EA201791192A1 - Устройство дезинтеграции биологического материала и соответствующие способ производства и способ приготовления клеточных суспензий и микротрансплантатов ткани - Google Patents
Устройство дезинтеграции биологического материала и соответствующие способ производства и способ приготовления клеточных суспензий и микротрансплантатов тканиInfo
- Publication number
- EA201791192A1 EA201791192A1 EA201791192A EA201791192A EA201791192A1 EA 201791192 A1 EA201791192 A1 EA 201791192A1 EA 201791192 A EA201791192 A EA 201791192A EA 201791192 A EA201791192 A EA 201791192A EA 201791192 A1 EA201791192 A1 EA 201791192A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- biological material
- disintegrating
- disintegration
- mesh
- micro
- Prior art date
Links
- 239000012620 biological material Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 230000001413 cellular effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000725 suspension Substances 0.000 title 1
- 238000000465 moulding Methods 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000006285 cell suspension Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229910001220 stainless steel Inorganic materials 0.000 abstract 1
- 239000010935 stainless steel Substances 0.000 abstract 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/08—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers
- B02C18/10—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers with drive arranged above container
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/30—Mincing machines with perforated discs and feeding worms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/30—Mincing machines with perforated discs and feeding worms
- B02C18/36—Knives or perforated discs
- B02C18/362—Knives
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/30—Mincing machines with perforated discs and feeding worms
- B02C18/36—Knives or perforated discs
- B02C18/365—Perforated discs
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/20—Disintegrating by grating
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
- G01N2001/2866—Grinding or homogeneising
Landscapes
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Sampling And Sample Adjustment (AREA)
- Materials For Medical Uses (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Optical Measuring Cells (AREA)
- Prostheses (AREA)
Abstract
Устройство (10) дезинтеграции биологического материала, содержащее полое внешнее тело (11), образующее внутреннюю камеру (12); закрепленную дезинтегрирующую сетку (13), имеющую множество микроотверстий (13а), снабженных острыми краями, располагающуюся поперечно во внутренней камере (12) так, чтобы образовать верхнюю загрузочную камеру (12а), предназначенную для загрузки подлежащего дезинтеграции биологического материала (MB), и нижнюю сборную камеру (12b), предназначенную для сбора биологического материала (MB') после его дезинтеграции; и снабженный лопастью ротор (14), вращающийся во внутренней камере (12), предназначенный для взаимодействия при вращении с закрепленной дезинтегрирующей сеткой (13) так, чтобы подавать биологический материал (MB), содержащийся в верхней загрузочной камере (12а), и обеспечивать его контакт с микроотверстиями (13а) дезинтегрирующей сетки (13), и тем самым вызывать дезинтеграцию биологического материала (MB') при его прохождении