EA201992185A1 - Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения - Google Patents
Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его полученияInfo
- Publication number
- EA201992185A1 EA201992185A1 EA201992185A EA201992185A EA201992185A1 EA 201992185 A1 EA201992185 A1 EA 201992185A1 EA 201992185 A EA201992185 A EA 201992185A EA 201992185 A EA201992185 A EA 201992185A EA 201992185 A1 EA201992185 A1 EA 201992185A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- bone
- matrix
- biological matrix
- collagen
- hydroxyapatite
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title abstract 6
- 239000011159 matrix material Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 108010035532 Collagen Proteins 0.000 abstract 3
- 102000008186 Collagen Human genes 0.000 abstract 3
- 229920001436 collagen Polymers 0.000 abstract 3
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 2
- 239000001506 calcium phosphate Substances 0.000 abstract 2
- 235000011010 calcium phosphates Nutrition 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 abstract 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 108010045569 atelocollagen Proteins 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 238000006065 biodegradation reaction Methods 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 229940112869 bone morphogenetic protein Drugs 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 230000015961 delipidation Effects 0.000 abstract 1
- 238000005115 demineralization Methods 0.000 abstract 1
- 230000002328 demineralizing effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000000399 orthopedic effect Effects 0.000 abstract 1
- 230000004820 osteoconduction Effects 0.000 abstract 1
- 230000002188 osteogenic effect Effects 0.000 abstract 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 1
- 229920001610 polycaprolactone Polymers 0.000 abstract 1
- 230000036515 potency Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
Classifications
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
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- General Chemical & Material Sciences (AREA)
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Abstract
Настоящее изобретение относится к медицинской биотехнологии, медицине, травматологии, ортопедии, стоматологии и ортодонтии. Предложенный способ получения биологического матрикса, предназначенного для замещения дефектов костной ткани, может включать несколько последовательных стадий, таких как предварительная обработка биологического материала, грубая очистка и фракционирование, глубокая очистка и экстракция, делипидирование, ферментация, деминерализация и стерилизация в сверхкритических средах. Полученный биорезорбируемый биологический матрикс характеризуется повышенной остео- и биоинтеграцией, оптимальной скоростью биодеградации, высокой биосовместимостью, отсутствием иммунореактивности со стороны реципиента, высокой способностью к остеокондукции, выраженными остеогенными потенциями при остеосинтезе и костной пластике. Матрикс состоит из костного коллагена, гидроксиапатита и/или фосфата кальция и отличается тем, что костный коллаген представлен в нативной невосстановленной форме с полностью сохраненной трехмерной структурой, гидроксиапатит и фосфат кальция представлены в нативной аморфной форме, а сам матрикс, очищенный от клеточного дебриса, чужеродных липидов, нуклеиновых кислот и иммуногенов, содержит остаточные количества костных морфогенетических белков и импрегнирован везикулярным фосфатидилхолином и/или холестерином с включенным желатином (гидролизованным коллагеном), и/или костным ателоколлагеном, и/или поли-(-капролактоном) и дополнительно включенными биологически активными веществами (в том числе биоактивными пептидами и факторами роста).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2017108893A RU2665962C1 (ru) | 2017-03-17 | 2017-03-17 | Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения |
PCT/RU2017/050123 WO2018169442A1 (ru) | 2017-03-17 | 2017-12-04 | Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения |
Publications (1)
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EA201992185A1 true EA201992185A1 (ru) | 2020-04-06 |
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EA201992185A EA201992185A1 (ru) | 2017-03-17 | 2017-12-04 | Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения |
Country Status (5)
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US (1) | US20210330862A1 (ru) |
EP (1) | EP3597200A4 (ru) |
EA (1) | EA201992185A1 (ru) |
RU (1) | RU2665962C1 (ru) |
WO (1) | WO2018169442A1 (ru) |
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IL262473B (en) * | 2018-10-18 | 2022-02-01 | SAPOZNIKOV Larion | Mammal-derived matrix as a bone replacement |
