EA202090404A1 - Универсальный способ презентирования циклического пептида на белковой структуре - Google Patents

Универсальный способ презентирования циклического пептида на белковой структуре

Info

Publication number
EA202090404A1
EA202090404A1 EA202090404A EA202090404A EA202090404A1 EA 202090404 A1 EA202090404 A1 EA 202090404A1 EA 202090404 A EA202090404 A EA 202090404A EA 202090404 A EA202090404 A EA 202090404A EA 202090404 A1 EA202090404 A1 EA 202090404A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyclic peptide
presenting
protein structure
universal method
cyclic
Prior art date
Application number
EA202090404A
Other languages
English (en)
Inventor
Хироаки Суга
Дзунити Такаги
Original Assignee
Дзе Юниверсити Оф Токио
Осака Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Юниверсити Оф Токио, Осака Юниверсити filed Critical Дзе Юниверсити Оф Токио
Publication of EA202090404A1 publication Critical patent/EA202090404A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link

Abstract

Настоящее изобретение относится к способу презентирования циклического пептида на белке, содержащем петлевую структуру. Циклический пептид содержит химически перекрестно сшитую структуру для получения внутримолекулярной циклической структуры. Способ включает замену химически перекрестно сшитой структуры циклического пептида двумя аминокислотными остатками, образующими петлевую структуру, и, таким образом, слияние циклического пептида с белком, содержащим петлевую структуру.
EA202090404A 2017-07-31 2018-07-31 Универсальный способ презентирования циклического пептида на белковой структуре EA202090404A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017148622 2017-07-31
PCT/JP2018/028705 WO2019026920A1 (ja) 2017-07-31 2018-07-31 環状ペプチドをタンパク質構造に提示させる超汎用法

Publications (1)

Publication Number Publication Date
EA202090404A1 true EA202090404A1 (ru) 2020-05-21

Family

ID=65232781

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090404A EA202090404A1 (ru) 2017-07-31 2018-07-31 Универсальный способ презентирования циклического пептида на белковой структуре

Country Status (11)

Country Link
US (1) US20200377588A1 (ru)
EP (1) EP3666897A4 (ru)
JP (1) JP6598344B2 (ru)
KR (1) KR102357604B1 (ru)
CN (1) CN110997921A (ru)
AU (2) AU2018312075A1 (ru)
CA (1) CA3071799C (ru)
EA (1) EA202090404A1 (ru)
IL (1) IL272305A (ru)
SG (1) SG11202000801QA (ru)
WO (1) WO2019026920A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210221849A1 (en) * 2018-05-10 2021-07-22 Mirabiologics Inc. Artificial Protein Containing Antigen-Binding Region of Antibody and Being Fused With Physiologically Active Peptide
WO2020027224A1 (ja) * 2018-07-31 2020-02-06 国立大学法人東京大学 新たな結合特異性を抗体に付与する超汎用法
US20230312651A1 (en) * 2020-07-10 2023-10-05 The University Of Tokyo Cyclic Peptide, Peptide Complex, and Drug Composition Containing Said Cyclic Peptide and/or Said Peptide Complex
WO2024048683A1 (ja) * 2022-08-30 2024-03-07 ミラバイオロジクス株式会社 人工タンパク質及び医薬組成物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180343B1 (en) * 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
WO2000073478A2 (en) * 1999-06-01 2000-12-07 University Of Washington Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration
US20020048571A1 (en) 1999-07-19 2002-04-25 Jeno Gyuris Chimeric polypeptides of serum albumin and uses related thereto
JP4809767B2 (ja) * 2003-08-18 2011-11-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 発現ベクター、ポリペプチドディスプレイライブラリ、並びにそれらの作製及び使用方法
EP1797127B1 (en) 2004-09-24 2017-06-14 Amgen Inc. Modified fc molecules
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
AT503889B1 (de) 2006-07-05 2011-12-15 Star Biotechnologische Forschungs Und Entwicklungsges M B H F Multivalente immunglobuline
AT503902B1 (de) 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw Verfahren zur manipulation von immunglobulinen
EP3012265B1 (en) 2007-03-26 2017-06-28 The University of Tokyo Process for synthesizing cyclic peptide compound
EP2267003A1 (en) * 2009-06-24 2010-12-29 Applied NanoSystems B.V. Biologically produced cyclic affinity tags
US20120208720A1 (en) 2009-10-22 2012-08-16 Kenji Kashiwagi Rapid display method in translational synthesis of peptide
EP3248987A1 (en) * 2010-07-30 2017-11-29 Novartis AG Fibronectin cradle molecules and libraries thereof
JP6004399B2 (ja) 2010-12-03 2016-10-05 国立大学法人 東京大学 安定化された二次構造を有するペプチド、及びペプチドライブラリー、それらの製造方法
JP6754997B2 (ja) 2013-08-26 2020-09-16 国立大学法人 東京大学 大環状ペプチド、その製造方法、及び大環状ペプチドライブラリを用いるスクリーニング方法
US20200024581A1 (en) * 2017-12-13 2020-01-23 Aukera, Inc. Methods and compositions for vault nanoparticle immobilization of therapeutic molecules and for vault targeting

Also Published As

Publication number Publication date
US20200377588A1 (en) 2020-12-03
KR102357604B1 (ko) 2022-02-08
EP3666897A4 (en) 2020-11-04
JPWO2019026920A1 (ja) 2019-11-07
AU2021203496B2 (en) 2024-02-01
EP3666897A1 (en) 2020-06-17
SG11202000801QA (en) 2020-02-27
AU2018312075A1 (en) 2020-02-20
CA3071799C (en) 2022-12-13
CA3071799A1 (en) 2019-02-07
CN110997921A (zh) 2020-04-10
AU2021203496A1 (en) 2021-07-01
WO2019026920A1 (ja) 2019-02-07
KR20200032184A (ko) 2020-03-25
IL272305A (en) 2020-03-31
NZ761205A (en) 2021-08-27
JP6598344B2 (ja) 2019-10-30

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