EA201890695A1 - Новые пиразолилзамещенные гетероарилы и их применение в качестве лекарственных средств - Google Patents

Новые пиразолилзамещенные гетероарилы и их применение в качестве лекарственных средств

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EA201890695A1
EA201890695A1 EA201890695A EA201890695A EA201890695A1 EA 201890695 A1 EA201890695 A1 EA 201890695A1 EA 201890695 A EA201890695 A EA 201890695A EA 201890695 A EA201890695 A EA 201890695A EA 201890695 A1 EA201890695 A1 EA 201890695A1
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Eurasian Patent Office
Prior art keywords
heteroaryles
medicines
application
pyrazolyl substituted
new
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EA201890695A
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English (en)
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EA033978B1 (ru
Inventor
Маттиас Хоффманн
Георг Даманн
Кристиан Гнамм
Дэниел Фэндрик
Джон Скотт
Клайв Маккарти
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Бёрингер Ингельхайм Интернациональ Гмбх
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Publication of EA201890695A1 publication Critical patent/EA201890695A1/ru
Publication of EA033978B1 publication Critical patent/EA033978B1/ru

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Изобретение относится к новым замещенным гетероарилам формулы 1или формулы 1'в которой A означает или N, или CH, Rвыбирают из группы, включающей -C-алкил, -C-галоалкил, F, Br, Cl, Y выбирают из -O- или -CH- и Rопределен как в п.1; к их фармацевтически приемлемым солям и к применению этих указанных выше соединений для лечения заболеваний, таких как астма, ХОЗЛ, аллергический ринит, аллергический дерматит, эритематозная волчанка, волчаночный нефрит и ревматоидный артрит.
EA201890695A 2015-09-11 2016-09-02 Пиразолилзамещенные гетероарилы и их применение в качестве лекарственных средств EA033978B1 (ru)

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US201562217269P 2015-09-11 2015-09-11
PCT/EP2016/070729 WO2017042100A1 (en) 2015-09-11 2016-09-02 Pyrazolyl-substituted heteroaryls and their use as medicaments

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EA033978B1 EA033978B1 (ru) 2019-12-16

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EP (1) EP3347353B1 (ru)
JP (1) JP6868011B2 (ru)
KR (1) KR20180051624A (ru)
CN (1) CN108026080B (ru)
AR (1) AR105991A1 (ru)
AU (1) AU2016320297B2 (ru)
CA (1) CA2998250A1 (ru)
CL (1) CL2018000400A1 (ru)
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HU (1) HUE046920T2 (ru)
IL (1) IL257392B (ru)
MX (1) MX2018003008A (ru)
PH (1) PH12018500533A1 (ru)
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
EP3099677A4 (en) 2014-01-31 2017-07-26 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
JP6416275B2 (ja) 2014-03-19 2018-10-31 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ヘテロアリールｓｙｋ阻害剤
EA033978B1 (ru) 2015-09-11 2019-12-16 Бёрингер Ингельхайм Интернациональ Гмбх Пиразолилзамещенные гетероарилы и их применение в качестве лекарственных средств
WO2017044792A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Acetamide thienotriazoldiazepines and uses thereof
BR112018004618A2 (pt) 2015-09-11 2018-09-25 Dana-Farber Cancer Institute, Inc. ciano tienotriazoldiazepinas e usos das mesmas
SG10201913450PA (en) 2015-11-25 2020-03-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof
TW201927769A (zh) * 2017-12-18 2019-07-16 德商歌林達有限公司 經取代之吡咯啶醯胺ｉｉ
US11633399B2 (en) 2018-12-25 2023-04-25 Sol-Gel Technologies Ltd. Treatment of skin disorders with compositions comprising an EGFR inhibitor
JP2023550591A (ja) 2020-11-02 2023-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ＥＧＦＲ阻害薬としての置換１Ｈ－ピラゾロ［４，３－ｃ］及び誘導体
CN115197115A (zh) * 2022-08-25 2022-10-18 成都金博汇康医药科技有限公司 一种手性5-氧代吡咯烷-3-甲酸的制备方法与应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001302667A (ja) 2000-04-28 2001-10-31 Bayer Ag イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
WO2006044528A1 (en) * 2004-10-15 2006-04-27 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
JP5055263B2 (ja) * 2005-03-30 2012-10-24 ダエウン ファーマシューティカル カンパニー リミテッド 抗真菌性トリアゾール誘導体
JP5754568B2 (ja) 2008-08-05 2015-07-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ４−ジメチルアミノ−フェニルで置換されているナフチリジン、及び医薬としてのその使用
EP2324022A1 (de) 2008-08-05 2011-05-25 Boehringer Ingelheim International GmbH Substituierte naphthyridine und ihre verwendung als arzneimittel
TWI453207B (zh) 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
CN102307581B (zh) * 2008-12-08 2016-08-17 吉利德康涅狄格股份有限公司 咪唑并哌嗪syk抑制剂
NZ600857A (en) 2010-01-29 2014-06-27 Boehringer Ingelheim Int Substituted naphthyridines and their use as syk kinase inhibitors
EP2683716A1 (en) 2011-03-11 2014-01-15 Glaxo Group Limited Pyrido[3,4-b]pyrazine derivatives as syk inhibitors
US8921383B2 (en) 2011-03-28 2014-12-30 Hoffmann-La Roche Inc. Thiazolopyrimidine compounds
CA2843022C (en) 2011-07-26 2019-09-24 Boehringer Ingelheim International Gmbh Substituted quinolines and their use as medicaments
WO2013047813A1 (ja) * 2011-09-30 2013-04-04 大鵬薬品工業株式会社 １，２，４－トリアジン－６－カルボキサミド誘導体
RU2014151009A (ru) 2012-06-07 2016-08-10 Ф. Хоффманн-Ля Рош Аг Пиразолопиримидоновые и пиразолопиридоновые ингибиторы танкиразы
WO2014100113A2 (en) 2012-12-18 2014-06-26 Hulow, Llc Syk kinase inhibitors as treatment for malaria
AU2014296184B2 (en) 2013-07-31 2017-04-27 Gilead Sciences, Inc. Syk inhibitors
US10160753B2 (en) * 2014-01-10 2018-12-25 Aurigene Discovery Technologies Limited Indazole compounds as IRAK4 inhibitors
JP6416275B2 (ja) * 2014-03-19 2018-10-31 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ヘテロアリールｓｙｋ阻害剤
TW201617074A (zh) * 2014-07-14 2016-05-16 吉李德科學股份有限公司 Ｓｙｋ（脾酪胺酸激酶）抑制劑
EA033978B1 (ru) 2015-09-11 2019-12-16 Бёрингер Ингельхайм Интернациональ Гмбх Пиразолилзамещенные гетероарилы и их применение в качестве лекарственных средств

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US9845314B2 (en) 2017-12-19
US20180148433A1 (en) 2018-05-31
CN108026080A (zh) 2018-05-11
HUE046920T2 (hu) 2020-03-30
CL2018000400A1 (es) 2018-07-13
CA2998250A1 (en) 2017-03-16
US20170073333A1 (en) 2017-03-16
PL3347353T3 (pl) 2020-01-31
KR20180051624A (ko) 2018-05-16
AU2016320297A1 (en) 2018-02-08
WO2017042100A1 (en) 2017-03-16
MX2018003008A (es) 2018-04-11
JP2018529679A (ja) 2018-10-11
EA033978B1 (ru) 2019-12-16
EP3347353A1 (en) 2018-07-18
ES2745284T3 (es) 2020-02-28
PH12018500533A1 (en) 2018-09-10
US10155751B2 (en) 2018-12-18
DK3347353T3 (da) 2019-10-21
CN108026080B (zh) 2021-06-11
AR105991A1 (es) 2017-11-29
TW201720799A (zh) 2017-06-16
JP6868011B2 (ja) 2021-05-12
IL257392A (en) 2018-04-30
AU2016320297B2 (en) 2020-08-27
IL257392B (en) 2020-05-31
EP3347353B1 (en) 2019-07-17

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