EA201791313A1 - Агенты, связывающие суперсемейство рецепторов фактора некроза опухоли (tnfrsf), и их применения - Google Patents
Агенты, связывающие суперсемейство рецепторов фактора некроза опухоли (tnfrsf), и их примененияInfo
- Publication number
- EA201791313A1 EA201791313A1 EA201791313A EA201791313A EA201791313A1 EA 201791313 A1 EA201791313 A1 EA 201791313A1 EA 201791313 A EA201791313 A EA 201791313A EA 201791313 A EA201791313 A EA 201791313A EA 201791313 A1 EA201791313 A1 EA 201791313A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- agents
- polypeptides
- tnfrsf
- superfamily
- applications
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
Abstract
Описаны полипептиды и агенты, которые связывают белок рецептора суперсемейства TNF, особенно агенты, которые специфично связывают GITR, OX40 или CD40. Указанные полипептиды или агенты могут включать слитые полипептиды, особенно полипептиды, содержащие GITRL, OX40L или CD40L, и/или биспецифические агенты. Также описаны способы применения указанных полипептидов или агентов для индукции и/или усиления иммунного ответа, а также способы лечения заболеваний, таких как рак.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562111404P | 2015-02-03 | 2015-02-03 | |
US201562153272P | 2015-04-27 | 2015-04-27 | |
US201562154008P | 2015-04-28 | 2015-04-28 | |
US201562218956P | 2015-09-15 | 2015-09-15 | |
US201562259129P | 2015-11-24 | 2015-11-24 | |
PCT/US2016/016306 WO2016126781A1 (en) | 2015-02-03 | 2016-02-03 | Tnfrsf-binding agents and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201791313A1 true EA201791313A1 (ru) | 2018-02-28 |
Family
ID=56564627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201791313A EA201791313A1 (ru) | 2015-02-03 | 2016-02-03 | Агенты, связывающие суперсемейство рецепторов фактора некроза опухоли (tnfrsf), и их применения |
Country Status (18)
Country | Link |
---|---|
US (2) | US9724390B2 (ru) |
EP (1) | EP3253890A4 (ru) |
JP (1) | JP2018508233A (ru) |
KR (1) | KR20170108073A (ru) |
CN (2) | CN107406878A (ru) |
AU (1) | AU2016215394A1 (ru) |
BR (1) | BR112017016705A2 (ru) |
CA (1) | CA2975596A1 (ru) |
CO (1) | CO2017008047A2 (ru) |
EA (1) | EA201791313A1 (ru) |
HK (1) | HK1243741A1 (ru) |
IL (1) | IL253433A0 (ru) |
MA (1) | MA41460A (ru) |
MX (1) | MX2017009793A (ru) |
PH (1) | PH12017501372A1 (ru) |
SG (1) | SG11201706268XA (ru) |
TW (1) | TW201643184A (ru) |
WO (1) | WO2016126781A1 (ru) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3103875A1 (en) * | 2008-07-21 | 2016-12-14 | Apogenix AG | Tnfsf single chain molecules |
JP6461800B2 (ja) * | 2012-10-04 | 2019-01-30 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | ヒトモノクローナル抗pd−l1抗体および使用方法 |
CN105492017B (zh) | 2013-07-19 | 2020-12-01 | 弗拉芒区生物技术研究所 | 靶向经修饰的tnf家族成员 |
MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
CN107208099B (zh) | 2015-02-06 | 2022-05-13 | 热生物制品有限公司 | 共表达疫苗和共刺激分子的载体 |
MA42971A (fr) | 2015-03-13 | 2018-08-15 | Cytomx Therapeutics Inc | Anticorps anti-pdl1, anticorps anti-pld1 activables, et leurs procédés d'utilisation |
CA2991976A1 (en) | 2015-07-13 | 2017-01-19 | Cytomx Therapeutics, Inc. | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
CN116063566A (zh) | 2015-10-01 | 2023-05-05 | 热生物制品有限公司 | 作为异源嵌合蛋白邻接i型和ii型胞外结构域的组合物和方法 |
CA3004830A1 (en) | 2015-11-11 | 2017-05-18 | Opi Vi- Ip Holdco Llc | Composition and methods for anti-tnfr2 antibodies |
TW201741337A (zh) * | 2016-05-13 | 2017-12-01 | 麥迪紐有限責任公司 | CD40L-Fc融合多肽及其使用方法 |
CA3030636A1 (en) | 2016-07-14 | 2018-01-18 | Genmab A/S | Multispecific antibodies against cd40 and cd137 |
WO2018027025A1 (en) * | 2016-08-03 | 2018-02-08 | Oncomed Pharmaceuticals, Inc. | Cd40-binding agents and uses thereof |
US11666649B2 (en) | 2016-10-11 | 2023-06-06 | University Of Miami | Vectors and vaccine cells for immunity against Zika virus |
MA46529A (fr) | 2016-10-11 | 2019-08-21 | Agenus Inc | Anticorps anti-lag-3 et leurs procédés d'utilisation |
CA3052523A1 (en) | 2017-02-06 | 2018-08-09 | Orionis Biosciences Nv | Targeted chimeric proteins and uses thereof |
US20200291089A1 (en) * | 2017-02-16 | 2020-09-17 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
US11192933B2 (en) * | 2017-02-27 | 2021-12-07 | Shattuck Labs, Inc. | VSIG8-based chimeric proteins |
MX2019009812A (es) | 2017-02-27 | 2019-10-14 | Shattuck Labs Inc | Proteinas quimericas basadas en tigit y light. |
US11267856B2 (en) | 2017-02-27 | 2022-03-08 | Shattuck Labs, Inc. | CSF1R-CD40L chimeric proteins |
WO2018160572A1 (en) * | 2017-02-28 | 2018-09-07 | Oncomed Pharmaceuticals, Inc. | Methods for treatment of cancer comprising gitr-binding agents |
WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
CA3058938A1 (en) | 2017-04-04 | 2018-10-11 | Heat Biologics, Inc. | Intratumoral vaccination |
US11518810B2 (en) | 2017-05-08 | 2022-12-06 | Shanghai Jmt-Bio Technology Co., Ltd. | Bispecific recombinant protein and use thereof |
KR20200006115A (ko) | 2017-05-16 | 2020-01-17 | 브리스톨-마이어스 스큅 컴퍼니 | 항-gitr 효능제 항체에 의한 암의 치료 |
WO2018222949A1 (en) | 2017-06-01 | 2018-12-06 | Cytomx Therapeutics, Inc. | Activatable anti-pdl1 antibodies, and methods of use thereof |
KR102371420B1 (ko) * | 2017-06-27 | 2022-03-08 | (주)아모레퍼시픽 | Tnfsf14 단백질을 포함하는 미백용 조성물 |
WO2019032945A1 (en) * | 2017-08-10 | 2019-02-14 | Oncomed Pharmaceuticals, Inc. | CD40 BINDING AGENT AND USES THEREOF |
US20210079106A1 (en) * | 2017-12-28 | 2021-03-18 | Julius-Maximilians-Universität Würzburg | TUMOR NECROSIS FACTOR (TNF) RECEPTOR SUPERFAMILY (TNFRSF) RECEPTOR-ACTIVATING ANTIBODY FUSION PROTEINS WITH FCgR-INDEPENDENT AGONISTIC ACTIVITY (TNFRSF RECEPTOR-ACTIVATING ANTIBODY FUSION PROTEINS WITH FCgR-INDEPENDENT AGONISTIC ACTIVITY; TRAAFFIAA) |
JP7332627B2 (ja) | 2018-04-25 | 2023-08-23 | プロメテウス バイオサイエンシーズ,インク. | 最適化された抗tl1a抗体 |
WO2019237383A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | 用于人 tnfsf18 基因编辑的修饰载体、其制备方法及应用 |
US10780121B2 (en) | 2018-08-29 | 2020-09-22 | Shattuck Labs, Inc. | FLT3L-based chimeric proteins |
CN111454364B (zh) * | 2019-03-04 | 2021-03-02 | 北京天广实生物技术股份有限公司 | 结合cd40的抗体及其用途 |
MX2022004942A (es) | 2019-10-24 | 2022-07-27 | Prometheus Biosciences Inc | Anticuerpos humanizados contra el ligando 1a de tipo tnf (tl1a) y usos de los mismos. |
CN115836084A (zh) * | 2020-05-15 | 2023-03-21 | 阿珀吉尼科斯股份公司 | 多特异性免疫调节剂 |
WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
US20240166720A1 (en) * | 2021-03-12 | 2024-05-23 | Janssen Biotech, Inc. | Bioengineered immunomodulatory fusion protein compositions |
WO2023088876A1 (en) * | 2021-11-16 | 2023-05-25 | Apogenix Ag | Multi-specific immune modulators |
WO2024107749A1 (en) * | 2022-11-16 | 2024-05-23 | Attralus, Inc. | Fusion proteins that bind amyloid and the transferrin receptor and uses thereof |
