EA201791447A1 - Способы осаждения полимера и дезактивированного металлоорганического катализатора в реакции олигомеризации олефина - Google Patents

Способы осаждения полимера и дезактивированного металлоорганического катализатора в реакции олигомеризации олефина

Info

Publication number
EA201791447A1
EA201791447A1 EA201791447A EA201791447A EA201791447A1 EA 201791447 A1 EA201791447 A1 EA 201791447A1 EA 201791447 A EA201791447 A EA 201791447A EA 201791447 A EA201791447 A EA 201791447A EA 201791447 A1 EA201791447 A1 EA 201791447A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polymer
effluent
organometallic catalyst
deposition
olefin
Prior art date
Application number
EA201791447A
Other languages
English (en)
Other versions
EA033757B1 (ru
Inventor
Тимур Михайлович ЗИЛЬБЕРШТЕЙН
Original Assignee
Публичное акционерное общество "СИБУР Холдинг"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Публичное акционерное общество "СИБУР Холдинг" filed Critical Публичное акционерное общество "СИБУР Холдинг"
Publication of EA201791447A1 publication Critical patent/EA201791447A1/ru
Publication of EA033757B1 publication Critical patent/EA033757B1/ru

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/06—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
    • B01J20/08—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04 comprising aluminium oxide or hydroxide; comprising bauxite
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B01J20/28007—Sorbent size or size distribution, e.g. particle size with size in the range 1-100 nanometers, e.g. nanosized particles, nanofibers, nanotubes, nanowires or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3042—Use of binding agents; addition of materials ameliorating the mechanical properties of the produced sorbent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
    • B01J31/14—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
    • B01J31/143—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron of aluminium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1805—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing nitrogen
    • B01J31/181—Cyclic ligands, including e.g. non-condensed polycyclic ligands, comprising at least one complexing nitrogen atom as ring member, e.g. pyridine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons
    • C07C11/02—Alkenes
    • C07C11/04—Ethylene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons
    • C07C11/02—Alkenes
    • C07C11/107—Alkenes with six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2/00—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms
    • C07C2/02—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons
    • C07C2/04—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons by oligomerisation of well-defined unsaturated hydrocarbons without ring formation
    • C07C2/06—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons by oligomerisation of well-defined unsaturated hydrocarbons without ring formation of alkenes, i.e. acyclic hydrocarbons having only one carbon-to-carbon double bond
    • C07C2/08—Catalytic processes
    • C07C2/10—Catalytic processes with metal oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2/00—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms
    • C07C2/02—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons
    • C07C2/04—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons by oligomerisation of well-defined unsaturated hydrocarbons without ring formation
    • C07C2/06—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons by oligomerisation of well-defined unsaturated hydrocarbons without ring formation of alkenes, i.e. acyclic hydrocarbons having only one carbon-to-carbon double bond
    • C07C2/08—Catalytic processes
    • C07C2/26—Catalytic processes with hydrides or organic compounds
    • C07C2/30—Catalytic processes with hydrides or organic compounds containing metal-to-carbon bond; Metal hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2/00—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms
    • C07C2/02—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons
    • C07C2/04—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons by oligomerisation of well-defined unsaturated hydrocarbons without ring formation
    • C07C2/06—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons by oligomerisation of well-defined unsaturated hydrocarbons without ring formation of alkenes, i.e. acyclic hydrocarbons having only one carbon-to-carbon double bond
    • C07C2/08—Catalytic processes
    • C07C2/26—Catalytic processes with hydrides or organic compounds
    • C07C2/32—Catalytic processes with hydrides or organic compounds as complexes, e.g. acetyl-acetonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/12—Purification; Separation; Use of additives by adsorption, i.e. purification or separation of hydrocarbons with the aid of solids, e.g. with ion-exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/20—Olefin oligomerisation or telomerisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/60—Complexes comprising metals of Group VI (VIA or VIB) as the central metal
    • B01J2531/62—Chromium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2531/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • C07C2531/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • C07C2531/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2531/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • C07C2531/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • C07C2531/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
    • C07C2531/14—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2531/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • C07C2531/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • C07C2531/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Water Supply & Treatment (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nanotechnology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Catalysts (AREA)

