EA201992185A1 - Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения - Google Patents

Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения

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EA201992185A1
EA201992185A1 EA201992185A EA201992185A EA201992185A1 EA 201992185 A1 EA201992185 A1 EA 201992185A1 EA 201992185 A EA201992185 A EA 201992185A EA 201992185 A EA201992185 A EA 201992185A EA 201992185 A1 EA201992185 A1 EA 201992185A1
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Eurasian Patent Office
Prior art keywords
bone
matrix
biological matrix
collagen
hydroxyapatite
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EA201992185A
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English (en)
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Алексей Владимирович ВЕРЕМЕЕВ
Антон Геннадьевич Кутихин
Владимир Георгиевич НЕСТЕРЕНКО
Роман Николаевич БОЛГАРИН
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Ооо "Матрифлекс"
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Publication of EA201992185A1 publication Critical patent/EA201992185A1/ru

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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
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Abstract

Настоящее изобретение относится к медицинской биотехнологии, медицине, травматологии, ортопедии, стоматологии и ортодонтии. Предложенный способ получения биологического матрикса, предназначенного для замещения дефектов костной ткани, может включать несколько последовательных стадий, таких как предварительная обработка биологического материала, грубая очистка и фракционирование, глубокая очистка и экстракция, делипидирование, ферментация, деминерализация и стерилизация в сверхкритических средах. Полученный биорезорбируемый биологический матрикс характеризуется повышенной остео- и биоинтеграцией, оптимальной скоростью биодеградации, высокой биосовместимостью, отсутствием иммунореактивности со стороны реципиента, высокой способностью к остеокондукции, выраженными остеогенными потенциями при остеосинтезе и костной пластике. Матрикс состоит из костного коллагена, гидроксиапатита и/или фосфата кальция и отличается тем, что костный коллаген представлен в нативной невосстановленной форме с полностью сохраненной трехмерной структурой, гидроксиапатит и фосфат кальция представлены в нативной аморфной форме, а сам матрикс, очищенный от клеточного дебриса, чужеродных липидов, нуклеиновых кислот и иммуногенов, содержит остаточные количества костных морфогенетических белков и импрегнирован везикулярным фосфатидилхолином и/или холестерином с включенным желатином (гидролизованным коллагеном), и/или костным ателоколлагеном, и/или поли-(-капролактоном) и дополнительно включенными биологически активными веществами (в том числе биоактивными пептидами и факторами роста).
EA201992185A 2017-03-17 2017-12-04 Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения EA201992185A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2017108893A RU2665962C1 (ru) 2017-03-17 2017-03-17 Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения
PCT/RU2017/050123 WO2018169442A1 (ru) 2017-03-17 2017-12-04 Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения

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US (1) US20210330862A1 (ru)
EP (1) EP3597200A4 (ru)
EA (1) EA201992185A1 (ru)
RU (1) RU2665962C1 (ru)
WO (1) WO2018169442A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL262473B (en) * 2018-10-18 2022-02-01 SAPOZNIKOV Larion Mammal-derived matrix as a bone replacement
RU2713803C1 (ru) * 2019-01-10 2020-02-07 Федеральное государственное бюджетное образовательное учреждение высшего образования "Амурская государственная медицинская академия" Министерства здравоохранения Российской Федерации Способ децеллюризации легкого для получения внеклеточного матрикса
RU2704114C1 (ru) * 2019-04-24 2019-10-24 Общество с ограниченной ответственностью "ЛИОСЕЛЛ" Способ получения минерально-органического компонента костной ткани
RU191700U1 (ru) * 2019-05-07 2019-08-16 Федеральное государственное бюджетное учреждение "Российский научный центр "Восстановительная травматология и ортопедия" имени академика Г.А. Илизарова" Министерства здравоохранения Российской Федерации Имплантат антимикробный для замещения костной ткани
RU2721604C1 (ru) * 2019-06-07 2020-05-21 Юрасова Юлия Борисовна Способ получения остеопластических биоматериалов из костной ткани
RU2722266C1 (ru) * 2019-09-13 2020-05-28 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр травматологии и ортопедии имени Р.Р. Вредена" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТО им. Р.Р. Вредена" Минздрава России) Лиофилизированный биологический биодеградируемый минерализованный костнопластический материал и способ его изготовления
RU2748991C1 (ru) * 2020-10-19 2021-06-02 Государственное бюджетное учреждение здравоохранения города Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы» (ГБУЗ "НИИ СП ИМ. Н.В.СКЛИФОСОВСКОГО ДЗМ") Способ насыщения коллагеном трансплантата костной ткани
RU2765927C1 (ru) * 2021-04-30 2022-02-04 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" Композитный матрикс для иммобилизации клеток в тканеподобной биоискусственной клеточной системе и способ его пространственной трансформации в процессе иммобилизации клеток
CN113750293A (zh) * 2021-10-15 2021-12-07 青岛蓝皓生物技术有限公司 骨修复材料的制备方法
CN116617471B (zh) * 2023-07-24 2023-10-13 成都贝施美医疗科技股份有限公司 一种具有双层结构的口腔胶原膜及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654625B1 (fr) * 1989-11-22 1992-02-21 Transphyto Sa Procede de fabrication d'un materiau pour osteoplastie a partir d'un tissu osseux naturel et materiau obtenu par ce procede.
US20030039678A1 (en) 1998-03-16 2003-02-27 Stone Kevin R. Xenograft bone matrix for orthopedic applications
US7357947B2 (en) 2001-09-10 2008-04-15 Biomet, Inc. Bone graft material incorporating demineralized bone matrix and lipids
US6565884B2 (en) 2001-09-10 2003-05-20 Interpore Cross International Bone graft material incorporating demineralized bone matrix and lipids
CA2433038A1 (en) 2001-10-12 2003-04-17 Osteotech, Inc. Bone graft compositions with improved growth factor stability
WO2005065396A2 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
RU2463081C2 (ru) 2005-08-26 2012-10-10 Риджентс Оф Дзе Юниверсити Оф Миннесота Удаление и восстановление содержания клеток в органах и тканях
WO2007053850A2 (en) * 2005-11-01 2007-05-10 Osteotech, Inc. Bone matrix compositions and methods
US8574825B2 (en) 2007-06-01 2013-11-05 Bacterin International, Inc. Process for demineralization of bone matrix with preservation of natural growth factors
WO2008157495A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Bone matrix compositions and methods
AU2008311785A1 (en) 2007-10-19 2009-04-23 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
CN102014977B (zh) * 2008-02-07 2015-09-02 生物模拟治疗有限责任公司 用于牵引成骨术的组合物和方法
KR101158338B1 (ko) 2010-05-14 2012-06-22 (주)다림티센 아텔로콜라겐 분리방법
KR101345704B1 (ko) 2011-09-29 2013-12-27 (주)시지바이오 섬유상 탈회골 기질의 제조방법
GB201215725D0 (en) * 2012-09-04 2012-10-17 Univ Leeds Composite connective tissue and bone implants
US9861662B2 (en) * 2013-07-03 2018-01-09 University of Pittsburgh—of the Commonwealth System of Higher Education Bone-derived extra cellular matrix gel
KR20170093105A (ko) 2014-09-19 2017-08-14 필립 제이 심슨 기질 혈관 분획 처리 디바이스 및 방법

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