Family Cites Families (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0325224B1 (en) | 1988-01-22 | 1996-07-31 | ZymoGenetics, Inc. | Methods of producing secreted receptor analogs |
US5962406A (en) | 1991-10-25 | 1999-10-05 | Immunex Corporation | Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same |
US5716805A (en) | 1991-10-25 | 1998-02-10 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
DE69332981T2 (de) | 1992-10-23 | 2004-05-19 | Immunex Corp., Seattle | Methoden zur herstellung löslicher, oligomerer proteine |
US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
US6242566B1 (en) | 1994-02-10 | 2001-06-05 | Board Of Trustees Of The Leland Stanford Junior University | Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells |
JP2000516474A (ja) | 1996-08-16 | 2000-12-12 | ヒューマン ジノーム サイエンシーズ,インコーポレイテッド | ヒトエンドカインα |
US5998171A (en) | 1996-08-16 | 1999-12-07 | Human Genome Sciences, Inc. | Polynucleotides encoding human endokine alpha |
US6406867B1 (en) | 1996-08-16 | 2002-06-18 | Human Genome Sciences, Inc. | Antibody to human endokine alpha and methods of use |
JP4485049B2 (ja) | 1997-11-18 | 2010-06-16 | ジェネンテック, インコーポレイテッド | Dna19355ポリペプチドという腫瘍壊死因子相同体 |
DE69939526D1 (de) | 1998-02-24 | 2008-10-23 | Sisters Of Providence In Orego | Zusammensetzungen, die entweder ein ox-40-rezeptor-bindemittel oder eine für ein solches bindemittel kodierende nukleicsäuresequenz enthalten, und verfahren zur verbesserung der antigenspezifischen immunantwort |
US6312700B1 (en) | 1998-02-24 | 2001-11-06 | Andrew D. Weinberg | Method for enhancing an antigen specific immune response with OX-40L |
US7300774B1 (en) | 1999-12-09 | 2007-11-27 | The Regents Of The University Of California | Multimeric fusion proteins of the TNF superfamily ligands |
JP2002537769A (ja) | 1999-02-26 | 2002-11-12 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | ヒトエンドカインαおよび使用方法 |
IL147442A0 (en) | 1999-07-12 | 2002-08-14 | Genentech Inc | Promotion or inhibition of angiogenesis and cardiovscularization by tumor necrosis factor ligand/receptor homologs |
US20080050809A1 (en) | 1999-09-28 | 2008-02-28 | Alejandro Abuin | Novel human kinases and polynucleotides encoding the same |
AR025984A1 (es) | 1999-10-07 | 2002-12-26 | Maxygen Aps | Polipeptidos oligomericos de cadena simple |
EP1234031B2 (en) | 1999-11-30 | 2021-11-24 | Mayo Foundation For Medical Education And Research | B7-h1, a novel immunoregulatory molecule |
DE19963859A1 (de) | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
WO2002086083A2 (en) | 2001-04-20 | 2002-10-31 | Mayo Foundation For Medical Education And Research | Methods of enhancing cell responsiveness |
DE10122140A1 (de) | 2001-05-08 | 2002-11-28 | Apotech Res & Dev Ltd | Rekombinante Fusionsproteine und deren Trimere |
US20030133936A1 (en) | 2001-07-12 | 2003-07-17 | Byrne Michael Chapman | CD25markers and uses thereof |
US7087225B2 (en) | 2001-08-16 | 2006-08-08 | Human Genome Sciences, Inc. | Methods and compositions for treating metabolic bone diseases relating to human endokine alpha |
CA2466279A1 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
US7736657B2 (en) | 2002-02-10 | 2010-06-15 | Apoxis S.A. | Fusion constructs containing active sections on TNF ligands |
EP1575480A4 (en) | 2002-02-22 | 2008-08-06 | Genentech Inc | COMPOSITIONS AND METHODS FOR TREATING DISEASES RELATED TO THE IMMUNE SYSTEM |
US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
IL164376A0 (en) | 2002-04-03 | 2005-12-18 | Applied Research Systems | Ox4or binding agents, their preparation and pharmaceutical compositions containing them |
US20070015271A1 (en) | 2002-04-04 | 2007-01-18 | Rosen Craig A | Human secreted proteins |
ATE481985T1 (de) | 2002-07-03 | 2010-10-15 | Ono Pharmaceutical Co | Immunpotenzierende zusammensetzungen |
ATE493433T1 (de) | 2002-09-11 | 2011-01-15 | Genentech Inc | Neue zusammensetzung und verfahren zur behandlung von immunerkrankungen |
EP2311867A1 (en) | 2002-10-29 | 2011-04-20 | Anaphore, Inc. | Trimeric binding proteins for trimeric cytokines |
EP1462114A1 (en) | 2003-03-28 | 2004-09-29 | Universiteit Utrecht Holding B.V. | Methods and means to suppress symptons of an allergic disease by inhibiting the glucocorticoid-induced tumor necrosis factor receptor (GRIT or TNFRSF18) |
US7618632B2 (en) | 2003-05-23 | 2009-11-17 | Wyeth | Method of treating or ameliorating an immune cell associated pathology using GITR ligand antibodies |
EP1660126A1 (en) | 2003-07-11 | 2006-05-31 | Schering Corporation | Agonists or antagonists of the clucocorticoid-induced tumour necrosis factor receptor (gitr) or its ligand for the treatment of immune disorders, infections and cancer |
US7268116B2 (en) | 2003-10-02 | 2007-09-11 | Genhunter Corp. | Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins |
DE102004014983A1 (de) | 2004-03-26 | 2005-10-20 | Univ Stuttgart | Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung |
GB0409799D0 (en) | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
CA2943949C (en) | 2004-10-06 | 2020-03-31 | Mayo Foundation For Medical Education And Research | B7-h1 and methods of diagnosis, prognosis, and treatment of cancer |
AU2005302459A1 (en) | 2004-10-29 | 2006-05-11 | University Of Southern California | Combination cancer immunotherapy with co-stimulatory molecules |
PT2343320T (pt) | 2005-03-25 | 2018-01-23 | Gitr Inc | Anticorpos anti-gitr e as suas utilizações |
EP2650020B1 (en) | 2005-05-06 | 2016-08-24 | Providence Health & Services - Oregon | Trimeric OX40-immunoglobulin fusion protein and methods of use |
EP3683230A1 (en) | 2005-05-12 | 2020-07-22 | ZymoGenetics, Inc. | Compositions and methods for modulating immune responses |
LT2397156T (lt) | 2005-06-08 | 2017-02-27 | Dana-Farber Cancer Institute, Inc. | Būdai ir kompozicijos, skirti nuolatinių infekcijų ir vėžio gydymui inhibuojant užprogramuotos ląstelės mirties-1 (pd-1) kelią |
KR101607288B1 (ko) | 2005-07-01 | 2016-04-05 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
US20080286286A1 (en) | 2006-01-13 | 2008-11-20 | Board Of Regents, The University Of Texas System | Methods to Treat Disease States by Influencing the Signaling of Ox-40-Receptors and High Throughput Screening Methods for Identifying Substances Therefor |
EP1981969A4 (en) | 2006-01-19 | 2009-06-03 | Genzyme Corp | ANTI-GITRANT ANTIBODIES FOR THE TREATMENT OF CANCER |
JP2009530391A (ja) | 2006-03-22 | 2009-08-27 | インペリアル・イノベ−ションズ・リミテッド | 免疫系の因子の調節に関連する組成物および方法 |
EP1894940A1 (en) | 2006-08-28 | 2008-03-05 | Apogenix GmbH | TNF superfamily fusion proteins |
CA2947292C (en) | 2006-12-27 | 2019-07-23 | Emory University | Compositions and methods for the treatment of infections and tumors |
EP2009022A1 (en) | 2007-06-26 | 2008-12-31 | Apogenix GmbH | Trimeric death ligands with enhanced activity (tenascin) |
WO2009007120A2 (en) | 2007-07-10 | 2009-01-15 | Apogenix Gmbh | Tnf superfamily collectin fusion proteins |
