EA201891988A1 - Ингибиторы mcl-1 на основе замещенных индолов - Google Patents

Ингибиторы mcl-1 на основе замещенных индолов

Info

Publication number
EA201891988A1
EA201891988A1 EA201891988A EA201891988A EA201891988A1 EA 201891988 A1 EA201891988 A1 EA 201891988A1 EA 201891988 A EA201891988 A EA 201891988A EA 201891988 A EA201891988 A EA 201891988A EA 201891988 A1 EA201891988 A1 EA 201891988A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mcl
inhibitors based
indols
substituted
present
Prior art date
Application number
EA201891988A
Other languages
English (en)
Other versions
EA038143B1 (ru
Inventor
Таекиу Ли
Джеймс С. Тарр
Киок Дзеон
Джеймс М. Салович
Субрата Шо
Нагаратханам Вирасами
Квангхо Ким
Пламен П. Христов
Эдвард Т. Олейничак
Бинь ЧЖАО
Стефен В. Фесик
Чжиго Бянь
Original Assignee
Вандербилт Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вандербилт Юниверсити filed Critical Вандербилт Юниверсити
Publication of EA201891988A1 publication Critical patent/EA201891988A1/ru
Publication of EA038143B1 publication Critical patent/EA038143B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

В настоящем изобретении предусмотрены соединения, которые подавляют активность антиапоптотического белка 1, ассоциированного с миелоидным лейкозом (Mcl-1), представителя семейства Bcl-2. В настоящем изобретении также предусмотрены фармацевтические композиции, а также способы применения соединений для лечения заболеваний и состояний (например, рака), характеризующихся сверхэкспрессией или дисрегуляцией белка Mcl-1.
EA201891988A 2016-03-04 2017-03-03 ИНГИБИТОРЫ Mcl-1 НА ОСНОВЕ ЗАМЕЩЕННЫХ ИНДОЛОВ EA038143B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662304124P 2016-03-04 2016-03-04
US201662402903P 2016-09-30 2016-09-30
PCT/US2017/020699 WO2017152076A1 (en) 2016-03-04 2017-03-03 Substituted indole mcl-1 inhibitors

Publications (2)

Publication Number Publication Date
EA201891988A1 true EA201891988A1 (ru) 2019-02-28
EA038143B1 EA038143B1 (ru) 2021-07-13

Family

ID=59744491

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891988A EA038143B1 (ru) 2016-03-04 2017-03-03 ИНГИБИТОРЫ Mcl-1 НА ОСНОВЕ ЗАМЕЩЕННЫХ ИНДОЛОВ

Country Status (14)

Country Link
US (2) US11596639B2 (ru)
EP (2) EP3423435B1 (ru)
JP (1) JP7086395B2 (ru)
KR (1) KR102396177B1 (ru)
CN (1) CN109153643B (ru)
AU (1) AU2017228385B2 (ru)
BR (1) BR112018067775B1 (ru)
CA (1) CA3016182C (ru)
CL (1) CL2018002516A1 (ru)
EA (1) EA038143B1 (ru)
IL (1) IL261231B (ru)
MX (1) MX2018010678A (ru)
PH (1) PH12018501877A1 (ru)
WO (1) WO2017152076A1 (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3572416B1 (en) 2014-01-24 2022-09-21 Turning Point Therapeutics, Inc. Diaryl macrocycles as modulators of protein kinases
EP3122353B1 (en) 2014-03-27 2020-10-28 Vanderbilt University Substituted indole mcl-1 inhibitors
RU2732405C2 (ru) 2015-07-02 2020-09-16 Тёрнинг Поинт Терапьютикс, Инк. Хиральные диарильные макроциклы в качестве модуляторов протеинкиназ
EP3214092A1 (en) 2016-03-04 2017-09-06 Bayer Pharma Aktiengesellschaft Prodrugs of the selective progesterone receptor modulator (sprm) (11.beta.,17.beta.)-17-hydroxy-11-[4-(methylsulphonyl)phenyl]-17-(pentafluoroethyl)estra-4,9-dien-3-one
CN109715632B (zh) 2016-05-19 2021-10-26 拜尔公开股份有限公司 大环吲哚衍生物
CN111757884B (zh) 2017-11-17 2023-12-19 拜耳股份公司 取代的大环吲哚衍生物
EP3710449B1 (en) 2017-11-17 2022-07-06 The Broad Institute, Inc. Macrocyclic fluorine substituted indole derivatives as mcl-1 inhibitors, for use in the treatment of cancer
US11447504B2 (en) 2017-11-17 2022-09-20 Bayer Aktiengesellschaft Macrocyclic chlorine substituted indole derivatives
US11478451B1 (en) 2017-11-17 2022-10-25 Bayer Aktiengesellschaft Macrocyclic chlorine substituted indole derivatives
EP3710456B1 (en) * 2017-11-17 2022-09-21 The Broad Institute, Inc. Macrocyclic indole derivatives
US11760701B2 (en) 2018-02-27 2023-09-19 The Research Foundation For The State University Of New Yrok Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
WO2020048548A1 (zh) * 2018-09-07 2020-03-12 正大天晴药业集团股份有限公司 一种作用于crbn蛋白的三并环类化合物
CN111904958B (zh) * 2019-05-09 2022-09-13 浙江大学 Umi-77作为线粒体自噬诱导剂在制备治疗炎症及神经退行性疾病药物中的应用
JP7209897B2 (ja) * 2019-09-12 2023-01-20 メッドシャイン ディスカバリー インコーポレイテッド Ｃｒｂｎタンパク質モジュレーターとしての二環式化合物
US20220402893A1 (en) 2019-11-25 2022-12-22 Unimatec Co., Ltd. Fluorine-containing pyrimidine compound and method for producing same
CN116710430A (zh) * 2020-05-12 2023-09-05 皮姆维制药公司 用于恢复突变p53功能的方法和化合物
CN113512025B (zh) * 2020-07-31 2023-01-06 四川大学 一种吲唑酯类化合物及其制药用途
CN115785014A (zh) * 2022-12-27 2023-03-14 瑞石生物医药有限公司 四唑衍生物及其用途

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703053A (en) 1985-10-28 1987-10-27 Warner-Lambert Company Benzothiophenes and benzofurans and antiallergic use thereof
GB8531612D0 (en) 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
US4994477A (en) 1988-03-24 1991-02-19 Abbott Laboratories Heterocyclic renin inhibitors
DE4128015A1 (de) 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
EP0639573A1 (de) 1993-08-03 1995-02-22 Hoechst Aktiengesellschaft Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament
US5436264A (en) 1993-08-19 1995-07-25 Syntex (U.S.A.) Inc. N-aryloxyalkyl tryptamine α1 -adrenergic receptor antagonists
JP3739432B2 (ja) 1994-02-25 2006-01-25 ダイセル化学工業株式会社 オゾン開裂反応
WO1997042188A1 (fr) 1996-05-08 1997-11-13 Kumiai Chemical Industry Co., Ltd. Derives d'uracile a substitution indolyle et herbicides contenant ces derives en tant qu'ingredients actifs
EP0929311B8 (en) 1996-09-12 2006-02-01 Idun Pharmaceuticals, Inc. INHIBITION OF APOPTOSIS USING INTERLEUKIN-1 beta-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS
FR2761070B1 (fr) 1997-03-20 1999-04-23 Synthelabo Derives de dihydropyrazino[1,2-a]indole-1-one, leur preparation et leur application en therapeutique
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
PL366068A1 (en) 2000-10-10 2005-01-24 Smithkline Beecham Corporation Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppar-gamma binding agents
FR2827287B1 (fr) 2001-07-13 2003-10-31 Servier Lab Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN1886133B (zh) 2003-12-04 2010-12-01 财团法人卫生研究院 吲哚化合物
US7429611B2 (en) 2004-09-23 2008-09-30 Bristol-Myers Squibb Company Indole inhibitors of 15-lipoxygenase
US8097644B2 (en) 2006-03-28 2012-01-17 Allergan, Inc. Indole compounds having sphingosine-1-phosphate (S1P) receptor antagonist
DE102006033109A1 (de) 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
CN101636386A (zh) 2006-12-14 2010-01-27 安斯泰来制药有限公司 用作crth2拮抗剂和抗过敏剂的多环酸化合物
CA2682354C (en) 2007-04-16 2016-12-13 Abbott Laboratories 7-nonsubstituted indole mcl-1 inhibitors
CN101743224A (zh) * 2007-04-16 2010-06-16 雅培制药有限公司 7-取代的吲哚mcl-1抑制剂
US20090270497A1 (en) 2008-04-24 2009-10-29 Pharmacyclics, Inc. Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors
EP2161266A1 (en) 2008-08-22 2010-03-10 EVOTEC Neurosciences GmbH Benzofuran derivatives as orexin receptor antagonists
EP2358748B1 (en) 2008-12-09 2016-07-06 Dana-Farber Cancer Institute, Inc. Methods and compositions for specific modulation of mcl-1
FR2961393B1 (fr) 2010-06-16 2013-02-15 Oreal Procede de coloration capillaire a partir d'une composition comprenant au moins un compose indolique ou une indolinique, un sel metallique, du peroxyde d'hydrogene et un agent alcalinisant
CA2810499A1 (en) 2010-09-08 2012-03-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Educatio N P53-mdm2 antagonists
WO2013078544A1 (en) 2011-11-29 2013-06-06 Beta Pharma Canada Inc. Heterocyclic amides compounds which are hdac6 inhibitors and used as anti-tumoral agents
WO2013112878A1 (en) 2012-01-26 2013-08-01 The Penn State Research Foundation Mcl-1 modulating compositions
WO2014047427A2 (en) 2012-09-21 2014-03-27 Vanderbilt University Substituted benzofuran, benzothiophene and indole mcl-1 inhibitors
US10005728B2 (en) * 2013-08-28 2018-06-26 Vanderbilt University Substituted indole Mcl-1 inhibitors
EP3122353B1 (en) 2014-03-27 2020-10-28 Vanderbilt University Substituted indole mcl-1 inhibitors

Also Published As

Publication number Publication date
KR102396177B1 (ko) 2022-05-09
CL2018002516A1 (es) 2019-02-01
IL261231A (en) 2018-10-31
EA038143B1 (ru) 2021-07-13
JP2019513697A (ja) 2019-05-30
JP7086395B2 (ja) 2022-06-20
EP3423435A4 (en) 2019-08-14
EP4292662A2 (en) 2023-12-20
CN109153643A (zh) 2019-01-04
US11596639B2 (en) 2023-03-07
CN109153643B (zh) 2022-06-21
BR112018067775B1 (pt) 2024-02-15
EP3423435A1 (en) 2019-01-09
PH12018501877A1 (en) 2019-02-04
EP3423435B1 (en) 2023-08-23
CA3016182C (en) 2024-02-27
WO2017152076A1 (en) 2017-09-08
AU2017228385A1 (en) 2018-09-06
KR20180118199A (ko) 2018-10-30
BR112018067775A2 (pt) 2019-04-09
EP4292662A3 (en) 2024-02-21
IL261231B (en) 2021-10-31
US20210283138A1 (en) 2021-09-16
MX2018010678A (es) 2019-01-17
AU2017228385B2 (en) 2021-11-04
CA3016182A1 (en) 2017-09-08
US20230330099A1 (en) 2023-10-19

Similar Documents

Publication Publication Date Title
EA201891988A1 (ru) Ингибиторы mcl-1 на основе замещенных индолов
PH12021551065A1 (en) Fused ring compounds
PH12021500014A1 (en) Fused ring compounds
EA201990495A1 (ru) Биарильные соединения, применимые в качестве иммуномодуляторов
EA201990912A1 (ru) Анти-lag-3 антитела и их композиции
EA201890725A1 (ru) Агонисты фарнезоидного х-рецептора и их применение
EA201990019A1 (ru) Соединения и композиции для подавления активности shp2
EA201891974A1 (ru) Ингибиторы связывания белка wdr5 с белками
EA202191668A1 (ru) Гетероциклил пиридазин в качестве фунгицидных соединений
EA201990187A1 (ru) Антипролиферационные средства на основе пиримидина
EA201790492A1 (ru) СОЕДИНЕНИЯ, КОТОРЫЕ ИНГИБИРУЮТ БЕЛОК Mcl-1
EA201892666A1 (ru) 3-оксо-2,6-дифенил-2,3-дигидропиридазин-4-карбоксамиды
EA201792047A1 (ru) Новые соединения
EA201691134A1 (ru) Новые ингибиторы глутаминазы
EA201792231A1 (ru) Ингибиторы индоламин-2,3-диоксигеназы и способы их применения
EA201691857A1 (ru) Соединения, применимые в качестве иммуномодуляторов
EA201591823A1 (ru) Ингибиторы ido
BR112019017403A2 (pt) composições e métodos para o tratamento de câncer
EA202092086A1 (ru) Ингибиторы аргиназы
PH12019502363A1 (en) Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl compounds
EA201990400A1 (ru) Соединения и композиции и их применение
EA202191476A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA202191478A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA202090414A1 (ru) Соединения и их применение
EA202190588A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина