EA201890963A1 - Соли палбоциклиба - Google Patents
Соли палбоциклибаInfo
- Publication number
- EA201890963A1 EA201890963A1 EA201890963A EA201890963A EA201890963A1 EA 201890963 A1 EA201890963 A1 EA 201890963A1 EA 201890963 A EA201890963 A EA 201890963A EA 201890963 A EA201890963 A EA 201890963A EA 201890963 A1 EA201890963 A1 EA 201890963A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- salt
- palbocyclib
- monohydrate
- palbocyclyb
- palbocyclic
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 15
- 150000004682 monohydrates Chemical class 0.000 abstract 9
- -1 dihydrate salt Chemical class 0.000 abstract 3
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 150000002688 maleic acid derivatives Chemical class 0.000 abstract 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical class C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 abstract 1
- 150000003891 oxalate salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Предмет данного изобретения относится к разным новым солям палбоциклиба, кроме того, к их гидратным и сольватным формам, таким как бромоводородная соль палбоциклиба (1:1), дигидратная соль бромоводорода палбоциклиба (1:2), форма E гидрохлоридной соли палбоциклиба (1:1), дигидратная соль сульфата палбоциклиба (2:1), камзилатная соль палбоциклиба (1:1), напзилатная соль палбоциклиба (1:1), дигидратная соль напзилата палбоциклиба (1:2), тозилатная соль палбоциклиба (1:1), моногидратная соль цитрата палбоциклиба (1:1), форма I малеатной соли палбоциклиба (1:1), форма II малеатной соли палбоциклиба (1:1) и оксалатная соль палбоциклиба (1:1). Предмет данного изобретения также относится к получению указанных выше солей палбоциклиба, лекарственных препаратов, содержащих эти соли, и применению в медицине указанных выше форм.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1500506A HU230962B1 (hu) | 2015-10-28 | 2015-10-28 | Palbociclib sók |
| PCT/HU2016/050050 WO2017072543A1 (en) | 2015-10-28 | 2016-10-26 | Palbociclib salts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201890963A1 true EA201890963A1 (ru) | 2018-09-28 |
| EA035346B1 EA035346B1 (ru) | 2020-05-29 |
Family
ID=89991966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201890963A EA035346B1 (ru) | 2015-10-28 | 2016-10-26 | Соль 4-толуолсульфоновой кислоты и палбоциклиба, способ её получения и её применение в медицине |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP3368527B1 (ru) |
| EA (1) | EA035346B1 (ru) |
| ES (1) | ES2875402T3 (ru) |
| HU (2) | HU230962B1 (ru) |
| LT (1) | LT3368527T (ru) |
| PL (1) | PL3368527T3 (ru) |
| UA (1) | UA123218C2 (ru) |
| WO (1) | WO2017072543A1 (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109575021B (zh) * | 2019-01-22 | 2020-09-18 | 北京海美桐医药科技有限公司 | 一种哌柏西利的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101001857B (zh) | 2002-01-22 | 2011-06-22 | 沃尼尔·朗伯有限责任公司 | 2-(吡啶-2-基氨基)-吡啶并[2,3-d]嘧啶-7-酮 |
| CN1835951B (zh) * | 2003-07-11 | 2010-06-02 | 沃尼尔·朗伯有限责任公司 | 选择性cdk4抑制剂的羟乙基磺酸盐 |
| CN1946386A (zh) * | 2004-03-12 | 2007-04-11 | 埃吉斯药物工厂 | 作为镇痛药的德伦环烷和阿片类的组合 |
| PL2958916T3 (pl) | 2013-02-21 | 2019-01-31 | Pfizer Inc. | Stałe postacie selektywnego inhibitora CDK4/6 |
| US20170240543A1 (en) * | 2014-08-14 | 2017-08-24 | Sun Pharmaceutical Industries Limited | Crystalline forms of palbociclib |
| CN104327078A (zh) * | 2014-10-24 | 2015-02-04 | 上海博氏医药科技有限公司 | Cdk-4/6抑制剂的新合成方法 |
| WO2016066420A1 (en) | 2014-10-29 | 2016-05-06 | Sandoz Ag | Crystalline forms of palbociclib monohydrochloride |
| US9994579B2 (en) | 2014-12-12 | 2018-06-12 | Crystal Pharmatech Co., Ltd. | Salt of pyrrolo[2,3-D]pyrimidine compound and novel polymorph of salt |
| CZ201589A3 (cs) * | 2015-02-11 | 2016-08-24 | Zentiva, K.S. | Pevné formy soli Palbociclibu |
-
2015
- 2015-10-28 HU HU1500506A patent/HU230962B1/hu unknown
-
2016
- 2016-10-26 LT LTEP16859141.0T patent/LT3368527T/lt unknown
- 2016-10-26 HU HUE16859141A patent/HUE054908T2/hu unknown
- 2016-10-26 EP EP16859141.0A patent/EP3368527B1/en active Active
- 2016-10-26 PL PL16859141T patent/PL3368527T3/pl unknown
- 2016-10-26 EA EA201890963A patent/EA035346B1/ru unknown
- 2016-10-26 WO PCT/HU2016/050050 patent/WO2017072543A1/en active Application Filing
- 2016-10-26 ES ES16859141T patent/ES2875402T3/es active Active
- 2016-10-26 UA UAA201805312A patent/UA123218C2/uk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL3368527T3 (pl) | 2021-11-02 |
| EP3368527A1 (en) | 2018-09-05 |
| EA035346B1 (ru) | 2020-05-29 |
| HU230962B1 (hu) | 2019-06-28 |
| ES2875402T3 (es) | 2021-11-10 |
| EP3368527A4 (en) | 2019-04-10 |
| WO2017072543A1 (en) | 2017-05-04 |
| HUE054908T2 (hu) | 2021-10-28 |
| UA123218C2 (uk) | 2021-03-03 |
| LT3368527T (lt) | 2021-08-10 |
| HUP1500506A2 (en) | 2017-07-28 |
| EP3368527B1 (en) | 2021-04-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1122730T1 (el) | 1,2,4-τριαζολες ως διαμορφωτες πυρηνικης μεταφορας και χρησεις αυτων | |
| PH12018501807A1 (en) | Pyrazolopyrrolidine derivatives and their use in the treatment of diseas | |
| BR112017003054A2 (pt) | compostos de aminopirimidinila como inibidores de jak | |
| EA201790389A1 (ru) | Пирролопиримидиновые соединения, используемые в качестве агониста tlr7 | |
| EA201791256A1 (ru) | Производные хиназолина, применяемые для лечения вич | |
| EA201690357A1 (ru) | Лекарственные формы с замедленным высвобождением для ингибитора jak1 | |
| MX2015016344A (es) | Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades. | |
| EA202090860A1 (ru) | Аналоги тиадиазола и способы лечения состояний, связанных с дефицитом smn | |
| EA201891063A1 (ru) | Производные дигидроимидазопиразинона, применимые в лечении рака | |
| SG10201805628TA (en) | Deuterated heterocyclic compounds and their use as imaging agents | |
| EA201692341A1 (ru) | Соли дазатиниба | |
| EA201892119A1 (ru) | Лекарственный препарат, полученный путем комбинирования агониста fxr и arb | |
| EA201790726A1 (ru) | Фармацевтическая композиция для лечения язвенного колита | |
| CY1124251T1 (el) | Παραγωγα καρβοξαμιδιου | |
| PH12018500377A1 (en) | Novel annelated benzamides | |
| SA518390920B1 (ar) | مركبات فينوكسي أسيتاميد معالجة بإضافة حلقة | |
| EA201990765A1 (ru) | Азаиндазольные соединения для применения при повреждениях сухожилий и/или связок | |
| EA201692298A1 (ru) | Производные карбоксамидов | |
| EA201790687A1 (ru) | Хинолинкарбоксамиды для применения в лечении множественной миеломы | |
| EA201792264A1 (ru) | Способы лечения воспалительных заболеваний | |
| EA201700356A1 (ru) | Новые циклопропанбензофуранилпиридопиразиндионы | |
| EA201691673A1 (ru) | Замещенные циклопентаны, тетрагидрофураны и пирролидины как антагонисты орексиновых рецепторов | |
| EA201990766A1 (ru) | Индазольные соединения для применения при повреждениях сухожилий и/или связок | |
| EA201890963A1 (ru) | Соли палбоциклиба | |
| EA201692090A1 (ru) | Полициклические активаторы herg |