RU2713803C1 (ru) * | 2019-01-10 | 2020-02-07 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Амурская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Способ децеллюризации легкого для получения внеклеточного матрикса |
RU2704114C1 (ru) * | 2019-04-24 | 2019-10-24 | Общество с ограниченной ответственностью "ЛИОСЕЛЛ" | Способ получения минерально-органического компонента костной ткани |
RU191700U1 (ru) * | 2019-05-07 | 2019-08-16 | Федеральное государственное бюджетное учреждение "Российский научный центр "Восстановительная травматология и ортопедия" имени академика Г.А. Илизарова" Министерства здравоохранения Российской Федерации | Имплантат антимикробный для замещения костной ткани |
RU2721604C1 (ru) * | 2019-06-07 | 2020-05-21 | Юрасова Юлия Борисовна | Способ получения остеопластических биоматериалов из костной ткани |
RU2722266C1 (ru) * | 2019-09-13 | 2020-05-28 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр травматологии и ортопедии имени Р.Р. Вредена" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТО им. Р.Р. Вредена" Минздрава России) | Лиофилизированный биологический биодеградируемый минерализованный костнопластический материал и способ его изготовления |
RU2748991C1 (ru) * | 2020-10-19 | 2021-06-02 | Государственное бюджетное учреждение здравоохранения города Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы» (ГБУЗ "НИИ СП ИМ. Н.В.СКЛИФОСОВСКОГО ДЗМ") | Способ насыщения коллагеном трансплантата костной ткани |
RU2765927C1 (ru) * | 2021-04-30 | 2022-02-04 | Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" | Композитный матрикс для иммобилизации клеток в тканеподобной биоискусственной клеточной системе и способ его пространственной трансформации в процессе иммобилизации клеток |
CN113750293A (zh) * | 2021-10-15 | 2021-12-07 | 青岛蓝皓生物技术有限公司 | 骨修复材料的制备方法 |
CN116617471B (zh) * | 2023-07-24 | 2023-10-13 | 成都贝施美医疗科技股份有限公司 | 一种具有双层结构的口腔胶原膜及其制备方法 |
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FR2654625B1 (fr) * | 1989-11-22 | 1992-02-21 | Transphyto Sa | Procede de fabrication d'un materiau pour osteoplastie a partir d'un tissu osseux naturel et materiau obtenu par ce procede. |
US20030039678A1 (en) | 1998-03-16 | 2003-02-27 | Stone Kevin R. | Xenograft bone matrix for orthopedic applications |
US7357947B2 (en) | 2001-09-10 | 2008-04-15 | Biomet, Inc. | Bone graft material incorporating demineralized bone matrix and lipids |
US6565884B2 (en) | 2001-09-10 | 2003-05-20 | Interpore Cross International | Bone graft material incorporating demineralized bone matrix and lipids |
CA2433038A1 (en) | 2001-10-12 | 2003-04-17 | Osteotech, Inc. | Bone graft compositions with improved growth factor stability |
WO2005065396A2 (en) | 2003-12-31 | 2005-07-21 | Osteotech, Inc. | Improved bone matrix compositions and methods |
RU2463081C2 (ru) | 2005-08-26 | 2012-10-10 | Риджентс Оф Дзе Юниверсити Оф Миннесота | Удаление и восстановление содержания клеток в органах и тканях |
WO2007053850A2 (en) * | 2005-11-01 | 2007-05-10 | Osteotech, Inc. | Bone matrix compositions and methods |
US8574825B2 (en) | 2007-06-01 | 2013-11-05 | Bacterin International, Inc. | Process for demineralization of bone matrix with preservation of natural growth factors |
WO2008157495A2 (en) | 2007-06-15 | 2008-12-24 | Osteotech, Inc. | Bone matrix compositions and methods |
AU2008311785A1 (en) | 2007-10-19 | 2009-04-23 | Warsaw Orthopedic, Inc. | Demineralized bone matrix compositions and methods |
CN102014977B (zh) * | 2008-02-07 | 2015-09-02 | 生物模拟治疗有限责任公司 | 用于牵引成骨术的组合物和方法 |
KR101158338B1 (ko) | 2010-05-14 | 2012-06-22 | (주)다림티센 | 아텔로콜라겐 분리방법 |
KR101345704B1 (ko) | 2011-09-29 | 2013-12-27 | (주)시지바이오 | 섬유상 탈회골 기질의 제조방법 |
GB201215725D0 (en) * | 2012-09-04 | 2012-10-17 | Univ Leeds | Composite connective tissue and bone implants |
US9861662B2 (en) * | 2013-07-03 | 2018-01-09 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bone-derived extra cellular matrix gel |
KR20170093105A (ko) | 2014-09-19 | 2017-08-14 | 필립 제이 심슨 | 기질 혈관 분획 처리 디바이스 및 방법 |
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- 2017-12-04 EA EA201992185A patent/EA201992185A1/ru unknown
- 2017-12-04 EP EP17900746.3A patent/EP3597200A4/en not_active Withdrawn
- 2017-12-04 WO PCT/RU2017/050123 patent/WO2018169442A1/ru unknown
- 2017-12-04 US US16/607,729 patent/US20210330862A1/en not_active Abandoned
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EP3597200A1 (en) | 2020-01-22 |
US20210330862A1 (en) | 2021-10-28 |
WO2018169442A1 (ru) | 2018-09-20 |
RU2665962C1 (ru) | 2018-09-05 |
EP3597200A4 (en) | 2020-12-30 |
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