AU2008275589B2 (en) | 2007-07-12 | 2013-11-21 | Gitr, Inc. | Combination therapies employing GITR binding molecules |
US20090136446A1 (en) | 2007-11-02 | 2009-05-28 | Ludwig Institute For Cancer Research Ltd. | Induction of regulatory t cell-resistant helper cd4+ t cells |
EP3208612B1 (en) | 2008-04-09 | 2019-09-18 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
EP3103875A1 (en) | 2008-07-21 | 2016-12-14 | Apogenix AG | Tnfsf single chain molecules |
CN102149820B (zh) * | 2008-09-12 | 2014-07-23 | 国立大学法人三重大学 | 能够表达外源gitr配体的细胞 |
US9598491B2 (en) | 2008-11-28 | 2017-03-21 | Emory University | Methods for the treatment of infections and tumors |
WO2010078966A1 (en) | 2009-01-09 | 2010-07-15 | Apogenix Gmbh | Fusion proteins forming trimers |
AU2010224094A1 (en) | 2009-03-13 | 2011-09-22 | The Trustees Of The University Of Pennsylvania | OX40/TRAIL fusion proteins |
BR112012004823B1 (pt) | 2009-09-03 | 2021-11-30 | Merck Sharp & Dohme Corp | Anticorpo ou fragmento de ligação de antígeno do mesmo, uso de um anticorpo ou um fragmento de ligação de antígeno do mesmo, e composição farmacêutica |
GB0919054D0 (en) | 2009-10-30 | 2009-12-16 | Isis Innovation | Treatment of obesity |
NO2504364T3 (ru) | 2009-11-24 | 2018-01-06 | ||
ES2638521T5 (es) | 2010-03-05 | 2021-03-02 | Univ Johns Hopkins | Composiciones y métodos para anticuerpos y proteínas de fusión inmunomoduladores dirigidos contra dianas |
US8461311B2 (en) | 2010-06-08 | 2013-06-11 | Washington University | TRAIL trimers, methods and uses therefor |
SG187945A1 (en) | 2010-08-23 | 2013-03-28 | Univ Texas | Anti-ox40 antibodies and methods of using the same |
EP2694550B1 (en) * | 2011-04-01 | 2019-11-27 | Universität Stuttgart | Recombinant tnf ligand family member polypeptides with antibody binding domain and uses thereof |
CA2874998A1 (en) | 2011-05-27 | 2012-12-06 | Cytocure Llc | Methods, compositions, and kits for the treatment of cancer |
US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
US20130071403A1 (en) | 2011-09-20 | 2013-03-21 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
US20150004175A1 (en) | 2011-12-13 | 2015-01-01 | Yale University | Compositions and Methods for Reducing CTL Exhaustion |
TWI476001B (zh) | 2011-12-26 | 2015-03-11 | Ind Tech Res Inst | 三倍體Fc融合蛋白及其用途 |
WO2013107413A1 (zh) | 2012-01-19 | 2013-07-25 | 中国科学院上海巴斯德研究所 | 磷酸化途径相关因子在调控调节性t细胞功能中的应用 |
WO2013119202A1 (en) | 2012-02-06 | 2013-08-15 | Providence Health & Services - Oregon | Cancer treatment and monitoring methods using ox40 agonists |
US9212224B2 (en) | 2012-05-15 | 2015-12-15 | Bristol-Myers Squibb Company | Antibodies that bind PD-L1 and uses thereof |
CN104936982B (zh) | 2012-08-03 | 2020-04-24 | 丹娜法伯癌症研究院 | 抗-pd-l1和pd-l2双结合抗体单一试剂及其使用方法 |
US10081759B2 (en) | 2012-10-09 | 2018-09-25 | Eric John Wernimont | Method, apparatus, and composition for increased recovery of hydrocarbons by paraffin and asphaltene control from reaction of fuels and selective oxidizers in the subterranean environment |
MX363188B (es) | 2012-11-30 | 2019-03-13 | Hoffmann La Roche | Identificación de pacientes con necesidad de coterapia del inhibidor de pd-l1. |
WO2014089113A1 (en) | 2012-12-03 | 2014-06-12 | Bristol-Myers Squibb Company | Enhancing anti-cancer activity of immunomodulatory fc fusion proteins |
US10040841B2 (en) | 2013-01-01 | 2018-08-07 | Kahr Medical Ltd. | Stable form of signal converting protein fusion proteins, and methods of use and preparation thereof |
