EA201892461A1 - Продукт бензодиазепина с активностью на центральную нервную и сердечно-сосудистую системы - Google Patents

Продукт бензодиазепина с активностью на центральную нервную и сердечно-сосудистую системы

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Publication number
EA201892461A1
EA201892461A1 EA201892461A EA201892461A EA201892461A1 EA 201892461 A1 EA201892461 A1 EA 201892461A1 EA 201892461 A EA201892461 A EA 201892461A EA 201892461 A EA201892461 A EA 201892461A EA 201892461 A1 EA201892461 A1 EA 201892461A1
Authority
EA
Eurasian Patent Office
Prior art keywords
central nervous
benzodiazepin
activity
product
diseases
Prior art date
Application number
EA201892461A
Other languages
English (en)
Inventor
Яниэр Нунез Фигуэредо
Майлин Вонг Гуерра
Луис Артуро Фонзека Фонзека
Барбара Беатрис Гарридо Суарез
Дженей Рамирез Санчез
Гилберто Лазаро Пардо Андреу
Ямила Вердеция Рейес
Эстаел Очоа Родригуес
Педро Жильберто Барзага Фернандес
Никте Гонзалез Алфонсо
Рене Делгадо Хернандез
Падрон Якис Алехандро Саул
Original Assignee
Универсидад Де Ла Гавана
Сентро Де Инвестигасион И Десаррольо Де Медикаментос Сидем
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Универсидад Де Ла Гавана, Сентро Де Инвестигасион И Десаррольо Де Медикаментос Сидем filed Critical Универсидад Де Ла Гавана
Publication of EA201892461A1 publication Critical patent/EA201892461A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Соединение формулы III, его продукты и фармацевтические композиции, содержащие их, для лечения заболеваний центральной нервной и сосудистой систем, в частности нейродегенеративных расстройств с нарушением когнитивных функций, заболеваний, связанных с окислительным стрессом, заболеваний, принимающих участие в митохондриальной дисфункции, болезни Паркинсона и невропатической боли, а также патологических процессов, связанных со старением.
EA201892461A 2016-05-04 2017-05-03 Продукт бензодиазепина с активностью на центральную нервную и сердечно-сосудистую системы EA201892461A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CUP2016000058A CU20160058A7 (es) 2016-05-04 2016-05-04 Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular
PCT/CU2017/050002 WO2017190713A1 (es) 2016-05-04 2017-05-03 Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular

Publications (1)

Publication Number Publication Date
EA201892461A1 true EA201892461A1 (ru) 2019-04-30

Family

ID=59215419

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892461A EA201892461A1 (ru) 2016-05-04 2017-05-03 Продукт бензодиазепина с активностью на центральную нервную и сердечно-сосудистую системы

Country Status (20)

Country Link
US (1) US11098039B2 (ru)
EP (1) EP3470414B1 (ru)
JP (1) JP7078959B2 (ru)
KR (1) KR102428383B1 (ru)
CN (1) CN110114356B (ru)
AR (1) AR108369A1 (ru)
AU (1) AU2017259748B2 (ru)
BR (1) BR112018072588B1 (ru)
CA (1) CA3023105C (ru)
CL (1) CL2018003113A1 (ru)
CU (1) CU20160058A7 (ru)
DK (1) DK3470414T3 (ru)
EA (1) EA201892461A1 (ru)
ES (1) ES2902992T3 (ru)
MX (1) MX2018013405A (ru)
NZ (1) NZ748959A (ru)
SG (1) SG11201809845TA (ru)
SI (1) SI3470414T1 (ru)
WO (1) WO2017190713A1 (ru)
ZA (1) ZA201808162B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021139842A2 (es) 2019-12-26 2021-07-15 Centro de Investigación Y Desarrollo de Medicamentos CIDEM Uso de un derivado benzodiacepínico y método de tratamiento del trauma craneoencefálico
CU20190114A7 (es) 2019-12-26 2021-08-06 Centro De Investig Y Desarrollo De Medicamentos Cidem Combinación para simultáneamente incrementar la eficacia analgésica de la morfina y reducir su dependencia física

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110288070A1 (en) * 2008-05-05 2011-11-24 ROGERS Kathryn Methods for treating cognitive disorders using inhibitors of histone deacetylase
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
CU24576B1 (es) 2016-05-04 2022-02-04 Centro De Investig Y Desarrollo De Medicamentos Cidem Compuesto fenólico y combinación del mismo con una benzodiazepina fusionada a 1,4-dihidropiridina para el tratamiento de afecciones del sistema nervioso central y vascular

Also Published As

Publication number Publication date
EP3470414B1 (en) 2021-10-13
WO2017190713A1 (es) 2017-11-09
AU2017259748A1 (en) 2018-12-20
EP3470414A1 (en) 2019-04-17
NZ748959A (en) 2024-02-23
KR20210025137A (ko) 2021-03-09
MX2018013405A (es) 2019-08-16
CN110114356A (zh) 2019-08-09
BR112018072588B1 (pt) 2024-02-20
CA3023105C (en) 2023-07-18
BR112018072588A2 (pt) 2019-02-19
JP2019519600A (ja) 2019-07-11
AR108369A1 (es) 2018-08-15
AU2017259748B2 (en) 2021-08-05
ZA201808162B (en) 2021-08-25
KR102428383B1 (ko) 2022-08-02
CL2018003113A1 (es) 2019-04-12
CU20160058A7 (es) 2017-12-08
SI3470414T1 (sl) 2022-03-31
CN110114356B (zh) 2021-09-24
US11098039B2 (en) 2021-08-24
SG11201809845TA (en) 2018-12-28
JP7078959B2 (ja) 2022-06-01
ES2902992T3 (es) 2022-03-30
DK3470414T3 (da) 2022-01-17
US20190270738A1 (en) 2019-09-05
CA3023105A1 (en) 2017-11-09

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