EA201592222A1 - Способы получения частиц, содержащих терапевтические белки - Google Patents
Способы получения частиц, содержащих терапевтические белкиInfo
- Publication number
- EA201592222A1 EA201592222A1 EA201592222A EA201592222A EA201592222A1 EA 201592222 A1 EA201592222 A1 EA 201592222A1 EA 201592222 A EA201592222 A EA 201592222A EA 201592222 A EA201592222 A EA 201592222A EA 201592222 A1 EA201592222 A1 EA 201592222A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- protein
- polymer matrix
- combining
- methods
- particles containing
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Настоящее изобретение относится к области фармацевтических препаратов. Конкретнее, изобретение относится к способу получения частицы, содержащей полимерную матрицу и белок. Способ включает следующие стадии: а) отвердение белка из раствора, содержащего белок; b) объединение отвердевшего белка с растворителем, содержащим полимерную матрицу; с) объединение растворителя, содержащего полимерную матрицу и белок, с эмульгатором в воде; d) перемешивание растворителя, содержащего полимерную матрицу, белок и эмульгатор, для образования эмульсии; е) объединение эмульсии, содержащей полимерную матрицу и белок, с водой для допуска образования частиц; и f) извлечение частиц. Кроме того, предложены частица, содержащая полимерную матрицу и белок, полученная с помощью этого способа, а также фармацевтическая композиция, содержащим указанную частицу. Настоящее изобретение обеспечивает усовершенствованный способ получения частиц на основе полимерной матрицы с повышенной эффективностью инкапсуляции.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13168674.3A EP2805708A1 (en) | 2013-05-22 | 2013-05-22 | Methods to produce particles comprising therapeutic proteins |
EP14161988 | 2014-03-27 | ||
PCT/EP2014/060450 WO2014187863A1 (en) | 2013-05-22 | 2014-05-21 | Methods to produce particles comprising therapeutic proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201592222A1 true EA201592222A1 (ru) | 2016-08-31 |
Family
ID=50877246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201592222A EA201592222A1 (ru) | 2013-05-22 | 2014-05-21 | Способы получения частиц, содержащих терапевтические белки |
Country Status (14)
Country | Link |
---|---|
US (1) | US20160090415A1 (ru) |
EP (1) | EP2999459A1 (ru) |
JP (1) | JP2016519152A (ru) |
KR (1) | KR20160009690A (ru) |
CN (1) | CN105338961A (ru) |
AU (1) | AU2014270439A1 (ru) |
BR (1) | BR112015028986A2 (ru) |
CA (1) | CA2912730A1 (ru) |
CL (1) | CL2015003420A1 (ru) |
EA (1) | EA201592222A1 (ru) |
HK (1) | HK1214964A1 (ru) |
MX (1) | MX2015015899A (ru) |
SG (1) | SG11201509450QA (ru) |
WO (1) | WO2014187863A1 (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019528248A (ja) * | 2016-07-18 | 2019-10-10 | ティシュージェン, インク. | 生体分子の立体配座及び構造健全性を維持するための方法及び組成物 |
CN112336873B (zh) | 2020-08-04 | 2022-04-19 | 华南理工大学 | 用于多特异性抗体递送的蛋白型纳米颗粒及其应用、制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100201352B1 (ko) * | 1995-03-16 | 1999-06-15 | 성재갑 | 단일주사 백신 제형 |
EP2044934A1 (en) * | 2007-10-01 | 2009-04-08 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Dispersion of poloxamer-protein particles, methods of manufacturing and uses thereof |
-
2014
- 2014-05-21 EA EA201592222A patent/EA201592222A1/ru unknown
- 2014-05-21 BR BR112015028986A patent/BR112015028986A2/pt not_active IP Right Cessation
- 2014-05-21 SG SG11201509450QA patent/SG11201509450QA/en unknown
- 2014-05-21 WO PCT/EP2014/060450 patent/WO2014187863A1/en active Application Filing
- 2014-05-21 KR KR1020157035935A patent/KR20160009690A/ko not_active Application Discontinuation
- 2014-05-21 US US14/892,325 patent/US20160090415A1/en not_active Abandoned
- 2014-05-21 CN CN201480037271.2A patent/CN105338961A/zh active Pending
- 2014-05-21 AU AU2014270439A patent/AU2014270439A1/en not_active Abandoned
- 2014-05-21 JP JP2016514394A patent/JP2016519152A/ja active Pending
- 2014-05-21 CA CA2912730A patent/CA2912730A1/en not_active Abandoned
- 2014-05-21 MX MX2015015899A patent/MX2015015899A/es unknown
- 2014-05-21 EP EP14727442.7A patent/EP2999459A1/en not_active Withdrawn
-
2015
- 2015-11-20 CL CL2015003420A patent/CL2015003420A1/es unknown
-
2016
- 2016-03-15 HK HK16102997.1A patent/HK1214964A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
BR112015028986A2 (pt) | 2017-07-25 |
JP2016519152A (ja) | 2016-06-30 |
WO2014187863A1 (en) | 2014-11-27 |
US20160090415A1 (en) | 2016-03-31 |
CL2015003420A1 (es) | 2016-09-30 |
CN105338961A (zh) | 2016-02-17 |
EP2999459A1 (en) | 2016-03-30 |
HK1214964A1 (zh) | 2016-08-12 |
SG11201509450QA (en) | 2015-12-30 |
AU2014270439A1 (en) | 2015-12-17 |
CA2912730A1 (en) | 2014-11-27 |
KR20160009690A (ko) | 2016-01-26 |
MX2015015899A (es) | 2016-07-15 |
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