через эти микроотверстия. Микроотверстия (13а) дезинтегрирующей сетки имеют размеры или диаметр от 70 до 80 мкм, и получаются посредством процесса формования типа матрица-пуансон с использованием конического или многоугольного пуансона (Р) для вытягивания и разрыва металлического листа (N) из нержавеющей стали так, чтобы каждое микроотверстие имело зубчатый острый край с несколькими кончиками, например шестью, или также с использованием, опять же внутри сферы процесса формования типа матрица-пуансон, источника лазерного света. Как с достаточной точностью установлено с помощью тщательных экспериментальных тестов, благодаря характерным особенностям и конфигурации микроотверстий 13а, посредством устройства (10) дезинтеграции возможно приготавливать без помощи химических реагентов клеточные суспензии и микротрансплантаты ткани, которые сохраняют интактными и неизменными особенности, функции и жизнеспособность исходного недезинтегрированного биологического материала и которые поэтому могут выгодно использоваться в многочисленных медицинских, ветеринарных и косметических приложениях.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI20142143 | 2014-12-15 | ||
| PCT/IB2015/059571 WO2016097960A2 (en) | 2014-12-15 | 2015-12-14 | Disgregating device of biological material and corresponding manufacturing method and method for the preparation of cell suspensions and tissue micrografts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201791192A1 true EA201791192A1 (ru) | 2017-11-30 |
| EA035048B1 EA035048B1 (ru) | 2020-04-22 |
Family
ID=52463058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201791192A EA035048B1 (ru) | 2014-12-15 | 2015-12-14 | Устройство дезинтеграции биологического материала и соответствующие способ производства и способ приготовления клеточных суспензий и микротрансплантатов ткани |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10857544B2 (ru) |
| EP (1) | EP3233289B1 (ru) |
| JP (1) | JP6817953B2 (ru) |
| KR (2) | KR102503809B1 (ru) |
| CN (1) | CN107107068B (ru) |
| AU (1) | AU2015365508B2 (ru) |
| BR (1) | BR112017012740B1 (ru) |
| CA (1) | CA2970426C (ru) |
| CY (1) | CY1122942T1 (ru) |
| DK (1) | DK3233289T3 (ru) |
| EA (1) | EA035048B1 (ru) |
| ES (1) | ES2800908T3 (ru) |
| HK (1) | HK1243672A1 (ru) |
| HR (1) | HRP20200806T1 (ru) |
| HU (1) | HUE051098T2 (ru) |
| IL (2) | IL300579A (ru) |
| LT (1) | LT3233289T (ru) |
| MX (1) | MX2017007932A (ru) |
| PL (1) | PL3233289T3 (ru) |
| PT (1) | PT3233289T (ru) |
| RS (1) | RS60360B1 (ru) |
| SG (1) | SG11201704728YA (ru) |
| SI (1) | SI3233289T1 (ru) |
| WO (1) | WO2016097960A2 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU196578U1 (ru) * | 2020-01-13 | 2020-03-05 | Виктория Игоревна Кузьмина | Устройство для дезинтеграции биологического материала |
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| ES2647458B1 (es) * | 2016-06-21 | 2018-09-28 | Jose Miguel CASANOVA ROSELL | Sistema y método para regeneración capilar a base de microinjertos autólogos de células madre y su uso. |
| ES2652135B1 (es) * | 2016-07-29 | 2018-07-30 | José Miguel CASANOVA ROSELL | Sistema y método para regeneración muscular, tendinosa, cartilaginosa y ósea con microinjertos autólogos de células madre y su uso |
| CN108627370A (zh) * | 2017-03-20 | 2018-10-09 | 深圳华因康基因科技有限公司 | 乳浊液制备仪 |
