EA201390603A1 - Многослойная фармацевтическая композиция, содержащая телмисартан и амлодипин - Google Patents
Многослойная фармацевтическая композиция, содержащая телмисартан и амлодипинInfo
- Publication number
- EA201390603A1 EA201390603A1 EA201390603A EA201390603A EA201390603A1 EA 201390603 A1 EA201390603 A1 EA 201390603A1 EA 201390603 A EA201390603 A EA 201390603A EA 201390603 A EA201390603 A EA 201390603A EA 201390603 A1 EA201390603 A1 EA 201390603A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical composition
- composition containing
- containing telmisartan
- amlodipipin
- layer pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к твердой фармацевтической композиции, содержащей телмисартан или его фармацевтически приемлемое производное, возможно один или более чем один подщелачивающий агент и по меньшей мере один блокатор кальциевых каналов. Более конкретно, в изобретении раскрыта фармацевтическая композиция, содержащая телмисартан и амлодипин, которая содержит по меньшей мере один не гигроскопичный наполнитель и/или по меньшей мере одно не гигроскопичное связующее вещество, которое не проявляет разрыхляющего эффекта, и/или по меньшей мере одно гидрофильное смазывающее вещество.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI201000347 | 2010-10-27 | ||
SI201100118 | 2011-03-30 | ||
PCT/EP2011/068806 WO2012055941A1 (en) | 2010-10-27 | 2011-10-26 | Multilayer pharmaceutical composition comprising telmisartan and amlodipine |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201390603A1 true EA201390603A1 (ru) | 2013-11-29 |
EA025946B1 EA025946B1 (ru) | 2017-02-28 |
Family
ID=44907845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201390603A EA025946B1 (ru) | 2010-10-27 | 2011-10-26 | Многослойная фармацевтическая композиция, содержащая телмисартан и амлодипин |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2632438A1 (ru) |
EA (1) | EA025946B1 (ru) |
WO (1) | WO2012055941A1 (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX358211B (es) | 2012-07-23 | 2018-08-10 | Landsteiner Scient S A De C V | Una composición farmacéutica de liberación comprendiendo hidroclorotiazida, losartán y basilato de amlodipino. |
WO2014091263A1 (en) * | 2012-12-11 | 2014-06-19 | Egis Pharmaceuticals Public Limited Company | Telmisartan containing pharmaceutical composition |
CN103271908B (zh) * | 2013-05-23 | 2019-02-12 | 浙江华海药业股份有限公司 | 含有替米沙坦和苯磺酸氨氯地平的口服片剂及其制备方法 |
CN104000821B (zh) * | 2014-06-02 | 2020-06-19 | 浙江华海药业股份有限公司 | 含有替米沙坦和苯磺酸氨氯地平的口服双层片剂及其制备方法 |
CN106619552B (zh) * | 2017-01-04 | 2018-05-25 | 北京汇诚瑞祥医药技术有限公司 | 一种替米沙坦氨氯地平速释片及其制备方法 |
WO2024163030A1 (en) * | 2023-02-03 | 2024-08-08 | Brillian Pharma Inc. | Amlodipine freeze-dried compositions and uses thereof |
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DK161312C (da) | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
SI9210098B (sl) | 1991-02-06 | 2000-06-30 | Dr. Karl Thomae | Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo |
AUPO042396A0 (en) | 1996-06-14 | 1996-07-04 | Procter & Gamble Company, The | Laundry detergent bar containing magnesium sulfate with improved physical properties |
DE19727133A1 (de) | 1997-06-26 | 1999-01-07 | Thomson Brandt Gmbh | Verfahren, Vorrichtung und Aufzeichnungsgerät zur Unterdrückung von impulsartigen Störungen in analogen Audio- und/oder Videosignalen |
DE19901921C2 (de) | 1999-01-19 | 2001-01-04 | Boehringer Ingelheim Pharma | Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels |
DE19917524C2 (de) | 1999-04-17 | 2001-09-20 | Boehringer Ingelheim Pharma | Verfahren zur Nitrierung von Anilinderivaten |
DE10153737A1 (de) | 2001-10-31 | 2003-05-28 | Boehringer Ingelheim Pharma | Kristallines Natriumsalz des Telmisartans, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels |
DE10314702A1 (de) | 2003-03-31 | 2004-10-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von Telmisartan |
CN1548421A (zh) | 2003-05-22 | 2004-11-24 | 上海医药工业研究院 | 替米沙坦盐及其制备方法 |
GB2414019A (en) | 2004-05-11 | 2005-11-16 | Cipla Ltd | One-step preparation of telmisartan by condensation and hydrolysis |
KR20070061583A (ko) | 2004-10-15 | 2007-06-13 | 테바 파마슈티컬 인더스트리즈 리미티드 | 텔미사르탄의 제조 방법 |
WO2006044754A2 (en) | 2004-10-18 | 2006-04-27 | Dr. Reddy's Laboratories Ltd. | Process for preparing telmisartan |
JP2008516001A (ja) | 2004-11-03 | 2008-05-15 | テバ ファーマシューティカル インダストリーズ リミティド | 非晶質、および多形のフォームのテルミサルタン・ナトリウム |
EP1814527B2 (en) | 2004-11-05 | 2020-11-18 | Boehringer Ingelheim International GmbH | Bilayer tablet comprising telmisartan and amlodipine |
US20090012140A1 (en) | 2004-11-11 | 2009-01-08 | Lek Pharmaceuticals D.D | Preparation of Telmisartan Salts with Improved Solubility |
US20060111417A1 (en) | 2004-11-23 | 2006-05-25 | Purandhar Koilkonda | Amorphous telmisartan |
EP1833801B9 (en) | 2004-12-22 | 2009-02-25 | Algry Quimica, S.L | Intermediate compounds for the preparation of angiotensin ii receptor antagonists |
US20060211866A1 (en) | 2005-03-21 | 2006-09-21 | Glenmark Pharmaceuticals Limited | Process for the preparation of angiotensin receptor blockers and intermediates thereof |
ITMI20050801A1 (it) | 2005-05-03 | 2006-11-04 | Dipharma Spa | Procedimento per la preparazione di telmisartan |
JP2006321798A (ja) | 2005-05-18 | 2006-11-30 | Chemagis Ltd | 医薬組成物のために好適な高純度のテルミサルタン型aを製造するための改良された方法 |
TWI388345B (zh) | 2005-06-27 | 2013-03-11 | Sankyo Co | 用於高血壓之預防或治療之包含血管緊張素ⅱ受體拮抗劑及鈣通道阻斷劑之固體劑型 |
US7884214B2 (en) | 2005-07-19 | 2011-02-08 | Matrix Laboratories Limited | Process for the preparation of Telmisartan |
US20060264491A1 (en) | 2006-06-08 | 2006-11-23 | Chemagis Ltd. | Telmisartan production process |
SI22297A (sl) | 2006-06-23 | 2007-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Priprava soli telmisartana |
KR100888131B1 (ko) * | 2006-10-10 | 2009-03-11 | 한올제약주식회사 | 시간차 투약 원리를 이용한 심혈관계 질환 치료용 복합제제 |
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CZ302272B6 (cs) | 2007-07-09 | 2011-01-19 | Zentiva, A. S. | Zpusob výroby 4´-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-karboxylové kyseliny (telmisartanu) |
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EP2123648A1 (en) | 2008-05-20 | 2009-11-25 | Chemo Ibérica, S.A. | A process for the preparation of Telmisartan. |
WO2010004385A1 (en) | 2008-06-17 | 2010-01-14 | Aurobindo Pharma Limited | Process for the preparation of pure 4'-[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid |
WO2010018441A2 (en) | 2008-08-11 | 2010-02-18 | Cadila Pharmaceuticals Ltd. | An improved process for the preparation of substantially pure telmisartan |
JP5614557B2 (ja) * | 2009-05-27 | 2014-10-29 | ダサン メディケム カンパニー リミテッド | 発泡層を含む多層錠剤 |
PL2443094T3 (pl) | 2009-06-19 | 2013-08-30 | Krka Tovarna Zdravil D D Novo Mesto | Sposób wytwarzania telmisartanu |
EP2277866A1 (en) | 2009-06-22 | 2011-01-26 | Inke, S.A. | Process for preparing telmisartan |
CN101983962A (zh) | 2010-12-07 | 2011-03-09 | 福州海王福药制药有限公司 | 替米沙坦原料药的制备工艺 |
-
2011
- 2011-10-26 EP EP11779142.6A patent/EP2632438A1/en not_active Withdrawn
- 2011-10-26 EA EA201390603A patent/EA025946B1/ru not_active IP Right Cessation
- 2011-10-26 WO PCT/EP2011/068806 patent/WO2012055941A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2012055941A1 (en) | 2012-05-03 |
EA025946B1 (ru) | 2017-02-28 |
EP2632438A1 (en) | 2013-09-04 |
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Legal Events
Date | Code | Title | Description |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |