EA201591621A1 - Пригодная для инъекции способная к полимеризации in situ коллагеновая композиция - Google Patents

Пригодная для инъекции способная к полимеризации in situ коллагеновая композиция

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Publication number
EA201591621A1
EA201591621A1 EA201591621A EA201591621A EA201591621A1 EA 201591621 A1 EA201591621 A1 EA 201591621A1 EA 201591621 A EA201591621 A EA 201591621A EA 201591621 A EA201591621 A EA 201591621A EA 201591621 A1 EA201591621 A1 EA 201591621A1
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EA
Eurasian Patent Office
Prior art keywords
injection
composition
collagenic
situ
polymerization
Prior art date
Application number
EA201591621A
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English (en)
Inventor
Дэйл П. Девор
Роберт Дж. Брукс
Тодд Берн
Original Assignee
ДЕРМЕЛЛ, ЭлЭлСи ди/би/эй ИТЕРНОДЖЕН, ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by ДЕРМЕЛЛ, ЭлЭлСи ди/би/эй ИТЕРНОДЖЕН, ЭлЭлСи filed Critical ДЕРМЕЛЛ, ЭлЭлСи ди/би/эй ИТЕРНОДЖЕН, ЭлЭлСи
Publication of EA201591621A1 publication Critical patent/EA201591621A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/95—Involves in-situ formation or cross-linking of polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Polymers & Plastics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к пригодным для инъекции растворимым в кислоте коллагеновым композициям, содержащим нейтрализованный раствор растворимого в кислоте коллагена, ЭДТА и предпочтительно полиола, где композиция является пригодной для инъекции при физиологическом рН, и растворимый в кислоте коллаген полимеризуется после воздействия ткани. Изобретение является пригодным для применения в контурном наращивании мягкой ткани, стимуляции регенерации мягких тканей и покрытии имплантатов и устройств.
EA201591621A 2013-03-04 2014-03-04 Пригодная для инъекции способная к полимеризации in situ коллагеновая композиция EA201591621A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361851119P 2013-03-04 2013-03-04
PCT/US2014/020217 WO2014138021A1 (en) 2013-03-04 2014-03-04 Injectable in situ polymerizable collagen composition

Publications (1)

Publication Number Publication Date
EA201591621A1 true EA201591621A1 (ru) 2015-12-30

Family

ID=51491854

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591621A EA201591621A1 (ru) 2013-03-04 2014-03-04 Пригодная для инъекции способная к полимеризации in situ коллагеновая композиция

Country Status (13)

Country Link
US (2) US10111981B2 (ru)
EP (1) EP2964184B1 (ru)
JP (1) JP6382854B2 (ru)
KR (1) KR20150126647A (ru)
CN (1) CN105209005B (ru)
AU (1) AU2014226064B2 (ru)
BR (1) BR112015021146B1 (ru)
CA (1) CA2901753C (ru)
EA (1) EA201591621A1 (ru)
ES (1) ES2678875T3 (ru)
IL (1) IL240566B (ru)
MX (1) MX370217B (ru)
WO (1) WO2014138021A1 (ru)

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CN117769438A (zh) * 2021-05-13 2024-03-26 上海其胜生物制剂有限公司 包含不可吸收或可缓慢吸收聚合物的组织充填用衍生化或可快速聚合胶原蛋白组合物
CN117915933A (zh) * 2021-09-01 2024-04-19 上海其胜生物制剂有限公司 使用含有软骨细胞或干细胞的可注射可原位聚合胶原组合物进行软骨再生

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Also Published As

Publication number Publication date
JP2016510610A (ja) 2016-04-11
CA2901753C (en) 2023-08-22
EP2964184B1 (en) 2018-05-09
EP2964184A4 (en) 2016-12-07
BR112015021146A2 (pt) 2020-03-10
BR112015021146B1 (pt) 2020-06-30
KR20150126647A (ko) 2015-11-12
IL240566B (en) 2020-05-31
US10111981B2 (en) 2018-10-30
JP6382854B2 (ja) 2018-08-29
CA2901753A1 (en) 2014-09-12
US20150367029A1 (en) 2015-12-24
US11235089B2 (en) 2022-02-01
MX2015011283A (es) 2016-04-04
CN105209005A (zh) 2015-12-30
MX370217B (es) 2019-12-05
AU2014226064A1 (en) 2015-10-15
EP2964184A1 (en) 2016-01-13
WO2014138021A1 (en) 2014-09-12
US20190046686A1 (en) 2019-02-14
AU2014226064B2 (en) 2018-11-01
CN105209005B (zh) 2019-03-12
IL240566A0 (en) 2015-09-24
ES2678875T3 (es) 2018-08-20

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