EA201891467A1 - Сокристалл, способ его получения и лекарственное средство, содержащее сокристалл - Google Patents

Сокристалл, способ его получения и лекарственное средство, содержащее сокристалл

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Publication number
EA201891467A1
EA201891467A1 EA201891467A EA201891467A EA201891467A1 EA 201891467 A1 EA201891467 A1 EA 201891467A1 EA 201891467 A EA201891467 A EA 201891467A EA 201891467 A EA201891467 A EA 201891467A EA 201891467 A1 EA201891467 A1 EA 201891467A1
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EA
Eurasian Patent Office
Prior art keywords
acid
sokrystal
skrystal
preparation
medicine containing
Prior art date
Application number
EA201891467A
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English (en)
Other versions
EA039213B1 (ru
Inventor
Койа Кимото
Мицуо Ямамото
Масато Китаяма
Ясухиро Саваи
Миюки Хохокабе
Кентаро Ивата
Original Assignee
Такеда Фармасьютикал Компани Лимитед
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Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Publication of EA201891467A1 publication Critical patent/EA201891467A1/ru
Publication of EA039213B1 publication Critical patent/EA039213B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/08—Malonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C07C59/50—Mandelic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C07C65/10—Salicylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение представляет сокристалл (S)-3-(1-((1-акрилоилпирролидин-3-ил)окси)изохинолин-3-ил)-1H-1,2,4-триазол-5(4H)-она и органической кислоты, способной формировать сокристалл с данным соединением. Характерными полученными сокристаллами являются сокристаллы с гентизиновой кислотой, салициловой кислотой, малеиновой кислотой, малоновой кислотой, яблочной кислотой, миндальной кислотой и лимонной кислотой.
EA201891467A 2015-12-24 2016-12-22 Сокристалл, способ его получения и лекарственное средство, содержащее сокристалл EA039213B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015252658 2015-12-24
PCT/JP2016/089224 WO2017111179A1 (en) 2015-12-24 2016-12-22 Cocrystal, production method thereof, and medicament containing cocrystal

Publications (2)

Publication Number Publication Date
EA201891467A1 true EA201891467A1 (ru) 2018-12-28
EA039213B1 EA039213B1 (ru) 2021-12-17

Family

ID=57910088

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891467A EA039213B1 (ru) 2015-12-24 2016-12-22 Сокристалл, способ его получения и лекарственное средство, содержащее сокристалл

Country Status (25)

Country Link
US (1) US10836745B2 (ru)
EP (1) EP3394045B1 (ru)
JP (1) JP6876704B2 (ru)
KR (1) KR102687603B1 (ru)
CN (1) CN108473467B (ru)
AR (1) AR107132A1 (ru)
AU (1) AU2016375899B2 (ru)
CA (1) CA3009610C (ru)
CL (1) CL2018001725A1 (ru)
CO (1) CO2018006473A2 (ru)
DK (1) DK3394045T3 (ru)
EA (1) EA039213B1 (ru)
EC (1) ECSP18055921A (ru)
ES (1) ES2877089T3 (ru)
HK (1) HK1256362A1 (ru)
IL (1) IL260195A (ru)
MX (1) MX2018007721A (ru)
PH (1) PH12018501356A1 (ru)
PL (1) PL3394045T3 (ru)
SG (1) SG11201805331QA (ru)
TN (1) TN2018000221A1 (ru)
TW (1) TWI722080B (ru)
UY (1) UY37046A (ru)
WO (1) WO2017111179A1 (ru)
ZA (1) ZA201804393B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019071254A1 (en) * 2017-10-06 2019-04-11 Cargill, Incorporated STEVIOL GLYCOSIDE SOLUBILITY AMPLIFIERS
CN111372468A (zh) 2017-10-06 2020-07-03 嘉吉公司 甜菊醇糖苷溶解度增强剂
WO2020210118A1 (en) 2019-04-06 2020-10-15 Cargill, Incorporated Sensory modifiers
CN110818692B (zh) * 2019-11-08 2023-03-24 中国海洋大学 一种替加氟与丁香酸的共晶及其制备方法
TWI845802B (zh) * 2020-04-21 2024-06-21 健亞生物科技股份有限公司 硫酸羥氯喹之晶體

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
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PL189317B1 (pl) 1997-10-07 2005-07-29 Schering Corp Krystaliczny przeciwgrzybiczy polimorf (-)-4-[4-[4-[4-[(2R-cis)-5-(2,4-difluorofenylo)tetrahydro-5-(1H-1,2,4-triazol-1-ilo-metylo)furan-3-ilo]metoksy]fenylo]-1-piperazynylo]fenylo-2,4-dihydro-2-[(S)-1-etylo-2(S)-hydroksypropylo]-3H-1,2,4-triazol-3-onu
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JO3377B1 (ar) 2013-03-11 2019-03-13 Takeda Pharmaceuticals Co مشتقات بيريدينيل وبيريدينيل مندمج

Also Published As

Publication number Publication date
HK1256362A1 (zh) 2019-09-20
PH12018501356A1 (en) 2019-02-18
UY37046A (es) 2017-07-31
EA039213B1 (ru) 2021-12-17
ES2877089T3 (es) 2021-11-16
CO2018006473A2 (es) 2018-07-10
WO2017111179A1 (en) 2017-06-29
JP6876704B2 (ja) 2021-05-26
IL260195A (en) 2018-07-31
SG11201805331QA (en) 2018-07-30
KR102687603B1 (ko) 2024-07-24
US10836745B2 (en) 2020-11-17
KR20180095933A (ko) 2018-08-28
PL3394045T3 (pl) 2021-09-27
CN108473467B (zh) 2021-08-13
CL2018001725A1 (es) 2018-10-19
EP3394045B1 (en) 2021-05-19
EP3394045A1 (en) 2018-10-31
AR107132A1 (es) 2018-03-21
AU2016375899B2 (en) 2021-05-13
TWI722080B (zh) 2021-03-21
DK3394045T3 (da) 2021-08-16
TW201730181A (zh) 2017-09-01
TN2018000221A1 (en) 2019-10-04
CA3009610A1 (en) 2017-06-29
ZA201804393B (en) 2019-09-25
CN108473467A (zh) 2018-08-31
US20170183326A1 (en) 2017-06-29
BR112018012915A2 (pt) 2018-12-11
MX2018007721A (es) 2018-08-15
ECSP18055921A (es) 2018-10-31
CA3009610C (en) 2024-02-13
JP2019504025A (ja) 2019-02-14
AU2016375899A1 (en) 2018-07-19

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