| KR102051223B1 (ko) * | 2017-09-05 | 2019-12-03 | 이준석 | 생체조직 미세화 장치 |
| CN107837939A (zh) * | 2017-12-05 | 2018-03-27 | 微思行（北京）科技有限公司 | 多杯肉果蔬全自动研磨仪 |
| EP3743507A1 (de) * | 2018-01-24 | 2020-12-02 | FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V. | Vorrichtung und verfahren zur dissoziation von gewebe |
| TW202020137A (zh) * | 2018-08-06 | 2020-06-01 | 日商日產化學股份有限公司 | 用於分割細胞團的裝置及使用該裝置分割細胞團的方法 |
| US20200072712A1 (en) * | 2018-08-29 | 2020-03-05 | Predictive Technology Group, Inc. | Tissue mincers, related systems, and related methods |
| WO2020101622A1 (en) * | 2018-11-12 | 2020-05-22 | T-Bi̇yoteknoloji̇ Laboratuvar Esteti̇k Medi̇kal Kozmeti̇k San Ti̇c Ltd Şti̇ | Blade - filter kit developed to be used for fat transfer |
| US10973472B2 (en) * | 2019-03-05 | 2021-04-13 | Siemens Healthcare Gmbh | Artificial intelligence-based material decomposition in medical imaging |
| KR102202861B1 (ko) * | 2019-04-09 | 2021-01-18 | 이준석 | 스크린 교환 장치, 이를 포함하는 생체조직 미세화 시스템, 이를 이용하는 생체조직 미세화 방법 및 이와 관련된 생체조직으로부터 타겟 물질을 분리하는 방법 |
| US11033295B2 (en) | 2019-05-06 | 2021-06-15 | Tissuemill Technologies Llc | Atraumatically formed tissue composition, devices and methods of preparation and treatment |
| IT201900006854A1 (it) * | 2019-05-15 | 2020-11-15 | Fidia Farm Spa | Dispositivo per disgregare materiale biologico e relativo metodo di disgregazione e preparazioni cellulari |
| CN110124821B (zh) * | 2019-05-18 | 2020-11-06 | 池州灵芝化建材料科技有限公司 | 一种原矿自动分目磨碎收集装置及使用方法 |
| KR102487903B1 (ko) * | 2019-06-02 | 2023-01-12 | (주)카스 인 바이오 | 연질 생체 조직을 미립자화하는 방법 및 이의 방법으로 제조된 연질 생체 조직 미립자 이식편 |
| IT201900014106A1 (it) | 2019-08-06 | 2019-11-06 | Armando Roggero | Dispositivo disgregatore e dissociatore polimerico di materiali biologici solidi per utilizzo medicale e chirurgico rigenerativo |
| CN110643495A (zh) * | 2019-10-31 | 2020-01-03 | 北京伟力新世纪科技发展股份有限公司 | 一种细胞悬浮液制备装置 |
| CN110919706A (zh) * | 2019-11-01 | 2020-03-27 | 上海蓓蕊医疗科技有限公司 | 一种细胞精密切割装置及其使用方法 |
| CN113994187A (zh) * | 2020-01-20 | 2022-01-28 | 基因追踪生物实验室公司 | 用于切碎生物组织的方法和装置 |
| GB2587257B (en) | 2020-03-09 | 2021-09-15 | Alma Lasers Ltd | Lipoaspirate processing |
| KR20230022838A (ko) * | 2020-04-06 | 2023-02-16 | 유니버시티 오브 마이애미 | 조직 처리 디바이스 및 방법 |
| US20220025316A1 (en) * | 2020-07-22 | 2022-01-27 | Prim Sigma Technologies, Inc. | Trituration devices for tissue disaggregation |
| GB2597767A (en) * | 2020-08-04 | 2022-02-09 | Achilles Therapeutics Uk Ltd | Disaggregation device |
| FI20206060A1 (fi) | 2020-10-26 | 2022-04-27 | Epiheart Oy | Laite ja menetelmä kudoksen hajottamiseksi mekaanisesti mikrosiirteiksi sekä kudoksen hajottamisen yhteydessä käytettävä syötinpala |
| CN112500995A (zh) * | 2020-12-22 | 2021-03-16 | 北京金莎科技有限公司 | 一种自体细胞微架构疗法装置 |
| CN112892797B (zh) * | 2021-01-19 | 2021-12-10 | 钱小英 | 一种玻璃生产用残次品粉碎回收再利用装置 |
| US11879121B2 (en) | 2021-04-20 | 2024-01-23 | CisNovo | Tissue disaggregation system and methods |
| CN113640088B (zh) * | 2021-10-19 | 2021-12-14 | 南通中智检测服务有限公司 | 一种用于食品检测的分体粉碎装置 |
| WO2023209039A2 (en) | 2022-04-27 | 2023-11-02 | Gerlach, Jörg C. | Tissue structure isolation using a micro-cutting device and uses of resulting micro-cubes of tissue |
| KR102595329B1 (ko) | 2022-05-09 | 2023-10-30 | 미라셀 주식회사 | 생체조직 분쇄장치 |
| WO2024095300A1 (en) * | 2022-11-03 | 2024-05-10 | Mirco Cavicchioli | Activator device of an agglomerated material and corresponding selection kit and method |
