CN115998684A - 包覆于脂质体中的三萜类抗真菌剂的可注射组合物 - Google Patents

包覆于脂质体中的三萜类抗真菌剂的可注射组合物 Download PDF

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Publication number
CN115998684A
CN115998684A CN202310046755.4A CN202310046755A CN115998684A CN 115998684 A CN115998684 A CN 115998684A CN 202310046755 A CN202310046755 A CN 202310046755A CN 115998684 A CN115998684 A CN 115998684A
Authority
CN
China
Prior art keywords
injectable composition
phosphatidylcholine
scy
coated
aqueous phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202310046755.4A
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English (en)
Chinese (zh)
Inventor
R·马瑟拉姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scynexis Inc
Original Assignee
Scynexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scynexis Inc filed Critical Scynexis Inc
Publication of CN115998684A publication Critical patent/CN115998684A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
CN202310046755.4A 2018-01-02 2018-12-21 包覆于脂质体中的三萜类抗真菌剂的可注射组合物 Pending CN115998684A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862612893P 2018-01-02 2018-01-02
US62/612,893 2018-01-02
CN201880087851.0A CN111655237B (zh) 2018-01-02 2018-12-21 包覆于脂质体中的三萜类抗真菌剂的可注射组合物
PCT/US2018/067216 WO2019135954A1 (en) 2018-01-02 2018-12-21 Injectable compositions of triterpenoid antifungals encapsulated in liposomes

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880087851.0A Division CN111655237B (zh) 2018-01-02 2018-12-21 包覆于脂质体中的三萜类抗真菌剂的可注射组合物

Publications (1)

Publication Number Publication Date
CN115998684A true CN115998684A (zh) 2023-04-25

Family

ID=65024141

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202310046755.4A Pending CN115998684A (zh) 2018-01-02 2018-12-21 包覆于脂质体中的三萜类抗真菌剂的可注射组合物
CN201880087851.0A Active CN111655237B (zh) 2018-01-02 2018-12-21 包覆于脂质体中的三萜类抗真菌剂的可注射组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201880087851.0A Active CN111655237B (zh) 2018-01-02 2018-12-21 包覆于脂质体中的三萜类抗真菌剂的可注射组合物

Country Status (27)

Country Link
US (3) US20200338002A1 (https=)
EP (2) EP4137123A1 (https=)
JP (3) JP7378401B2 (https=)
KR (1) KR102694692B1 (https=)
CN (2) CN115998684A (https=)
AU (1) AU2018399599B2 (https=)
CA (1) CA3087176A1 (https=)
DK (1) DK3735226T3 (https=)
EA (1) EA202091626A1 (https=)
ES (1) ES2927051T3 (https=)
HR (1) HRP20221295T1 (https=)
HU (1) HUE060400T2 (https=)
IL (2) IL275758B2 (https=)
LT (1) LT3735226T (https=)
MA (1) MA51514A (https=)
MD (1) MD3735226T2 (https=)
MX (1) MX2020006992A (https=)
PL (1) PL3735226T3 (https=)
PT (1) PT3735226T (https=)
RS (1) RS63687B1 (https=)
SA (1) SA520412362B1 (https=)
SG (1) SG11202006313WA (https=)
SI (1) SI3735226T1 (https=)
SM (1) SMT202200427T1 (https=)
TW (2) TWI857944B (https=)
UA (1) UA126096C2 (https=)
WO (1) WO2019135954A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3087176A1 (en) * 2018-01-02 2019-07-11 Scynexis, Inc. Injectable compositions of triterpenoid antifungals encapsulated in liposomes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102065851A (zh) * 2008-04-25 2011-05-18 纳米生物公司 治疗真菌、酵母和霉菌感染的纳米乳剂
CN102159202A (zh) * 2008-07-23 2011-08-17 靶向递送技术有限公司 施用局部抗真菌制剂治疗真菌感染的方法
US20160207956A1 (en) * 2015-01-19 2016-07-21 Scynexis, Inc. Novel salts and polymorphs of scy-078

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
US7718189B2 (en) * 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
NZ548195A (en) * 2004-01-14 2011-01-28 Gilead Sciences Inc Lipid-based dispersions useful for drug delivery
JP5245057B2 (ja) 2006-04-03 2013-07-24 メルク・シャープ・アンド・ドーム・コーポレーション 抗真菌剤
CN101861150B (zh) * 2007-09-28 2014-07-16 默克夏普和道赫莫公司 抗真菌制剂
WO2010019204A1 (en) * 2008-08-12 2010-02-18 Merck Sharp & Dohme Corp. Antifungal agents
ES2593027T3 (es) * 2009-03-30 2016-12-05 Eisai R&D Management Co., Ltd. Composición liposomal
CA3087176A1 (en) * 2018-01-02 2019-07-11 Scynexis, Inc. Injectable compositions of triterpenoid antifungals encapsulated in liposomes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102065851A (zh) * 2008-04-25 2011-05-18 纳米生物公司 治疗真菌、酵母和霉菌感染的纳米乳剂
CN102159202A (zh) * 2008-07-23 2011-08-17 靶向递送技术有限公司 施用局部抗真菌制剂治疗真菌感染的方法
US20160207956A1 (en) * 2015-01-19 2016-07-21 Scynexis, Inc. Novel salts and polymorphs of scy-078

Also Published As

Publication number Publication date
US20230277455A1 (en) 2023-09-07
LT3735226T (lt) 2022-11-10
EP3735226B1 (en) 2022-08-10
KR20200105875A (ko) 2020-09-09
JP7378401B2 (ja) 2023-11-13
SMT202200427T1 (it) 2022-11-18
JP2024012452A (ja) 2024-01-30
DK3735226T3 (da) 2022-10-24
JP2025106349A (ja) 2025-07-15
HUE060400T2 (hu) 2023-02-28
SA520412362B1 (ar) 2022-12-15
US20250082574A1 (en) 2025-03-13
HRP20221295T1 (hr) 2022-12-23
SI3735226T1 (sl) 2022-11-30
RS63687B1 (sr) 2022-11-30
BR112020013448A2 (pt) 2020-12-01
EA202091626A1 (ru) 2020-09-22
IL275758B2 (en) 2025-07-01
IL318793A (en) 2025-04-01
WO2019135954A1 (en) 2019-07-11
MD3735226T2 (ro) 2023-03-31
PT3735226T (pt) 2022-09-20
TW201929853A (zh) 2019-08-01
TW202434242A (zh) 2024-09-01
KR102694692B1 (ko) 2024-08-14
EP4137123A1 (en) 2023-02-22
MX2020006992A (es) 2020-09-09
UA126096C2 (uk) 2022-08-10
CA3087176A1 (en) 2019-07-11
NZ765771A (en) 2024-09-27
JP2021508728A (ja) 2021-03-11
MA51514A (fr) 2021-04-07
IL275758A (en) 2020-08-31
IL275758B1 (en) 2025-03-01
AU2018399599A1 (en) 2020-07-16
ES2927051T3 (es) 2022-11-02
TWI857944B (zh) 2024-10-11
SG11202006313WA (en) 2020-07-29
CN111655237B (zh) 2023-02-03
EP3735226A1 (en) 2020-11-11
PL3735226T3 (pl) 2022-12-19
CN111655237A (zh) 2020-09-11
TWI862280B (zh) 2024-11-11
US20200338002A1 (en) 2020-10-29
AU2018399599B2 (en) 2022-09-01

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Application publication date: 20230425