 2007-09-28 2015-04-15 Daiichi Sankyo Co Ltd BICYCLIC y-AMINO ACID DERIVATIVE
WO2010079668A1 (ja) * 2009-01-08 2010-07-15 第一三共株式会社 オレフィン化合物
CN107848952B (zh) * 2015-12-31 2021-04-09 四川海思科制药有限公司 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用
KR102539234B1 (ko) * 2016-04-07 2023-06-02 에스케이케미칼 주식회사 은행잎 추출물을 포함하는 경구용 서방 제제
US10654794B2 (en) * 2016-09-14 2020-05-19 Sichuan Haiso Pharmaceutical Co., Ltd. Fused tricyclic Γ-amino acid derivative, preparation method therefor, and medical use thereof

Also Published As

Publication number Publication date
WO2020011257A1 (zh) 2020-01-16
KR102515847B1 (ko) 2023-03-29
CA3106382A1 (en) 2020-01-16
EP3822252A1 (en) 2021-05-19
MX2021000403A (es) 2021-03-25
EP3822252A4 (en) 2021-11-17
JP7222063B2 (ja) 2023-02-14
TW202012362A (zh) 2020-04-01
AU2019302611B2 (en) 2022-02-17
CN112384494A (zh) 2021-02-19
TWI808217B (zh) 2023-07-11
ZA202100181B (en) 2022-06-29
CA3106382C (en) 2023-11-07
KR20210028680A (ko) 2021-03-12
JP2021525789A (ja) 2021-09-27
US20210186909A1 (en) 2021-06-24
BR112021000398A2 (pt) 2021-04-06
AU2019302611A1 (en) 2021-02-25

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