Abstract

Предлагается способ осаждения полимера и дезактивированного металлоорганического катализатора в реакции олигомеризации олефина. Способ включает получение выходящего потока из реакции олигомеризации олефина. Выходящий поток может включать полимер и металлоорганический катализатор. Способ может дополнительно включать введение частиц сорбента в выходящий поток. Частицы сорбента могут включать дезактивирующий агент. Дезактивирующий агент может представлять собой воду, спирт, амин, аминоспирт или соответствующее сочетание. По меньшей мере приблизительно 10% частиц сорбента могут иметь размер частицы в диапазоне от 10 до 60 мкм. Способ может дополнительно включать охлаждение выходящего потока, в результате которого происходит осаждение полимера и дезактивированного металлоорганического катализатора из выходящего потока, и получается осадок, который включает сорбент, полимер и дезактивированный катализатор.
EA201791447A 2014-12-23 2014-12-23 Способ осаждения полимера и дезактивированного металлоорганического катализатора в реакции олигомеризации олефина EA033757B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2014/000972 WO2016105226A1 (en) 2014-12-23 2014-12-23 Methods of precipitating polymer and deactivated organometallic catalyst in an olefin oligomerization reaction

Publications (2)

Publication Number Publication Date
EA201791447A1 true EA201791447A1 (ru) 2017-10-31
EA033757B1 EA033757B1 (ru) 2019-11-22

Family

ID=53801140

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791447A EA033757B1 (ru) 2014-12-23 2014-12-23 Способ осаждения полимера и дезактивированного металлоорганического катализатора в реакции олигомеризации олефина

Country Status (11)

Country Link
US (1) US9975822B2 (ru)
EP (1) EP3237364B1 (ru)
JP (1) JP6666351B2 (ru)
KR (1) KR102113798B1 (ru)
CN (1) CN107207382B (ru)
CA (1) CA2971693C (ru)
DK (1) DK3237364T3 (ru)
EA (1) EA033757B1 (ru)
HR (1) HRP20190717T1 (ru)
MX (1) MX2017008374A (ru)
WO (1) WO2016105226A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017008376A (es) 2014-12-23 2018-04-11 Sibur Holding Public Joint Stock Co Metodos de preparacion de oligomeros de una olefina.
CN107207383B (zh) 2014-12-23 2021-02-26 公共型股份公司希布尔控股 制备烯烃的低聚物的方法
US10407358B2 (en) * 2017-03-14 2019-09-10 Saudi Arabian Oil Company Process for ethylene oligomerization to produce alpha-olefins
CN113508102A (zh) * 2019-02-22 2021-10-15 公共型股份公司希布尔控股 用于将烯烃低聚产物分离的方法(变型)
WO2020222168A1 (en) * 2019-05-01 2020-11-05 Chevron U.S.A. Inc. Base Oil Synthesis via Ionic Catalyst Oligomerization and Waterless Separation of the Oligomerization Catalyst
CN114787111B (zh) * 2020-09-07 2024-04-26 株式会社Lg化学 低聚物的制备方法
KR20220104418A (ko) * 2021-01-18 2022-07-26 주식회사 엘지화학 올리고머 제조방법
EP4194082A4 (en) * 2021-10-08 2024-03-06 Lg Chemical Ltd REACTION SOLUTION TRANSFER SYSTEM

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675463A (en) * 1986-02-05 1987-06-23 Exxon Chemical Patents Inc. Process for reducing fouling in higher olefin plants
DE4338415C1 (de) * 1993-11-10 1995-03-16 Linde Ag Verfahren zur Katalysatordesaktivierung bei der katalytisch beschleunigten Herstellung linearer Alpha-Olefine durch Oligomerisierung von Ethylen
CA2134503C (en) 1994-02-18 2001-04-10 Mark E. Lashier Olefin production
JPH11116614A (ja) * 1997-10-16 1999-04-27 Teijin Ltd α−オレフィン−環状オレフィン共重合体の製造方法
MXPA02005399A (es) 1999-12-29 2002-12-05 Phillips Petroleum Co Proceso para impedir la generacion de haluros de hidrogeno en un sistema de recuperacion de producto de oligomerizacion.
US7473815B2 (en) * 2003-11-12 2009-01-06 Crompton Corporation Process for removal of catalyst residues from poly-α-olefins
BRPI0907001B1 (pt) * 2008-01-30 2018-04-03 Linde Aktiengesellschaft Método para preparar alfa-olefinas lineares
RU2430116C1 (ru) 2010-01-29 2011-09-27 Закрытое Акционерное Общество "Сибур Холдинг" Способ полимеризации и сополимеризации олефиновых олигомеров
US20120165580A1 (en) * 2010-09-03 2012-06-28 Bahler Kenneth A Process For Production of Polyolefins
US9815915B2 (en) * 2010-09-03 2017-11-14 Exxonmobil Chemical Patents Inc. Production of liquid polyolefins
CA2723515C (en) * 2010-12-01 2018-05-15 Nova Chemicals Corporation Heat management in ethylene oligomerization
RU2471762C1 (ru) * 2011-06-22 2013-01-10 Открытое акционерное общество "СИБУР Холдинг" (ОАО "СИБУР Холдинг") Способ выделения продуктов олигомеризации олефинов и разложения остатков катализатора олигомеризации
CA2747501C (en) * 2011-07-26 2018-01-23 Nova Chemicals Corporation "bulk" ethylene oligomerization
WO2013109371A1 (en) 2012-01-17 2013-07-25 Exxonmobil Chemical Patents Inc. Process for production of liquid polyolefins
MX2017008376A (es) 2014-12-23 2018-04-11 Sibur Holding Public Joint Stock Co Metodos de preparacion de oligomeros de una olefina.
CN107207383B (zh) 2014-12-23 2021-02-26 公共型股份公司希布尔控股 制备烯烃的低聚物的方法

Also Published As

Publication number Publication date
CA2971693A1 (en) 2016-06-30
JP2018502088A (ja) 2018-01-25
HRP20190717T1 (hr) 2019-07-12
CN107207382B (zh) 2021-06-18
JP6666351B2 (ja) 2020-03-13
WO2016105226A1 (en) 2016-06-30
KR20170098282A (ko) 2017-08-29
EP3237364A1 (en) 2017-11-01
US9975822B2 (en) 2018-05-22
KR102113798B1 (ko) 2020-05-21
MX2017008374A (es) 2018-04-24
US20170349509A1 (en) 2017-12-07
CN107207382A (zh) 2017-09-26
CA2971693C (en) 2019-09-24
DK3237364T3 (da) 2019-05-13
EA033757B1 (ru) 2019-11-22
EP3237364B1 (en) 2019-03-06

Similar Documents

Publication Publication Date Title
EA201791447A1 (ru) Способы осаждения полимера и дезактивированного металлоорганического катализатора в реакции олигомеризации олефина
MX2019008550A (es) Metodos y sistemas para tratamiento de oxido de etileno.
EA201791136A1 (ru) Катализатор циглера-натта и его получение
MX2016016145A (es) Polimeros de nanocompuestos porosos para tratamiento de agua.
EA201991006A1 (ru) Полимерные системы для дисперсии частиц
JP2018520654A5 (ru)
CL2016002157A1 (es) Anticuerpos anti-cd38 para el tratamiento de leucemia linfoide aguda
BR112017003582A2 (pt) anticorpos, composições e usos
EA201692203A1 (ru) Соединения, ингибирующие tank-связывающую киназу
EA201691361A1 (ru) Антитела к lag-3 для лечения гематологических злокачественных опухолей
EA201500947A1 (ru) Устройство и способ электроосаждения нанослоистого покрытия
EA201692285A1 (ru) Ингибиторы ezh2 для лечения лимфомы
EA201890157A1 (ru) Способы лечения эпителиоидноклеточных опухолей
EA201790882A1 (ru) Способы и композиции для терапии рака печени
MX2020002745A (es) Inhibidores de rad51.
TR201900057T4 (tr) Selektif histon deasetilaz (HDAC) inhibitörleri olarak yeni azaindol deriveleri ve bunları içeren farmasötik bileşimler.
EA201790643A1 (ru) Способ и устройство для непрерывного нанесения нанослоистых металлических покрытий
ES2571737T3 (es) Procedimientos para la polimerización de olefinas con sales metálicas de carboxilato extraídas
EA201690958A1 (ru) Депрессанты для применения в способах разделения
EA201792096A2 (ru) РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА
EA201692550A1 (ru) Соединения, содержащие систему 1,1',2,5'-тетрагидроспиро[индол-3,2'-пиррол]-2,5'-диона в качестве ингибиторов белок-белкового взаимодействия p53-mdm2
MX2016006976A (es) Proceso para la preparacion de 5-fluoro-1h-pirazoles.
IN2015DN01490A (ru)
AR101290A1 (es) Inhibidores de aldosterona sintasa
WO2015138928A3 (en) Mixed mode ligands