EA201400830A1 - Антибактериальная фармацевтическая композиция - Google Patents

Антибактериальная фармацевтическая композиция

Info

Publication number
EA201400830A1
EA201400830A1 EA201400830A EA201400830A EA201400830A1 EA 201400830 A1 EA201400830 A1 EA 201400830A1 EA 201400830 A EA201400830 A EA 201400830A EA 201400830 A EA201400830 A EA 201400830A EA 201400830 A1 EA201400830 A1 EA 201400830A1
Authority
EA
Eurasian Patent Office
Prior art keywords
preservative
antioxidant
azithromycin
ascorbate
pharmaceutical composition
Prior art date
Application number
EA201400830A
Other languages
English (en)
Other versions
EA027144B1 (ru
Inventor
Борис Викторович ВИОЛИН
Сергей Вячеславович СЕМЁНОВ
Дмитрий Владимирович ПРИСТЕНСКИЙ
Александр Андреевич АНИСЬКОВ
Original Assignee
Общество с ограниченной ответственностью "ВИК-здоровье животных"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Общество с ограниченной ответственностью "ВИК-здоровье животных" filed Critical Общество с ограниченной ответственностью "ВИК-здоровье животных"
Publication of EA201400830A1 publication Critical patent/EA201400830A1/ru
Publication of EA027144B1 publication Critical patent/EA027144B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к области ветеринарии и медицины и может быть использовано для профилактики и лечения бактериальных инфекций. Задачей настоящего изобретения является конструирование препарата на основе азитромицина в виде раствора, обладающего широким спектром антимикробного действия, в виде готового к применению инъекционного раствора не только для внутривенного, но и для внутримышечного, подкожного, внутриматочного и интрацистернального введения. Антибактериальная фармацевтическая композиция включает азитромицин, растворители и/или сорастворители, консервант, антиоксидант. В качестве антиоксиданта используют аскорбиновую кислоту, или аскорбат натрия, или аскорбат кальция, или пальмитил аскорбат, или 4-метил-2,6-дитретбутилфенол, или третбутилгидрохинон, 2,4,5-тригидроксибутирофенон, или метабисульфит натрия, или альфа-токоферол, или тиоглицеринЮ или их комбинации, а в качестве консерванта выбран бензиловый спирт, парабены, хлорэтон или их комбинации, при следующих соотношениях компонентов, мас.%: азитромицин 5-50; антиоксидант 0,1-0,2 ; консервант 1-2; растворители - остальное.
EA201400830A 2012-06-08 2013-06-06 Антибактериальная инъекционная фармацевтическая композиция EA027144B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2012123616/15A RU2512683C2 (ru) 2012-06-08 2012-06-08 Антибактериальная инъекционная фармацевтическая композиция
PCT/RU2013/000467 WO2013184037A2 (ru) 2012-06-08 2013-06-06 Антибактериальная фармацевтическая композиция

Publications (2)

Publication Number Publication Date
EA201400830A1 true EA201400830A1 (ru) 2014-11-28
EA027144B1 EA027144B1 (ru) 2017-06-30

Family

ID=49712781

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400830A EA027144B1 (ru) 2012-06-08 2013-06-06 Антибактериальная инъекционная фармацевтическая композиция

Country Status (9)

Country Link
US (1) US20150126466A1 (ru)
EP (1) EP2859885A4 (ru)
CN (1) CN104470502B (ru)
BR (1) BR112014025017A2 (ru)
EA (1) EA027144B1 (ru)
IN (1) IN2014MN02016A (ru)
MX (1) MX361596B (ru)
RU (1) RU2512683C2 (ru)
WO (1) WO2013184037A2 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2563826C1 (ru) * 2014-08-21 2015-09-20 Общество с ограниченной ответственностью "Научно-внедренческий центр Агроветзащита" Инъекционная антибактериальная фармацевтическая композиция
CN108721209A (zh) * 2017-04-20 2018-11-02 广东东阳光药业有限公司 一种兽用阿奇霉素注射剂
RU2666607C1 (ru) * 2017-05-03 2018-09-11 Общество С Ограниченной Ответственностью "Вик - Здоровье Животных" Способ повышения стабильности инъекционной фармацевтической композиции

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1205338A (zh) * 1998-05-08 1999-01-20 刘万忠 阿奇霉素水溶性盐的合成新方法及其在医药上的用途
US6239112B1 (en) * 1998-07-09 2001-05-29 Merial, Inc. Water miscible macrolide solutions
IT1313610B1 (it) * 1999-08-09 2002-09-09 S I F I Societa Ind Farmaceuti Processo per la preparazione di formulazioni acquose per uso oftalmico
US6787342B2 (en) * 2000-02-16 2004-09-07 Merial Limited Paste formulations
DE60232005D1 (de) 2001-10-18 2009-05-28 Teva Pharma Stabilisierte azithromycin-zusammensetzungen
US20080149521A9 (en) * 2001-10-18 2008-06-26 Michael Pesachovich Methods of stabilizing azithromycin
US7064104B2 (en) 2003-06-13 2006-06-20 The Procter & Gamble Company Methods of managing the symptoms of premenstrual syndrome
WO2005002592A2 (en) 2003-07-01 2005-01-13 Ranbaxy Laboratories Limited Stable oral compositions of azithromycin monohydrate
DE602004019288D1 (de) 2003-07-24 2009-03-19 Pliva Hrvatska D O O Schnellösliches azithromycin in einzeldosisform
RU2255730C1 (ru) * 2003-10-14 2005-07-10 Федеральное государственное унитарное предприятие "Всероссийкий научный центр по безопасности биологически активных веществ" (ФГУП "ВНЦ БАВ") Стабильная фармацевтическая суспензия азитромицина и способ ее получения
CN1270723C (zh) * 2003-11-04 2006-08-23 山西亚宝药业集团股份有限公司 一种阿奇霉素注射液及制备方法
US20050101547A1 (en) 2003-11-06 2005-05-12 Sadatrezaei Mohsen Stabilized azithromycin composition
US20060116336A1 (en) 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
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RU2327453C2 (ru) * 2006-03-28 2008-06-27 Управление ветеринарии Курской области Состав для терапии и профилактики инфекционных заболеваний животных
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CN102283799B (zh) * 2011-08-17 2013-07-31 北京乐维生物技术有限公司 一种阿奇霉素凝胶型滴眼液及其制备工艺

Also Published As

Publication number Publication date
BR112014025017A2 (pt) 2017-08-22
US20150126466A1 (en) 2015-05-07
CN104470502A (zh) 2015-03-25
EP2859885A4 (de) 2016-05-25
WO2013184037A3 (ru) 2014-04-03
RU2012123616A (ru) 2013-12-20
CN104470502B (zh) 2018-11-06
EA027144B1 (ru) 2017-06-30
EP2859885A2 (de) 2015-04-15
MX361596B (es) 2018-12-11
MX2014011345A (es) 2015-05-11
IN2014MN02016A (ru) 2015-08-07
WO2013184037A2 (ru) 2013-12-12
RU2512683C2 (ru) 2014-04-10

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