EA201500335A1 - Диагностика и лечение преэклампсии - Google Patents

Диагностика и лечение преэклампсии

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Publication number
EA201500335A1
EA201500335A1 EA201500335A EA201500335A EA201500335A1 EA 201500335 A1 EA201500335 A1 EA 201500335A1 EA 201500335 A EA201500335 A EA 201500335A EA 201500335 A EA201500335 A EA 201500335A EA 201500335 A1 EA201500335 A1 EA 201500335A1
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Eurasian Patent Office
Prior art keywords
preeclampsia
relates
treatment
disease
female mammals
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EA201500335A
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English (en)
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EA031877B1 (ru
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Стефан Ханссон
Бо Окерстрем
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А1М Фарма Аб
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Publication of EA201500335A1 publication Critical patent/EA201500335A1/ru
Publication of EA031877B1 publication Critical patent/EA031877B1/ru

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    • G—PHYSICS
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/99003—Heme oxygenase (1.14.99.3)
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

Настоящее изобретение относится к биомаркерам преэклампсии, а также лечению данного заболевания. Конкретно, изобретение относится к способам диагностики или способствования диагностике преэклампсии у беременных особей млекопитающего женского пола для обнаружения повышенных уровней свободного гемоглобина, в частности свободного фетального гемоглобина. Это облегчает и делает возможным раннюю диагностику и клиническое вмешательство, когда обнаружено состояние преэклампсии. В дополнение, изобретение относится к способу лечения особей млекопитающих женского пола с преэклампсией с целью вызвать обратное развитие патологических состояний, связанных с этим заболеванием.
EA201500335A 2007-02-12 2008-02-12 Применение альфа-1-микроглобулина для профилактики или лечения преэклампсии EA031877B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0700339 2007-02-12

Publications (2)

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EA201500335A1 true EA201500335A1 (ru) 2016-08-31
EA031877B1 EA031877B1 (ru) 2019-03-29

Family

ID=39295873

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EA200970758A EA022609B1 (ru) 2007-02-12 2008-02-12 Применение свободного фетального гемоглобина в качестве маркера преэклампсии
EA201500335A EA031877B1 (ru) 2007-02-12 2008-02-12 Применение альфа-1-микроглобулина для профилактики или лечения преэклампсии

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EA200970758A EA022609B1 (ru) 2007-02-12 2008-02-12 Применение свободного фетального гемоглобина в качестве маркера преэклампсии

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US (3) US8568999B2 (ru)
EP (3) EP2613150A1 (ru)
JP (2) JP5604111B2 (ru)
KR (2) KR101608501B1 (ru)
AU (1) AU2008214837B2 (ru)
BR (1) BRPI0808340A2 (ru)
CA (1) CA2674204C (ru)
DK (2) DK2111555T3 (ru)
EA (2) EA022609B1 (ru)
ES (2) ES2426069T3 (ru)
HR (2) HRP20130809T1 (ru)
HU (1) HUE031613T2 (ru)
MX (2) MX347788B (ru)
NZ (1) NZ578077A (ru)
PL (2) PL2614832T3 (ru)
PT (2) PT2111555E (ru)
WO (1) WO2008098734A1 (ru)
ZA (1) ZA200905101B (ru)

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EP2614832A1 (en) 2013-07-17
CA2674204C (en) 2017-07-11
JP2014012670A (ja) 2014-01-23
KR101608501B1 (ko) 2016-04-04
EA200970758A1 (ru) 2010-02-26
HRP20161266T1 (hr) 2016-12-16
MX347788B (es) 2017-05-12
PT2614832T (pt) 2016-10-18
DK2111555T3 (da) 2013-09-02
EA022609B1 (ru) 2016-02-29
US8568999B2 (en) 2013-10-29
AU2008214837B2 (en) 2013-01-10
KR20100015315A (ko) 2010-02-12
AU2008214837A1 (en) 2008-08-21
EP2111555A1 (en) 2009-10-28
US20140065170A1 (en) 2014-03-06
US20180284087A1 (en) 2018-10-04
MX2009008408A (es) 2009-11-02
HRP20130809T1 (en) 2013-10-11
ES2426069T3 (es) 2013-10-21
EP2614832B1 (en) 2016-07-13
KR101454013B1 (ko) 2014-11-12
PL2111555T3 (pl) 2013-10-31
NZ578077A (en) 2012-04-27
CA2674204A1 (en) 2008-08-21
EP2111555B1 (en) 2013-05-29
US20100105070A1 (en) 2010-04-29
DK2614832T3 (da) 2016-10-31
JP2010518386A (ja) 2010-05-27
BRPI0808340A2 (pt) 2017-05-30
PT2111555E (pt) 2013-09-04
JP5604111B2 (ja) 2014-10-08
KR20140095572A (ko) 2014-08-01
WO2008098734A1 (en) 2008-08-21
EP2613150A1 (en) 2013-07-10
HUE031613T2 (en) 2017-09-28
ZA200905101B (en) 2012-01-25
US10359406B2 (en) 2019-07-23
ES2599003T3 (es) 2017-01-31
PL2614832T3 (pl) 2017-01-31
JP5792772B2 (ja) 2015-10-14
EA031877B1 (ru) 2019-03-29

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