EP2948475A2 (en) | 2013-01-23 | 2015-12-02 | AbbVie Inc. | Methods and compositions for modulating an immune response |
US20150071910A1 (en) | 2013-03-15 | 2015-03-12 | Genentech, Inc. | Biomarkers and methods of treating pd-1 and pd-l1 related conditions |
EP2970427B1 (en) | 2013-03-15 | 2019-12-25 | Stone, Geoffrey W. | Composition comprised of antigen linked to a tnf superfamily ligand |
BR112016000853A2 (pt) | 2013-07-16 | 2017-12-12 | Genentech Inc | métodos para tratar ou retardar, reduzir ou inibir a recidiva ou a progressão do câncer e a progressão de uma doença imune-relacionada em um indivíduo, para aumentar, melhorar ou estimular uma resposta ou função imune em um indivíduo e kit |
CN105492017B (zh) | 2013-07-19 | 2020-12-01 | 弗拉芒区生物技术研究所 | 靶向经修饰的tnf家族成员 |
AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
WO2015038538A1 (en) | 2013-09-10 | 2015-03-19 | Medimmune, Llc | Compositions and methods for treating sepsis |
EP3161003A2 (en) | 2014-06-27 | 2017-05-03 | Apogenix GmbH | Combination of cd95/cd95l inhibition and cancer immunotherapy |
US9914761B2 (en) | 2014-07-10 | 2018-03-13 | Washington University | Oligomers for TNF superfamily inhibition |
WO2016029043A1 (en) | 2014-08-21 | 2016-02-25 | The General Hospital Corporation | Tumor necrosis factor superfamily and tnf-like ligand muteins and methods of preparing and using the same |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
JP2018500384A (ja) | 2014-11-11 | 2018-01-11 | メディミューン リミテッド | 腫瘍形成を治療するための治療の組合せ |
HUE054122T2 (hu) | 2014-11-14 | 2021-08-30 | Hoffmann La Roche | TNF-családba tartozó ligandum-trimert tartalmazó antigénkötõ molekulák |
WO2016112983A1 (en) | 2015-01-15 | 2016-07-21 | Biontech Ag | Cytokine fusion proteins |
MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
CN107207579B (zh) | 2015-03-31 | 2022-02-25 | 豪夫迈·罗氏有限公司 | 包含三聚体tnf家族配体的抗原结合分子 |
JP6955445B2 (ja) | 2015-04-07 | 2021-10-27 | ジェネンテック, インコーポレイテッド | アゴニスト性の活性を有する抗原結合複合体及びその使用方法 |
US10093742B2 (en) | 2015-07-23 | 2018-10-09 | Inhibrx, Inc. | Multispecific GITR-binding fusion proteins and methods of use thereof |
KR20180033588A (ko) | 2015-08-12 | 2018-04-03 | 메디뮨 리미티드 | Gitrl 융합 단백질 및 그의 용도 |
JP6959229B2 (ja) | 2015-10-23 | 2021-11-02 | アポジェニックス アーゲー | 一本鎖gitr受容体アゴニストタンパク質 |
-
2016
- 2016-02-02 MA MA041460A patent/MA41460A/fr unknown
- 2016-02-03 CA CA2975596A patent/CA2975596A1/en not_active Abandoned
- 2016-02-03 US US15/014,134 patent/US9724390B2/en not_active Expired - Fee Related
- 2016-02-03 BR BR112017016705-0A patent/BR112017016705A2/pt not_active Application Discontinuation
- 2016-02-03 TW TW105103619A patent/TW201643184A/zh unknown
- 2016-02-03 SG SG11201706268XA patent/SG11201706268XA/en unknown
- 2016-02-03 CN CN201680008684.7A patent/CN107406878A/zh active Pending
- 2016-02-03 CN CN201810642593.XA patent/CN109180804A/zh active Pending
- 2016-02-03 EA EA201791313A patent/EA201791313A1/ru unknown
- 2016-02-03 JP JP2017559287A patent/JP2018508233A/ja not_active Withdrawn
- 2016-02-03 EP EP16747162.2A patent/EP3253890A4/en not_active Withdrawn
- 2016-02-03 WO PCT/US2016/016306 patent/WO2016126781A1/en active Application Filing
- 2016-02-03 AU AU2016215394A patent/AU2016215394A1/en not_active Abandoned
- 2016-02-03 KR KR1020177023582A patent/KR20170108073A/ko unknown
- 2016-02-03 MX MX2017009793A patent/MX2017009793A/es unknown
-
