EA201890302A1 - CHEMICAL ANTIGEN RECEPTORS BASED ON SINGLE-DOMAIN ANTIBODIES AND METHODS OF THEIR APPLICATION - Google Patents
CHEMICAL ANTIGEN RECEPTORS BASED ON SINGLE-DOMAIN ANTIBODIES AND METHODS OF THEIR APPLICATIONInfo
- Publication number
- EA201890302A1 EA201890302A1 EA201890302A EA201890302A EA201890302A1 EA 201890302 A1 EA201890302 A1 EA 201890302A1 EA 201890302 A EA201890302 A EA 201890302A EA 201890302 A EA201890302 A EA 201890302A EA 201890302 A1 EA201890302 A1 EA 201890302A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antigen receptors
- methods
- domain antibodies
- application
- receptors based
- Prior art date
Links
- 108010003723 Single-Domain Antibodies Proteins 0.000 title abstract 3
- 102000006306 Antigen Receptors Human genes 0.000 title 1
- 108010083359 Antigen Receptors Proteins 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000012642 immune effector Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Abstract
В данном изобретении предложены однодоменные антитела и химерные рецепторы антигенов, содержащие один или большее количество антигенсвязывающих доменов, каждый из которых содержит однодоменное антитело. Дополнительно предложены сконструированные иммунные эффекторные клетки (такие как Т-клетки), содержащие химерные рецепторы антигенов. Также предложены фармацевтические композиции, наборы и способы лечения рака.The present invention provides single domain antibodies and chimeric antigen receptors containing one or more antigen-binding domains, each of which contains a single domain antibody. Additionally, designed immune effector cells (such as T cells) containing chimeric antigen receptors have been proposed. Also proposed pharmaceutical compositions, kits and methods for treating cancer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510490002 | 2015-08-11 | ||
CN201510733585.2A CN105384825B (en) | 2015-08-11 | 2015-11-02 | A kind of bispecific chimeric antigen receptor and its application based on single domain antibody |
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