| CN115888918B (zh) * | 2023-03-13 | 2023-09-01 | 济南市莱芜百味食品有限公司 | 一种口蘑粉碎装置 |
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| DE3804339A1 (de) * | 1988-02-12 | 1988-11-03 | Edwin P Schmidt | Fleischauswurfmischer |
| US5172920A (en) | 1992-01-28 | 1992-12-22 | Diamond Manufacturing Co. | Composite material for gaskets |
| IT1260682B (it) | 1993-09-28 | 1996-04-22 | Consult T S S N C Di Roggero G | Dispositivo trituratore meccanico di materiale biologico |
| JPH1058395A (ja) | 1996-08-08 | 1998-03-03 | Ngk Insulators Ltd | 開口用治具および開口機 |
| US20020197631A1 (en) * | 2001-04-26 | 2002-12-26 | Lawrence Nathan P. | Multichamber device and uses thereof for processing of biological samples |
| JP3930300B2 (ja) * | 2001-11-20 | 2007-06-13 | 日本碍子株式会社 | 打抜同時積層用打抜金型 |
| PL2775928T3 (pl) * | 2011-11-08 | 2019-09-30 | Auxocell Laboratories Inc. | Systemy i metody przetwarzania komórek |
| EP3075841B1 (en) * | 2012-09-06 | 2021-03-10 | GID BIO, Inc. | Tissue processing apparatus and method for processing adipose tissue |
| AU2013205148B2 (en) | 2013-03-14 | 2014-10-30 | AVITA Medical Americas, LLC | Systems and methods for tissue processing and preparation of cell suspension therefrom |
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2015
- 2015-12-14 SI SI201531215T patent/SI3233289T1/sl unknown
- 2015-12-14 MX MX2017007932A patent/MX2017007932A/es unknown
- 2015-12-14 LT LTEP15828756.5T patent/LT3233289T/lt unknown
- 2015-12-14 BR BR112017012740-7A patent/BR112017012740B1/pt active IP Right Grant
- 2015-12-14 SG SG11201704728YA patent/SG11201704728YA/en unknown
- 2015-12-14 KR KR1020177018538A patent/KR102503809B1/ko active IP Right Grant
- 2015-12-14 WO PCT/IB2015/059571 patent/WO2016097960A2/en active Application Filing
- 2015-12-14 PT PT158287565T patent/PT3233289T/pt unknown
- 2015-12-14 EP EP15828756.5A patent/EP3233289B1/en active Active
- 2015-12-14 PL PL15828756T patent/PL3233289T3/pl unknown
- 2015-12-14 RS RS20200570A patent/RS60360B1/sr unknown
- 2015-12-14 HU HUE15828756A patent/HUE051098T2/hu unknown
- 2015-12-14 IL IL300579A patent/IL300579A/en unknown
- 2015-12-14 AU AU2015365508A patent/AU2015365508B2/en active Active
- 2015-12-14 DK DK15828756.5T patent/DK3233289T3/da active
- 2015-12-14 ES ES15828756T patent/ES2800908T3/es active Active
- 2015-12-14 JP JP2017549864A patent/JP6817953B2/ja active Active
- 2015-12-14 US US15/535,978 patent/US10857544B2/en active Active
- 2015-12-14 EA EA201791192A patent/EA035048B1/ru unknown
- 2015-12-14 CN CN201580068658.9A patent/CN107107068B/zh active Active
- 2015-12-14 KR KR1020237006168A patent/KR102565995B1/ko active IP Right Grant
- 2015-12-14 CA CA2970426A patent/CA2970426C/en active Active
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2017
- 2017-06-12 IL IL252851A patent/IL252851B2/en unknown
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2018
- 2018-03-09 HK HK18103350.8A patent/HK1243672A1/zh unknown
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2020
- 2020-05-18 HR HRP20200806TT patent/HRP20200806T1/hr unknown
- 2020-05-20 CY CY20201100459T patent/CY1122942T1/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU196578U1 (ru) * | 2020-01-13 | 2020-03-05 | Виктория Игоревна Кузьмина | Устройство для дезинтеграции биологического материала |
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