2017
- 2017-06-29 US US15/636,711 patent/US10232017B2/en not_active Expired - Fee Related
- 2017-07-12 IL IL253433A patent/IL253433A0/en unknown
- 2017-07-31 PH PH12017501372A patent/PH12017501372A1/en unknown
- 2017-08-09 CO CONC2017/0008047A patent/CO2017008047A2/es unknown
-
2018
- 2018-03-09 HK HK18103319.8A patent/HK1243741A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TW201643184A (zh) | 2016-12-16 |
CA2975596A1 (en) | 2016-08-11 |
US20160256527A1 (en) | 2016-09-08 |
CN109180804A (zh) | 2019-01-11 |
EP3253890A4 (en) | 2018-06-27 |
CO2017008047A2 (es) | 2018-01-05 |
JP2018508233A (ja) | 2018-03-29 |
US20180021407A1 (en) | 2018-01-25 |
US9724390B2 (en) | 2017-08-08 |
PH12017501372A1 (en) | 2017-12-18 |
CN107406878A (zh) | 2017-11-28 |
WO2016126781A4 (en) | 2016-10-13 |
MA41460A (fr) | 2017-12-12 |
US10232017B2 (en) | 2019-03-19 |
AU2016215394A1 (en) | 2017-08-03 |
BR112017016705A2 (pt) | 2018-04-10 |
HK1243741A1 (zh) | 2018-07-20 |
EP3253890A1 (en) | 2017-12-13 |
KR20170108073A (ko) | 2017-09-26 |
MX2017009793A (es) | 2017-10-27 |
SG11201706268XA (en) | 2017-08-30 |
IL253433A0 (en) | 2017-09-28 |
WO2016126781A1 (en) | 2016-08-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201791313A1 (ru) | Агенты, связывающие суперсемейство рецепторов фактора некроза опухоли (tnfrsf), и их применения | |
EA201891121A1 (ru) | Антитела к глюкокортикоид-индуцированному рецептору фактора некроза опухоли (gitr) и их применения | |
PH12016502267A1 (en) | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof | |
CY1125260T1 (el) | Παραγοντες δεσμευσης tigit και χρησεις τους | |
MX2018001787A (es) | Proteinas de fusion del ligando de la proteina relacionada con el receptor de factor de necrosis tumoral inducido por glucorticoides (gitrl) y usos de las mismas. | |
MX360295B (es) | Proteinas de fusion del ligando de ox40 (ox40l) y sus usos. | |
EA201990578A1 (ru) | Связывающие молекулы, которые модулируют биологическую активность, проявляемую клеткой | |
EA201790961A1 (ru) | Перенацеливающие cd3/cd38 t-клетки гетеродимерные иммуноглобулины и способы их получения | |
EA201591478A1 (ru) | Биспецифические антитела против фно и ил-17 | |
MX2017004311A (es) | Anticuerpos del receptor del factor de necrosis tumoral inducido por glucocorticoide (gitr) y metodos de uso de los mismos. | |
WO2018017864A3 (en) | Pvrig-binding agents and uses thereof | |
MX2018000948A (es) | Proteinas de fusion que se unen a gitir multivalentes y multiespecificas. | |
EA201790799A1 (ru) | Композиции и способы для применения для усиления иммунного ответа и терапии злокачественных опухолей | |
EA201890443A1 (ru) | Биспецифичные моновалентные диатела, способные связывать b7-h3 и cd3, и их применение | |
EA201891066A1 (ru) | Антитела к ror1 | |
EA201991207A1 (ru) | Новые агонисты tnfr и их применение | |
EA202191380A1 (ru) | Антитела к альфа-синуклеину и их применение | |
EA201890145A1 (ru) | Антитела к фактору xi и способы их применения | |
MX2022014695A (es) | Anticuerpos anti-gitr y sus usos. | |
RU2016143383A (ru) | Иммуноактивирующая антигенсвязывающая молекула | |
EA201391789A1 (ru) | TNF-АЛЬФА АНТИГЕНСВЯЗЫВАЮЩИЕ БЕЛКИ, ОБЛАДАЮЩИЕ ПОВЫШЕННЫМ СВЯЗЫВАНИЕМ FcRn | |
EA201892097A1 (ru) | АНТИТЕЛА К ФНО-α И ИХ ФУНКЦИОНАЛЬНЫЕ ФРАГМЕНТЫ | |
EA201892440A1 (ru) | Антитела к tl1a и их применения | |
EP2579895A4 (en) | ANTI-VEGF ANTIBODIES AND USES THEREOF | |
EA201890082A1 (ru) | Эпитоп антитела |