EA201690951A1 - Мякрнк, композиции и применения - Google Patents

Мякрнк, композиции и применения

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Publication number
EA201690951A1
EA201690951A1 EA201690951A EA201690951A EA201690951A1 EA 201690951 A1 EA201690951 A1 EA 201690951A1 EA 201690951 A EA201690951 A EA 201690951A EA 201690951 A EA201690951 A EA 201690951A EA 201690951 A1 EA201690951 A1 EA 201690951A1
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Eurasian Patent Office
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snornas
aging
relates
individual
well
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EA201690951A
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English (en)
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EA037923B1 (ru
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Жан-Рене Мартен
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Сантр Насьональ Де Ля Решерш Сьянтифик
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Publication of EA201690951A1 publication Critical patent/EA201690951A1/ru
Publication of EA037923B1 publication Critical patent/EA037923B1/ru

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

Настоящее изобретение относится к применению конкретных последовательностей РНК в качестве лекарственного средства. Более конкретно оно относится к применению малых ядрышковых РНК (мякРНК), для которых авторы изобретения продемонстрировали участие в механизмах старения. мякРНК по изобретению можно использовать в частности для повышения устойчивости к стрессу индивидуума, для борьбы с неблагоприятными эффектами старения, как правило, для профилактики или лечения дегенеративного заболевания, ламинопатии, диабета, ожирения или злокачественной опухоли, а также в более широком смысле для увеличения продолжительности жизни индивидуума. мякРНК по изобретению также можно использовать при лечении бесплодия. Изобретение также относится к векторам, клеткам, трансгенным животным и композициям, способным экспрессировать мякРНК по изобретению, а также к способам, в которых используют один из указанных выше продуктов по изобретению, таких как средство идентификации молекулы, которая является активной для профилактики или лечения патологии, аномалии или нарушения, связанного с механизмом старения.
EA201690951A 2013-11-07 2014-11-07 мякРНК, КОМПОЗИЦИИ И ПРИМЕНЕНИЯ EA037923B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1360889A FR3012739A1 (fr) 2013-11-07 2013-11-07 Sno arn, compositions et utilisations
PCT/EP2014/073991 WO2015067727A1 (fr) 2013-11-07 2014-11-07 Sno arn, compositions et utilisations

Publications (2)

Publication Number Publication Date
EA201690951A1 true EA201690951A1 (ru) 2016-10-31
EA037923B1 EA037923B1 (ru) 2021-06-07

Family

ID=51871027

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690951A EA037923B1 (ru) 2013-11-07 2014-11-07 мякРНК, КОМПОЗИЦИИ И ПРИМЕНЕНИЯ

Country Status (17)

Country Link
US (1) US9951332B2 (ru)
EP (1) EP3066199B1 (ru)
JP (2) JP6879738B2 (ru)
KR (1) KR102269438B1 (ru)
CN (1) CN106232816B (ru)
AU (1) AU2014345581B2 (ru)
BR (1) BR112016010342B1 (ru)
CA (1) CA2929732A1 (ru)
DK (1) DK3066199T3 (ru)
EA (1) EA037923B1 (ru)
ES (1) ES2671326T3 (ru)
FR (1) FR3012739A1 (ru)
HU (1) HUE037525T2 (ru)
NO (1) NO3066199T3 (ru)
PT (1) PT3066199T (ru)
TR (1) TR201807186T4 (ru)
WO (1) WO2015067727A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3012739A1 (fr) * 2013-11-07 2015-05-08 Centre Nat Rech Scient Sno arn, compositions et utilisations
CN112020557A (zh) * 2018-03-27 2020-12-01 罗切斯特大学 用于假尿苷化的核酸分子
CN111826432A (zh) * 2019-04-18 2020-10-27 南京大学 细胞去服务化状态的分子标记物检测及其调控方法
WO2021175966A1 (en) 2020-03-04 2021-09-10 Ninovax Products for suppressing or reducing the expression or activity of a snorna and uses thereof in the treatment of cancer
CN116694759B (zh) * 2023-02-17 2023-12-15 中国人民解放军军事科学院军事医学研究院 Scarna12基因调节细胞增殖与存活中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2268749A1 (en) 1996-10-21 1998-04-30 Mcgill University Structural and functional conservation of the c. elegans clock gene clk-1
US6303768B1 (en) 1998-08-07 2001-10-16 California Institute Of Technology Methuselah gene, compositions and methods of use
FR2882062B1 (fr) 2005-02-14 2007-06-15 Commissariat Energie Atomique Vecteurs d'expression stable et de longue duree de sirna et leurs applications
FR3012739A1 (fr) * 2013-11-07 2015-05-08 Centre Nat Rech Scient Sno arn, compositions et utilisations

Also Published As

Publication number Publication date
ES2671326T3 (es) 2018-06-06
EA037923B1 (ru) 2021-06-07
TR201807186T4 (tr) 2018-06-21
CN106232816A (zh) 2016-12-14
US9951332B2 (en) 2018-04-24
EP3066199A1 (fr) 2016-09-14
WO2015067727A1 (fr) 2015-05-14
BR112016010342B1 (pt) 2023-01-31
HUE037525T2 (hu) 2018-09-28
JP6879738B2 (ja) 2021-06-02
AU2014345581B2 (en) 2021-03-11
JP2017502650A (ja) 2017-01-26
AU2014345581A1 (en) 2016-06-23
JP2020010707A (ja) 2020-01-23
KR102269438B1 (ko) 2021-06-24
US20160298112A1 (en) 2016-10-13
FR3012739A1 (fr) 2015-05-08
PT3066199T (pt) 2018-06-05
KR20160079112A (ko) 2016-07-05
CN106232816B (zh) 2021-08-06
BR112016010342A2 (pt) 2017-12-12
NO3066199T3 (ru) 2018-08-18
DK3066199T3 (en) 2018-06-06
CA2929732A1 (fr) 2015-05-14
EP3066199B1 (fr) 2018-03-21

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