EA201400938A1 - Способ получения 2-(2,3-диметилфенил)-1-пропаналя с использованием хлорацетона - Google Patents

Способ получения 2-(2,3-диметилфенил)-1-пропаналя с использованием хлорацетона

Info

Publication number
EA201400938A1
EA201400938A1 EA201400938A EA201400938A EA201400938A1 EA 201400938 A1 EA201400938 A1 EA 201400938A1 EA 201400938 A EA201400938 A EA 201400938A EA 201400938 A EA201400938 A EA 201400938A EA 201400938 A1 EA201400938 A1 EA 201400938A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dimethylphenyl
chlorocetone
propane
obtaining
medetomidine
Prior art date
Application number
EA201400938A
Other languages
English (en)
Other versions
EA024425B1 (ru
Inventor
Флоренсио Сарагоса Дёрвальд
Анна Кулеша
Штефан Эльцнер
Роберт Буйок
Збигнев Вробель
Кшиштов Войцеховски
Original Assignee
Лонца Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47558545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201400938(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2012/070879 external-priority patent/WO2012172122A2/en
Application filed by Лонца Лтд. filed Critical Лонца Лтд.
Publication of EA201400938A1 publication Critical patent/EA201400938A1/ru
Publication of EA024425B1 publication Critical patent/EA024425B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/02—Monocyclic aromatic halogenated hydrocarbons
    • C07C25/125—Halogenated xylenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/228—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/105—Saturated compounds containing keto groups bound to acyclic carbon atoms containing rings
    • C07C49/11—Saturated compounds containing keto groups bound to acyclic carbon atoms containing rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/24—Synthesis of the oxirane ring by splitting off HAL—Y from compounds containing the radical HAL—C—C—OY
    • C07D301/26—Y being hydrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Fats And Perfumes (AREA)

Abstract

Изобретение раскрывает способ получения 2-(2,3-диметилфенил)-1-пропаналя исходя из 1-бром 2,3-диметилбензола и хлорацетона, его применение в парфюмерных изделиях и его применение для получения медетомидина.
EA201400938A 2012-06-28 2012-11-15 Способ получения 2-(2,3-диметилфенил)-1-пропаналя с использованием хлорацетона EA024425B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261665528P 2012-06-28 2012-06-28
EP12174104 2012-06-28
EP12189239 2012-10-19
PCT/EP2012/070879 WO2012172122A2 (en) 2012-06-28 2012-10-22 Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
EP12192627 2012-11-14
PCT/EP2012/072799 WO2013011158A2 (en) 2012-06-28 2012-11-15 Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone

Publications (2)

Publication Number Publication Date
EA201400938A1 true EA201400938A1 (ru) 2015-01-30
EA024425B1 EA024425B1 (ru) 2016-09-30

Family

ID=47558545

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400938A EA024425B1 (ru) 2012-06-28 2012-11-15 Способ получения 2-(2,3-диметилфенил)-1-пропаналя с использованием хлорацетона

Country Status (22)

Country Link
US (1) US9126914B1 (ru)
EP (1) EP2867195B1 (ru)
JP (1) JP5779298B2 (ru)
KR (1) KR101537203B1 (ru)
CN (1) CN104220408B (ru)
AU (1) AU2012285678B2 (ru)
BR (1) BR112014022268A8 (ru)
CA (1) CA2866441C (ru)
CL (1) CL2014002906A1 (ru)
CY (1) CY1117491T1 (ru)
DK (1) DK2867195T3 (ru)
EA (1) EA024425B1 (ru)
ES (1) ES2565065T3 (ru)
HK (1) HK1200810A1 (ru)
HR (1) HRP20160250T1 (ru)
HU (1) HUE027383T2 (ru)
IN (1) IN2014DN08121A (ru)
MY (1) MY165118A (ru)
PL (1) PL2867195T3 (ru)
SG (1) SG11201405608QA (ru)
TW (1) TWI535692B (ru)
WO (1) WO2013011158A2 (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2847173T3 (en) 2012-05-08 2016-04-04 Lonza Ag METHOD OF PRODUCING Medetomidine
ES2557638T3 (es) * 2012-05-08 2016-01-27 Lonza Ltd Método para la preparación de 2-(2,3-dimetilfenil)-1-propanal
WO2013011157A1 (en) 2012-06-28 2013-01-24 Lonza Ltd Method for preparation of medetomidine with chloroacetone
MY165118A (en) * 2012-06-28 2018-02-28 Lonza Ag Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
US11221599B2 (en) 2014-11-28 2022-01-11 Signify Holding B.V. Systems and methods for managing environmental conditions
CN106518812A (zh) * 2016-10-25 2017-03-22 湖南大学 一种美托咪定及其中间体的制备方法
CN106749030B (zh) * 2016-12-15 2019-02-12 禚修洁 一种用于icu镇静镇痛的盐酸右美托咪定的制备方法
KR102148289B1 (ko) * 2018-07-04 2020-08-26 에스에프씨주식회사 고효율의 유기 발광 소자
KR102495135B1 (ko) 2019-04-03 2023-02-02 주식회사 엘지에너지솔루션 리튬 이차 전지용 전해질 및 이를 포함하는 리튬 이차 전지
US10550057B1 (en) * 2019-09-04 2020-02-04 Eastman Chemical Company Method of making a dialdeyhde
US10865171B1 (en) 2019-09-04 2020-12-15 Eastman Chemical Company Process to make aromatic enol ethers and olefin isomers of aromatic enol ethers
US10815179B1 (en) 2019-09-04 2020-10-27 Eastman Chemical Company Aromatic dicarbinols
US10858304B1 (en) 2019-09-04 2020-12-08 Eastman Chemical Company Aromatic enol ethers
US10889536B1 (en) 2019-09-04 2021-01-12 Eastman Chemical Company Enol ethers
US10544076B1 (en) 2019-09-04 2020-01-28 Eastman Chemical Company Method of making a dialdeyhde
US11312873B2 (en) 2019-09-04 2022-04-26 Eastman Chemical Company Aromatic enol ether paint additives
US11518899B2 (en) 2019-09-04 2022-12-06 Eastman Chemical Company Aromatic enol ether paint additives
US10865172B1 (en) 2019-09-04 2020-12-15 Eastman Chemical Company Aromatic enol ethers

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BE790604A (fr) 1971-10-28 1973-04-26 Sandoz Sa Nouveaux aminoalcanols, leur preparation et leur application comme medicaments
JPS51100041A (en) * 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
JPS51100042A (en) * 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
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EP0153692B1 (en) * 1984-02-24 1992-07-29 Sagami Chemical Research Center Method for isomerization a glycidate derivative
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SE513474C2 (sv) 1999-01-25 2000-09-18 Hans Elwing Instutionen Foer C Metod för att förhindra kräftdjurs, särskilt havstulpaners, etablering på fasta ytor med hjälp av en substans som stör nervsignaler, varvid substansen är medetomidin, dvs (+)-4-/1- (2,3-dimetylfenyl)-etyl/-IH-imidazol
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DK2847173T3 (en) * 2012-05-08 2016-04-04 Lonza Ag METHOD OF PRODUCING Medetomidine
ES2557638T3 (es) * 2012-05-08 2016-01-27 Lonza Ltd Método para la preparación de 2-(2,3-dimetilfenil)-1-propanal
WO2012172119A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
WO2012172120A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd 2-(2,3-dimethylphenyl)-1-propanal and its use as perfume
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone
MY165118A (en) * 2012-06-28 2018-02-28 Lonza Ag Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
WO2012172122A2 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
WO2013011157A1 (en) * 2012-06-28 2013-01-24 Lonza Ltd Method for preparation of medetomidine with chloroacetone

Also Published As

Publication number Publication date
SG11201405608QA (en) 2014-11-27
CY1117491T1 (el) 2017-04-26
AU2012285678A1 (en) 2014-09-25
KR101537203B1 (ko) 2015-07-22
HUE027383T2 (en) 2016-10-28
HK1200810A1 (zh) 2015-08-14
EP2867195A2 (en) 2015-05-06
NZ700643A (en) 2016-03-31
JP5779298B2 (ja) 2015-09-16
WO2013011158A3 (en) 2013-05-10
TWI535692B (zh) 2016-06-01
WO2013011158A2 (en) 2013-01-24
PL2867195T3 (pl) 2016-06-30
EP2867195B1 (en) 2015-12-30
CA2866441C (en) 2017-01-17
CL2014002906A1 (es) 2014-12-12
US9126914B1 (en) 2015-09-08
EA024425B1 (ru) 2016-09-30
DK2867195T3 (en) 2016-04-04
TW201402533A (zh) 2014-01-16
CA2866441A1 (en) 2013-01-24
BR112014022268A2 (ru) 2017-06-20
HRP20160250T1 (hr) 2016-04-08
US20150239816A1 (en) 2015-08-27
JP2015517475A (ja) 2015-06-22
BR112014022268A8 (pt) 2019-05-28
CN104220408A (zh) 2014-12-17
IN2014DN08121A (ru) 2015-05-01
ES2565065T3 (es) 2016-03-31
KR20140131599A (ko) 2014-11-13
MY165118A (en) 2018-02-28
AU2012285678B2 (en) 2016-02-25
CN104220408B (zh) 2016-01-20

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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