EA201590127A1 - Новые лиганды холецистокининовых рецепторов - Google Patents
Новые лиганды холецистокининовых рецепторовInfo
- Publication number
- EA201590127A1 EA201590127A1 EA201590127A EA201590127A EA201590127A1 EA 201590127 A1 EA201590127 A1 EA 201590127A1 EA 201590127 A EA201590127 A EA 201590127A EA 201590127 A EA201590127 A EA 201590127A EA 201590127 A1 EA201590127 A1 EA 201590127A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- aryl
- cyclic
- halogen
- alkyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
Abstract
Настоящее изобретение относится к новым соединениям, имеющим нижеприведенную формулу (I)в которой X выбран из водорода, галогена или заместителя и R выбран из водорода, галогена, фенила, арила в соответствии с определением и Y выбран из Н, гидрокси в соответствии с определением и Rвыбран из Н, метила, алкила, Cгрупп с прямой, разветвленной цепью или циклических, насыщенных, ненасыщенных и ароматических гидрокарбильных групп, при этом ароматические группы могут быть гетероциклическими, циклическими или ациклическими и могут быть опциально замещены алкилом, алкинилоксикарбонилом, арилом, бензилом, арилокси, арилкарбонилом и арилоксикарбонилом, эквивалентами серы указанных окси, карбонильных и оксикарбонильных фрагментов, и оксо в соответствии с определением. Настоящее изобретение также относится к их использованию в качестве лигандов холецистокининовых рецепторов и антагонистов холецистокинина, а также к их практическому применению в виде лекарственных препаратов.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2012/000469 WO2014006629A1 (en) | 2012-07-02 | 2012-07-02 | Novel cholecystokinin receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201590127A1 true EA201590127A1 (ru) | 2015-06-30 |
| EA027136B1 EA027136B1 (ru) | 2017-06-30 |
Family
ID=49778756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201590127A EA027136B1 (ru) | 2012-07-02 | 2012-07-02 | Новые лиганды холецистокининовых рецепторов |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8921577B2 (ru) |
| EP (1) | EP2867205B1 (ru) |
| JP (1) | JP6162799B2 (ru) |
| KR (1) | KR20150036333A (ru) |
| CN (1) | CN104411683B (ru) |
| AU (1) | AU2012384456B2 (ru) |
| BR (2) | BR112015000012B1 (ru) |
| CA (1) | CA2877603A1 (ru) |
| EA (1) | EA027136B1 (ru) |
| IL (1) | IL236473B (ru) |
| MX (1) | MX2015000126A (ru) |
| PH (1) | PH12014502845A1 (ru) |
| SG (1) | SG11201408691XA (ru) |
| WO (1) | WO2014006629A1 (ru) |
| ZA (1) | ZA201500220B (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107353239B (zh) | 2017-08-11 | 2019-06-18 | 北京卓凯生物技术有限公司 | 4-氧-烷基化特特拉姆酸类化合物及其制备方法 |
| CN107468690B (zh) | 2017-08-11 | 2020-01-31 | 北京卓凯生物技术有限公司 | 4-氧-烷基化特特拉姆酸类化合物及其制备方法与应用 |
| WO2023079538A1 (en) * | 2021-11-08 | 2023-05-11 | Pnb Vesper Life Science Pvt Limited | A novel process for preparation of 5-hydroxy-5-aryl-pyrrol-2-ones and their intermediates |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1266647A (en) * | 1984-06-26 | 1990-03-13 | William H. Parsons | Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists |
| US5202344A (en) * | 1990-12-11 | 1993-04-13 | G. D. Searle & Co. | N-substituted lactams useful as cholecystokinin antagonists |
| HU213105B (en) * | 1992-12-23 | 1997-05-28 | Richter Gedeon Vegyeszet | Process for producing pyrroline derivatives and pharmaceutical compositions containing them |
| CA2250042A1 (en) * | 1996-03-25 | 1997-10-02 | Eli Lilly And Company | Treating pain using a synergistic combination of an atypical antipsychotic and a drug used in treatment of pain |
| EP2208725A1 (en) * | 2009-01-13 | 2010-07-21 | Hybrigenics S.A. | Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications |
-
2012
- 2012-07-02 EP EP12880513.2A patent/EP2867205B1/en active Active
- 2012-07-02 BR BR112015000012-6A patent/BR112015000012B1/pt active IP Right Grant
- 2012-07-02 JP JP2015519492A patent/JP6162799B2/ja active Active
- 2012-07-02 KR KR20157002800A patent/KR20150036333A/ko not_active Application Discontinuation
- 2012-07-02 CN CN201280074410.XA patent/CN104411683B/zh active Active
- 2012-07-02 AU AU2012384456A patent/AU2012384456B2/en not_active Expired - Fee Related
- 2012-07-02 MX MX2015000126A patent/MX2015000126A/es unknown
- 2012-07-02 CA CA2877603A patent/CA2877603A1/en not_active Abandoned
- 2012-07-02 SG SG11201408691XA patent/SG11201408691XA/en unknown
- 2012-07-02 WO PCT/IN2012/000469 patent/WO2014006629A1/en active Application Filing
- 2012-07-02 EA EA201590127A patent/EA027136B1/ru not_active IP Right Cessation
- 2012-07-02 BR BR112014032777A patent/BR112014032777A2/pt not_active IP Right Cessation
- 2012-07-02 US US13/989,790 patent/US8921577B2/en active Active
-
2014
- 2014-12-22 PH PH12014502845A patent/PH12014502845A1/en unknown
- 2014-12-25 IL IL236473A patent/IL236473B/en not_active IP Right Cessation
-
2015
- 2015-01-13 ZA ZA2015/00220A patent/ZA201500220B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014006629A1 (en) | 2014-01-09 |
| PH12014502845B1 (en) | 2015-02-09 |
| AU2012384456A1 (en) | 2015-02-19 |
| PH12014502845A1 (en) | 2015-02-09 |
| EA027136B1 (ru) | 2017-06-30 |
| EP2867205A1 (en) | 2015-05-06 |
| CN104411683A (zh) | 2015-03-11 |
| US8921577B2 (en) | 2014-12-30 |
| BR112014032777A2 (pt) | 2017-06-27 |
| ZA201500220B (en) | 2016-09-28 |
| AU2012384456B2 (en) | 2018-02-15 |
| BR112015000012A2 (pt) | 2017-06-27 |
| KR20150036333A (ko) | 2015-04-07 |
| EP2867205B1 (en) | 2018-12-19 |
| MX2015000126A (es) | 2015-09-04 |
| US20140005248A1 (en) | 2014-01-02 |
| IL236473B (en) | 2018-08-30 |
| SG11201408691XA (en) | 2015-01-29 |
| JP2015525744A (ja) | 2015-09-07 |
| EP2867205A4 (en) | 2015-11-25 |
| CN104411683B (zh) | 2017-07-07 |
| CA2877603A1 (en) | 2014-01-09 |
| IL236473A0 (en) | 2015-02-26 |
| JP6162799B2 (ja) | 2017-07-12 |
| BR112015000012B1 (pt) | 2022-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |