EA201692341A1 - Соли дазатиниба - Google Patents
Соли дазатинибаInfo
- Publication number
- EA201692341A1 EA201692341A1 EA201692341A EA201692341A EA201692341A1 EA 201692341 A1 EA201692341 A1 EA 201692341A1 EA 201692341 A EA201692341 A EA 201692341A EA 201692341 A EA201692341 A EA 201692341A EA 201692341 A1 EA201692341 A1 EA 201692341A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dasatinib
- salt
- acid
- salts
- toluenesulfonic acid
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 8
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical class C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 abstract 9
- 239000002067 L01XE06 - Dasatinib Substances 0.000 abstract 9
- 229960002448 dasatinib Drugs 0.000 abstract 9
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 8
- 150000004922 Dasatinib derivatives Chemical class 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000004122 cyclic group Chemical group 0.000 abstract 3
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000008043 acidic salts Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- -1 dihydrate salt Chemical class 0.000 abstract 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение относится к нормальным или кислым солям дазатиниба и их гидратным и сольватным формам. Более конкретно, изобретение относится к соли дазатиниба и цикламовой кислоты, соли дазатиниба и цикламовой кислоты (1:1) формы I, соли дазатиниба и цикламовой кислоты (1:1) формы II, соли дазатиниба и бромоводорода (1:2), соли дазатиниба и метансульфоновой кислоты (1:2), дигидратной соли дазатиниба и п-толуолсульфоновой кислоты (1:1), безводной соли дазатиниба и п-толуолсульфоновой кислоты (1:1) формы I, безводной соли дазатиниба и п-толуолсульфоновой кислоты (1:1) формы II, метанол сольвату соли дазатиниба и п-толуолсульфоновой кислоты (1:1). Кроме того, изобретение относится к способу получения солей дазатиниба, содержащим их фармацевтическим композициям и применению солей дазатиниба для лечения рака.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU1400264A HU231013B1 (hu) | 2014-05-26 | 2014-05-26 | Dasatinib sók |
PCT/HU2015/000049 WO2015181573A1 (en) | 2014-05-26 | 2015-05-26 | Dasatinib salts |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201692341A1 true EA201692341A1 (ru) | 2017-05-31 |
EA030142B1 EA030142B1 (ru) | 2018-06-29 |
Family
ID=89991500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201692341A EA030142B1 (ru) | 2014-05-26 | 2015-05-26 | Соли дазатиниба |
Country Status (9)
Country | Link |
---|---|
US (1) | US10023566B2 (ru) |
EP (1) | EP3148991A1 (ru) |
CN (1) | CN106661015B (ru) |
BR (1) | BR112016027685A2 (ru) |
EA (1) | EA030142B1 (ru) |
GE (1) | GEP20186923B (ru) |
HU (1) | HU231013B1 (ru) |
MX (1) | MX369642B (ru) |
WO (1) | WO2015181573A1 (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107501305B (zh) * | 2017-09-26 | 2019-04-05 | 玉林师范学院 | 一种达沙替尼-铜(ii)配合物及其合成方法和应用 |
WO2019209908A1 (en) | 2018-04-25 | 2019-10-31 | Johnson Matthey Public Limited Company | Crystalline forms of dasatinib |
WO2019241504A1 (en) | 2018-06-15 | 2019-12-19 | Handa Pharmaceuticals, Llc | Kinase inhibitor salts and compositions thereof |
GB201913124D0 (en) | 2019-09-11 | 2019-10-23 | Seald As | Compositions and methods for treatment of cholangiocarcinoma |
GB201913122D0 (en) | 2019-09-11 | 2019-10-23 | Seald As | Compositions and methods for treatment of cholangiocarcinoma |
GB201913123D0 (en) | 2019-09-11 | 2019-10-23 | Seald As | Compositions and methods for treatment of cholangiocarcinoma |
GB201913121D0 (en) | 2019-09-11 | 2019-10-23 | Seald As | Compositions and methods for treatment of cholangiocarcinoma |
IL294928A (en) | 2020-01-24 | 2022-09-01 | Nanocopoeia Llc | Amorphous solid dispersions of dasatinib and uses thereof |
IL295007A (en) | 2020-01-31 | 2022-09-01 | Nanocopoeia Llc | Amorphous nilotinib microparticles and uses thereof |
WO2021222739A1 (en) | 2020-04-30 | 2021-11-04 | Nanocopoeia, Llc | Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib |
US11980619B2 (en) | 2021-07-28 | 2024-05-14 | Nanocopoeia, Llc | Pharmaceutical compositions and crushable tablets including amorphous solid dispersions of dasatinib and uses |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL144910A0 (en) | 1999-04-15 | 2002-06-30 | Bristol Myers Squibb Co | Cyclic compounds and pharmaceutical compositions containing the same |
TWI338004B (en) | 2004-02-06 | 2011-03-01 | Bristol Myers Squibb Co | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
US20070105867A1 (en) | 2005-09-21 | 2007-05-10 | Bristol-Myers Squibb Company | Oral administration of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-1,3-thiazole-5-carboxamide and salts thereof |
-
2014
- 2014-05-26 HU HU1400264A patent/HU231013B1/hu unknown
-
2015
- 2015-05-26 GE GEAP201514361A patent/GEP20186923B/en unknown
- 2015-05-26 EA EA201692341A patent/EA030142B1/ru not_active IP Right Cessation
- 2015-05-26 MX MX2016015420A patent/MX369642B/es active IP Right Grant
- 2015-05-26 WO PCT/HU2015/000049 patent/WO2015181573A1/en active Application Filing
- 2015-05-26 CN CN201580034841.7A patent/CN106661015B/zh not_active Expired - Fee Related
- 2015-05-26 BR BR112016027685A patent/BR112016027685A2/pt not_active Application Discontinuation
- 2015-05-26 EP EP15731652.2A patent/EP3148991A1/en not_active Withdrawn
- 2015-05-26 US US15/314,255 patent/US10023566B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US10023566B2 (en) | 2018-07-17 |
US20170183334A1 (en) | 2017-06-29 |
HU231013B1 (hu) | 2019-11-28 |
EA030142B1 (ru) | 2018-06-29 |
MX369642B (es) | 2019-11-15 |
WO2015181573A1 (en) | 2015-12-03 |
EP3148991A1 (en) | 2017-04-05 |
HUP1400264A2 (en) | 2015-11-30 |
BR112016027685A2 (pt) | 2019-01-08 |
CN106661015A (zh) | 2017-05-10 |
MX2016015420A (es) | 2017-07-04 |
GEP20186923B (en) | 2018-11-12 |
CN106661015B (zh) | 2020-04-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM RU |