EA201891322A1 - Анти-tl1a/анти-tnf-альфа биспецифические антигенсвязывающие белки и их применение - Google Patents

Анти-tl1a/анти-tnf-альфа биспецифические антигенсвязывающие белки и их применение

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Publication number
EA201891322A1
EA201891322A1 EA201891322A EA201891322A EA201891322A1 EA 201891322 A1 EA201891322 A1 EA 201891322A1 EA 201891322 A EA201891322 A EA 201891322A EA 201891322 A EA201891322 A EA 201891322A EA 201891322 A1 EA201891322 A1 EA 201891322A1
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EA
Eurasian Patent Office
Prior art keywords
tl1a
binding proteins
antigen
tnf
directed
Prior art date
Application number
EA201891322A
Other languages
English (en)
Inventor
Хайлин Хсу
Гунасекаран Каннан
Кеннет В. Уолкер
Мишель Хорттер
Эдвард Дж. Белоуски
Original Assignee
Амген Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2016/052006 external-priority patent/WO2017049004A1/en
Application filed by Амген Инк. filed Critical Амген Инк.
Publication of EA201891322A1 publication Critical patent/EA201891322A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms

Abstract

Данное изобретение относится к антигенсвязывающим белкам, которые связываются с TL1A, включая биспецифические антигенсвязывающие белки (например, антитела) к TL1A и TNF-α. Такие биспецифические антитела могут иметь формат тетрамерного иммуноглобулина, в котором одна пара тяжелой цепи-легкой цепи антитела направлена на TL1A, а другая - на TNF-α. Указанные биспецифические антигенсвязывающие белки дополнительно могут иметь формат гибрида IgG-scFv, в котором обычное тетрамерное антитело, направленное на один антиген, слито с парой одноцепочечных блоков Fv, направленных на другой антиген. Указанный биспецифический антигенсвязывающий белок может иметь формат гибрида IgG-Fab, в котором молекула Fab, связывающаяся с одним антигеном, слита с каждой тяжелой цепью обычного тетрамерного антитела, направленного на другой антиген. Данное изобретение дополнительно относится к применению анти-TL1A связывающих белков и анти-TL1A/анти-TNF-альфа антигенсвязывающих белков и фармацевтических готовых форм на их основе.
EA201891322A 2015-12-16 2016-12-14 Анти-tl1a/анти-tnf-альфа биспецифические антигенсвязывающие белки и их применение EA201891322A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562268432P 2015-12-16 2015-12-16
US201662333063P 2016-05-06 2016-05-06
PCT/US2016/052006 WO2017049004A1 (en) 2015-09-15 2016-09-15 Tetravalent bispecific and tetraspecific antigen binding proteins and uses thereof
PCT/US2016/066722 WO2017106383A1 (en) 2015-12-16 2016-12-14 Anti-tl1a/anti-tnf-alpha bispecific antigen binding proteins and uses thereof

Publications (1)

Publication Number Publication Date
EA201891322A1 true EA201891322A1 (ru) 2019-01-31

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Country Status (24)

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US (2) US11104745B2 (ru)
EP (1) EP3390444A1 (ru)
JP (1) JP7263007B2 (ru)
KR (1) KR20180099723A (ru)
CN (1) CN109311971A (ru)
AU (2) AU2016370659B2 (ru)
BR (1) BR112018012096A2 (ru)
CA (1) CA3008267A1 (ru)
CL (3) CL2018001596A1 (ru)
CO (1) CO2018007355A2 (ru)
CR (1) CR20180365A (ru)
EA (1) EA201891322A1 (ru)
IL (1) IL259847A (ru)
JO (1) JO3816B1 (ru)
MA (1) MA44060A (ru)
MX (1) MX2018007424A (ru)
PH (1) PH12018501284A1 (ru)
SG (2) SG10201912002YA (ru)
TN (1) TN2019000275A1 (ru)
TW (1) TWI799368B (ru)
UA (1) UA124305C2 (ru)
UY (1) UY37027A (ru)
WO (1) WO2017106383A1 (ru)
ZA (1) ZA201904491B (ru)

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CN109311971A (zh) 2019-02-05
JO3816B1 (ar) 2021-01-31
CL2023002597A1 (es) 2024-03-15
SG11201804857WA (en) 2018-07-30
US11104745B2 (en) 2021-08-31
SG10201912002YA (en) 2020-02-27
ZA201904491B (en) 2020-03-25
UY37027A (es) 2017-06-30
IL259847A (en) 2018-07-31
US20220213226A1 (en) 2022-07-07
EP3390444A1 (en) 2018-10-24
CA3008267A1 (en) 2017-06-22
JP2019502692A (ja) 2019-01-31
AU2024200534A1 (en) 2024-04-11
PH12018501284A1 (en) 2019-01-28
JP7263007B2 (ja) 2023-04-24
CO2018007355A2 (es) 2018-07-19
WO2017106383A4 (en) 2017-09-08
US20190119407A1 (en) 2019-04-25
KR20180099723A (ko) 2018-09-05
CL2021001179A1 (es) 2021-11-19
WO2017106383A1 (en) 2017-06-22
TN2019000275A1 (en) 2021-05-07
UA124305C2 (uk) 2021-08-25
MA44060A (fr) 2018-10-24
AU2016370659B2 (en) 2024-02-15
MX2018007424A (es) 2018-09-21
TW201731871A (zh) 2017-09-16
CR20180365A (es) 2018-09-28
CL2018001596A1 (es) 2018-09-28
TWI799368B (zh) 2023-04-21
BR112018012096A2 (pt) 2018-11-27
AU2016370659A1 (en) 2018-06-28

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