EA201390362A1 - Новые аналоги пиперазина в качестве противовирусных препаратов широкого спектра действия против гриппа - Google Patents

Новые аналоги пиперазина в качестве противовирусных препаратов широкого спектра действия против гриппа

Info

Publication number
EA201390362A1
EA201390362A1 EA201390362A EA201390362A EA201390362A1 EA 201390362 A1 EA201390362 A1 EA 201390362A1 EA 201390362 A EA201390362 A EA 201390362A EA 201390362 A EA201390362 A EA 201390362A EA 201390362 A1 EA201390362 A1 EA 201390362A1
Authority
EA
Eurasian Patent Office
Prior art keywords
piperazin
wide range
action against
virus drugs
new analogues
Prior art date
Application number
EA201390362A
Other languages
English (en)
Other versions
EA023258B1 (ru
Inventor
Кристофер В. Сианси
Самюэл Герритц
Гуо Ли
Бредли С. Пирс
Аннапурна Пендри
Шухао Ши
Вэйсюй Чжай
Шижун Чжу
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA201390362A1 publication Critical patent/EA201390362A1/ru
Publication of EA023258B1 publication Critical patent/EA023258B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Предложено соединение формулы (I), в том числе его фармацевтически приемлемые соли:в котором Het представляет собой 5- или 6-членный гетероцикл с -N, -О или -S, смежным с -Ar заместителем или смежный с точкой присоединения -Ar заместителя; Ar представляет собой арил или гетероарил; R представляет собой -СН, -CHF или -СН=СН; W представляет собой -NO, -Cl, -Br, -СНО, -СН=СНили -CN; X представляет собой -Cl, -СНили -CN; Y представляет собой -СН или -N; Z представляет собой C-Cалкил, C-Cциклоалкил, замещенный арил, замещенный гетероарил, ORили NHR, в которых Rвыбран из группы Н, арила, гетероарила, C-Cалкила и C-Cциклоалкила. Данное соединение в составе композиций пригодно для предупреждения и лечения вируса гриппа.
EA201390362A 2010-09-08 2011-09-06 1,4-пиперазиновые производные в качестве средства от вирусного гриппа EA023258B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38072810P 2010-09-08 2010-09-08
PCT/US2011/050504 WO2012033736A1 (en) 2010-09-08 2011-09-06 Novel piperazine analogs as broad-spectrum influenza antivirals

Publications (2)

Publication Number Publication Date
EA201390362A1 true EA201390362A1 (ru) 2013-07-30
EA023258B1 EA023258B1 (ru) 2016-05-31

Family

ID=44653573

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390362A EA023258B1 (ru) 2010-09-08 2011-09-06 1,4-пиперазиновые производные в качестве средства от вирусного гриппа

Country Status (17)

Country Link
US (1) US8362004B2 (ru)
EP (1) EP2614052B1 (ru)
JP (1) JP5902172B2 (ru)
CN (1) CN103201268B (ru)
BR (1) BR112013005552A2 (ru)
CA (1) CA2809624A1 (ru)
DK (1) DK2614052T3 (ru)
EA (1) EA023258B1 (ru)
ES (1) ES2533068T3 (ru)
HR (1) HRP20150228T1 (ru)
MX (1) MX2013002557A (ru)
PL (1) PL2614052T3 (ru)
PT (1) PT2614052E (ru)
RS (1) RS53844B1 (ru)
SI (1) SI2614052T1 (ru)
SM (1) SMT201500068B (ru)
WO (1) WO2012033736A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101369584B1 (ko) 2011-04-19 2014-03-06 일양약품주식회사 페닐-이속사졸 유도체 및 그의 제조방법
CN105101959B (zh) * 2012-11-05 2018-04-17 南特知识产权控股有限责任公司 作为刺猬信号传导通路的抑制剂的含有环状磺酰胺的衍生物
KR102089122B1 (ko) * 2016-08-25 2020-03-13 주식회사 엘지화학 디아민 화합물 및 이를 이용하여 제조된 플렉시블 소자용 기판
US11040963B2 (en) 2017-02-02 2021-06-22 Janssen Vaccines & Prevention B.V. Piperazine derivatives for influenza virus inhibitions
WO2018141854A1 (en) 2017-02-02 2018-08-09 Janssen Vaccines & Prevention B.V. Piperazine derivatives for influenza virus inhibition
WO2021204923A1 (en) * 2020-04-09 2021-10-14 Vironova Medical Ab Antiviral agents
WO2021204924A1 (en) * 2020-04-09 2021-10-14 Vironova Medical Ab Compounds for use in the treatment of hypercytokinemia

