EA202091626A1 - Инъецируемые композиции тритерпеноидных противогрибковых соединений, инкапсулированных в липосомах - Google Patents

Инъецируемые композиции тритерпеноидных противогрибковых соединений, инкапсулированных в липосомах

Info

Publication number
EA202091626A1
EA202091626A1 EA202091626A EA202091626A EA202091626A1 EA 202091626 A1 EA202091626 A1 EA 202091626A1 EA 202091626 A EA202091626 A EA 202091626A EA 202091626 A EA202091626 A EA 202091626A EA 202091626 A1 EA202091626 A1 EA 202091626A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antifungal compounds
incapped
liposomes
fungal infections
triterpenoid
Prior art date
Application number
EA202091626A
Other languages
English (en)
Russian (ru)
Inventor
Раджешвар Мозерам
Original Assignee
Сайнексис, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сайнексис, Инк. filed Critical Сайнексис, Инк.
Publication of EA202091626A1 publication Critical patent/EA202091626A1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277Preparation processes; Proliposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
EA202091626A 2018-01-02 2018-12-21 Инъецируемые композиции тритерпеноидных противогрибковых соединений, инкапсулированных в липосомах EA202091626A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862612893P 2018-01-02 2018-01-02
PCT/US2018/067216 WO2019135954A1 (en) 2018-01-02 2018-12-21 Injectable compositions of triterpenoid antifungals encapsulated in liposomes

Publications (1)

Publication Number Publication Date
EA202091626A1 true EA202091626A1 (ru) 2020-09-22

Family

ID=65024141

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202091626A EA202091626A1 (ru) 2018-01-02 2018-12-21 Инъецируемые композиции тритерпеноидных противогрибковых соединений, инкапсулированных в липосомах

Country Status (27)

Country Link
US (3) US20200338002A1 (https=)
EP (2) EP4137123A1 (https=)
JP (3) JP7378401B2 (https=)
KR (1) KR102694692B1 (https=)
CN (2) CN115998684A (https=)
AU (1) AU2018399599B2 (https=)
CA (1) CA3087176A1 (https=)
DK (1) DK3735226T3 (https=)
EA (1) EA202091626A1 (https=)
ES (1) ES2927051T3 (https=)
HR (1) HRP20221295T1 (https=)
HU (1) HUE060400T2 (https=)
IL (2) IL275758B2 (https=)
LT (1) LT3735226T (https=)
MA (1) MA51514A (https=)
MD (1) MD3735226T2 (https=)
MX (1) MX2020006992A (https=)
PL (1) PL3735226T3 (https=)
PT (1) PT3735226T (https=)
RS (1) RS63687B1 (https=)
SA (1) SA520412362B1 (https=)
SG (1) SG11202006313WA (https=)
SI (1) SI3735226T1 (https=)
SM (1) SMT202200427T1 (https=)
TW (2) TWI857944B (https=)
UA (1) UA126096C2 (https=)
WO (1) WO2019135954A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3087176A1 (en) * 2018-01-02 2019-07-11 Scynexis, Inc. Injectable compositions of triterpenoid antifungals encapsulated in liposomes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
US7718189B2 (en) * 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
NZ548195A (en) * 2004-01-14 2011-01-28 Gilead Sciences Inc Lipid-based dispersions useful for drug delivery
JP5245057B2 (ja) 2006-04-03 2013-07-24 メルク・シャープ・アンド・ドーム・コーポレーション 抗真菌剤
CN101861150B (zh) * 2007-09-28 2014-07-16 默克夏普和道赫莫公司 抗真菌制剂
JP2011518844A (ja) * 2008-04-25 2011-06-30 ナノバイオ コーポレーション 真菌、酵母および糸状菌感染症を治療するためのナノエマルション
AU2009275230A1 (en) * 2008-07-23 2010-01-28 Targeted Delivery Technologies Limited Methods of administering topical antifungal formulations for the treatment of fungal infections
WO2010019204A1 (en) * 2008-08-12 2010-02-18 Merck Sharp & Dohme Corp. Antifungal agents
ES2593027T3 (es) * 2009-03-30 2016-12-05 Eisai R&D Management Co., Ltd. Composición liposomal
HRP20220544T1 (hr) * 2015-01-19 2022-08-05 Scynexis, Inc. Nove soli i polimorfi scy-078
CA3087176A1 (en) * 2018-01-02 2019-07-11 Scynexis, Inc. Injectable compositions of triterpenoid antifungals encapsulated in liposomes

Also Published As

Publication number Publication date
US20230277455A1 (en) 2023-09-07
LT3735226T (lt) 2022-11-10
EP3735226B1 (en) 2022-08-10
KR20200105875A (ko) 2020-09-09
JP7378401B2 (ja) 2023-11-13
SMT202200427T1 (it) 2022-11-18
JP2024012452A (ja) 2024-01-30
DK3735226T3 (da) 2022-10-24
JP2025106349A (ja) 2025-07-15
HUE060400T2 (hu) 2023-02-28
SA520412362B1 (ar) 2022-12-15
US20250082574A1 (en) 2025-03-13
CN115998684A (zh) 2023-04-25
HRP20221295T1 (hr) 2022-12-23
SI3735226T1 (sl) 2022-11-30
RS63687B1 (sr) 2022-11-30
BR112020013448A2 (pt) 2020-12-01
IL275758B2 (en) 2025-07-01
IL318793A (en) 2025-04-01
WO2019135954A1 (en) 2019-07-11
MD3735226T2 (ro) 2023-03-31
PT3735226T (pt) 2022-09-20
TW201929853A (zh) 2019-08-01
TW202434242A (zh) 2024-09-01
KR102694692B1 (ko) 2024-08-14
EP4137123A1 (en) 2023-02-22
MX2020006992A (es) 2020-09-09
UA126096C2 (uk) 2022-08-10
CA3087176A1 (en) 2019-07-11
NZ765771A (en) 2024-09-27
JP2021508728A (ja) 2021-03-11
MA51514A (fr) 2021-04-07
IL275758A (en) 2020-08-31
IL275758B1 (en) 2025-03-01
AU2018399599A1 (en) 2020-07-16
ES2927051T3 (es) 2022-11-02
TWI857944B (zh) 2024-10-11
SG11202006313WA (en) 2020-07-29
CN111655237B (zh) 2023-02-03
EP3735226A1 (en) 2020-11-11
PL3735226T3 (pl) 2022-12-19
CN111655237A (zh) 2020-09-11
TWI862280B (zh) 2024-11-11
US20200338002A1 (en) 2020-10-29
AU2018399599B2 (en) 2022-09-01

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