EA201991556A1 - Ингибиторы фосфодиэстеразы и способы лечения микробной инфекции - Google Patents

Ингибиторы фосфодиэстеразы и способы лечения микробной инфекции

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Publication number
EA201991556A1
EA201991556A1 EA201991556A EA201991556A EA201991556A1 EA 201991556 A1 EA201991556 A1 EA 201991556A1 EA 201991556 A EA201991556 A EA 201991556A EA 201991556 A EA201991556 A EA 201991556A EA 201991556 A1 EA201991556 A1 EA 201991556A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
microbial infection
phosphodiesthesis
inhibitors
treating microbial
Prior art date
Application number
EA201991556A
Other languages
English (en)
Inventor
Уилльям Майкл Галлатин
Грегори Н. Дитш
Original Assignee
Мавуфарма, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мавуфарма, Инк. filed Critical Мавуфарма, Инк.
Publication of EA201991556A1 publication Critical patent/EA201991556A1/ru

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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Abstract

В настоящем документе раскрыты способы и соединения для увеличения и усиления продукции IFN I типа in vivo. Согласно некоторым вариантам осуществления раскрытое в настоящем документе также включает способы активации и усиления cGAS-STING-ответа и применение ингибитора фосфодиэстеразы для лечения микробной инфекции.
EA201991556A 2016-12-22 2017-12-21 Ингибиторы фосфодиэстеразы и способы лечения микробной инфекции EA201991556A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662438344P 2016-12-22 2016-12-22
PCT/US2017/068044 WO2018119328A1 (en) 2016-12-22 2017-12-21 Phosphodiesterase inhibitors and methods of microbial treatment

Publications (1)

Publication Number Publication Date
EA201991556A1 true EA201991556A1 (ru) 2020-01-23

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EA201991556A EA201991556A1 (ru) 2016-12-22 2017-12-21 Ингибиторы фосфодиэстеразы и способы лечения микробной инфекции

Country Status (12)

Country Link
US (1) US20200085828A1 (ru)
EP (1) EP3558352A1 (ru)
JP (1) JP2020504740A (ru)
KR (1) KR20190126283A (ru)
CN (1) CN110446503A (ru)
AU (1) AU2017382297A1 (ru)
BR (1) BR112019012618A2 (ru)
CA (1) CA3047589A1 (ru)
EA (1) EA201991556A1 (ru)
IL (1) IL267455A (ru)
MX (1) MX2019007256A (ru)
WO (1) WO2018119328A1 (ru)

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CN109475570B (zh) 2016-03-18 2022-04-01 免疫传感器公司 环二核苷酸化合物及使用方法
AU2018294351B2 (en) 2017-06-30 2022-12-22 The Regents Of The University Of California Compositions and methods for modulating hair growth
EP3676254A4 (en) * 2017-08-31 2021-01-13 AbbVie Inc. ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF
WO2020150147A1 (en) * 2019-01-14 2020-07-23 The Regents Of The University Of California Compositions and methods for treating ocular conditions
CN113924092A (zh) * 2019-03-19 2022-01-11 斯汀格瑞治疗股份有限公司 喹啉和喹唑啉化合物以及其使用方法
MX2021012305A (es) * 2019-04-12 2021-11-12 Riboscience Llc Derivados de heteroarilos biciclicos como inhibidores de ectonucleotido pirofosfatasa fosfodiesterasa 1.
KR102643239B1 (ko) * 2020-03-11 2024-03-05 사회복지법인 삼성생명공익재단 포스포디에스터레이즈 5 억제제를 포함하는, nk-t 세포 림프종 또는 nk 세포 백혈병 예방 또는 치료용 약학적 조성물
WO2021225407A1 (ko) 2020-05-08 2021-11-11 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도
KR102682428B1 (ko) 2020-05-08 2024-07-05 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도
CN116348451A (zh) * 2020-05-14 2023-06-27 维艾尔生物科技有限公司 Enpp1调节剂及其用途
KR20220095154A (ko) 2020-12-29 2022-07-06 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도
CA3200386A1 (en) 2020-12-29 2022-07-07 Seo Jung Han Novel naphthyridinone derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase and use thereof
KR102686866B1 (ko) 2021-01-29 2024-07-19 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도
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KR102635126B1 (ko) 2021-05-27 2024-02-13 한국과학기술연구원 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 피롤로피리미딘 유도체 및 이들의 용도
KR20230090463A (ko) 2021-12-15 2023-06-22 한국과학기술연구원 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 피리도피리미딘 유도체 및 이들의 용도
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WO2018119328A1 (en) 2018-06-28
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