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9914371D0 (en) * 1999-06-18 1999-08-18 Smithkline Beecham Plc Novel compounds
KR20040010713A (ko) * 2001-06-15 2004-01-31 야마노우치세이야쿠 가부시키가이샤 페닐피리딘 카보닐 피페라진 유도체
AU2003246972A1 (en) 2002-08-06 2004-02-23 Astrazeneca Ab Condensed pyridines and pyrimidines with tie2 (tek) activity
WO2004078732A1 (fr) 2003-01-28 2004-09-16 Aventis Pharma S.A. Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
US6949865B2 (en) * 2003-01-31 2005-09-27 Betabatt, Inc. Apparatus and method for generating electrical current from the nuclear decay process of a radioactive material
GB0428235D0 (en) 2004-12-23 2005-01-26 Glaxo Group Ltd Novel compounds
EP1834954A1 (en) * 2006-03-15 2007-09-19 4Sc Ag Thiazoles as NF-kB Inhibitors (proteasome inhibitors)
AU2010281265A1 (en) * 2009-08-05 2012-03-22 Versitech Limited Antiviral compounds and methods of making and using thereof

Also Published As

Publication number Publication date
PT2614052E (pt) 2015-03-31
PL2614052T3 (pl) 2015-06-30
SMT201500068B (it) 2015-05-05
WO2012033736A1 (en) 2012-03-15
US20120238539A1 (en) 2012-09-20
CN103201268B (zh) 2015-08-12
BR112013005552A2 (pt) 2016-05-03
EP2614052B1 (en) 2014-12-31
SI2614052T1 (sl) 2015-04-30
EP2614052A1 (en) 2013-07-17
DK2614052T3 (en) 2015-04-07
ES2533068T3 (es) 2015-04-07
RS53844B1 (en) 2015-08-31
CN103201268A (zh) 2013-07-10
JP2013537193A (ja) 2013-09-30
JP5902172B2 (ja) 2016-04-13
HRP20150228T1 (hr) 2015-04-10
US8362004B2 (en) 2013-01-29
EA023258B1 (ru) 2016-05-31
CA2809624A1 (en) 2012-03-15
MX2013002557A (es) 2013-05-28

Similar Documents

Publication Publication Date Title
EA201390476A1 (ru) Новые пиперазиновые аналоги с замещенными гетероарильными группами в качестве противовирусных средств широкого применения против гриппа
EA201390362A1 (ru) Новые аналоги пиперазина в качестве противовирусных препаратов широкого спектра действия против гриппа
EA201690019A1 (ru) Производное аминотриазина и содержащая его фармацевтическая композиция
PH12015501473A1 (en) Novel antiviral agents against hbv infection
AR059622A1 (es) Quinolonas utiles como inhibidores de la sintetasa del oxido nitrico inducibles
NZ739248A (en) Inhibitors of hepatitis c virus
EA200970478A1 (ru) Аналоги тиофена для лечения или предупреждения флавивирусных инфекций
CA2875877C (en) Syk inhibitors
EA201491179A1 (ru) 2',4'-дифтор-2'-метил замещенные нуклеозидные производные в качестве ингибиторов репликации рнк вируса гепатита с
ATE463483T1 (de) 6-substituierte isochinolinderivate als rock-1- inhibitoren
EA201201378A1 (ru) Определенные аминопиримидины, композиции на их основе и способы их использования
EA201100482A1 (ru) Кристаллические формы 2-тиазолил-4-хинолинилоксипроизводного, активного ингибитора hcv
EA200901101A1 (ru) Макроциклические соединения в качестве ингибиторов протеазы ns3 вгс
BRPI1009333B8 (pt) compostos inibidores de beta-secretase, seus usos, bem como composição farmacêutica
AR093659A1 (es) Derivados ciclicos de nucleosidos y usos de los mismos
AR085203A1 (es) Inhibidores benzimidazol del virus sincitial respiratorio
EA200901241A1 (ru) Соединения для лечения гепатита с
EA201590023A1 (ru) Новые 4-замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса
EA201170456A1 (ru) Синергические комбинации макроциклического ингибитора вируса гепатита с и нуклеозида
EA201600241A1 (ru) Замещенные (2r,3r,5r)-3-гидрокси-(5-пиримидин-1-ил)тетрагидрофуран-2-илметил арил фосфорамидаты
RS53940B1 (en) HETEROARYL UNITS AS LIGANDS OF 5-HT4 RECEPTORS
EA201491525A1 (ru) Спиро[2.4]гептаны для лечения инфекций, вызванных flaviviridae
AR065249A1 (es) Derivados nitrogenados condensados de analogos de nucleosidos, composiciones farmaceuticas que los contienen y usos para tratar y/o prevenir infecciones virales.
UY33150A (es) Compuestos carboxamida y su uso como inhibidores v de calpaína
AR083723A1 (es) Inhibidores del virus de la hepatitis c

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU