EA201301186A1 - Способ производства фармацевтических изделий из расплавленного материала - Google Patents

Способ производства фармацевтических изделий из расплавленного материала

Info

Publication number
EA201301186A1
EA201301186A1 EA201301186A EA201301186A EA201301186A1 EA 201301186 A1 EA201301186 A1 EA 201301186A1 EA 201301186 A EA201301186 A EA 201301186A EA 201301186 A EA201301186 A EA 201301186A EA 201301186 A1 EA201301186 A1 EA 201301186A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cooling medium
knife
perforated plate
molten material
granules
Prior art date
Application number
EA201301186A
Other languages
English (en)
Other versions
EA024166B1 (ru
Inventor
Райнхардт-Карстен Мюрб
Original Assignee
Аутоматик Плэстикс Машинери Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аутоматик Плэстикс Машинери Гмбх filed Critical Аутоматик Плэстикс Машинери Гмбх
Publication of EA201301186A1 publication Critical patent/EA201301186A1/ru
Publication of EA024166B1 publication Critical patent/EA024166B1/ru

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/02—Making granules by dividing preformed material
    • B29B9/06—Making granules by dividing preformed material in the form of filamentary material, e.g. combined with extrusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/02—Making granules by dividing preformed material
    • B29B9/06—Making granules by dividing preformed material in the form of filamentary material, e.g. combined with extrusion
    • B29B9/065—Making granules by dividing preformed material in the form of filamentary material, e.g. combined with extrusion under-water, e.g. underwater pelletizers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
    • B29C48/04—Particle-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/16—Cooling
    • B29C2035/1658—Cooling using gas

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение касается способа для производства фармацевтических изделий из расплавленного материала, причём расплавленный материал выходит из сопел в перфорированной пластине и затем гранулируется, и причём режущее устройство по меньшей мере с одним ножом приводится в движение от двигателя, который располагается напротив перфорированной пластины, так что по меньшей мере один нож перекрывает сопла в перфорированной пластине и при этом отделяет гранулы из выходящего расплавленного материала, причём предусматривается корпус, который примыкает к перфорированной пластине, по меньшей мере, окружает по меньшей мере один нож режущего устройства и по нему протекает охлаждающая среда, так что при этом гранулы из расплавленного материала затвердевают в охлаждающей среде, которая вводится из приточного устройства, образованного из приточной камеры, которую в пространстве окружает корпус в зоне вращения по меньшей мере одного ножа, и из проходящего в пространстве устройства приточных сопел между приточными камерами и корпусом в пространстве со всех сторон радиально снаружи вовнутрь в корпус, причём, по меньшей мере, в зоне вращения образуется центростремительный или, по меньшей мере, главным образом, центростремительный поток охлаждающей среды, и затем охлаждающая среда и находящиеся в ней гранулы направляются в выпускное отверстие в корпусе, причём охлаждающая среда является газообразной охлаждающей средой.
EA201301186A 2011-04-21 2012-04-19 Способ производства фармацевтических изделий из расплавленного материала EA024166B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011018403A DE102011018403A1 (de) 2011-04-21 2011-04-21 Verfahren zur Herstellung von pharmazeutischen Erzeugnissen aus einem Schmelzematerial
PCT/EP2012/001703 WO2012143133A1 (de) 2011-04-21 2012-04-19 Verfahren zur herstellung von pharmazeutischen erzeugnissen aus einem schmelzematerial

Publications (2)

Publication Number Publication Date
EA201301186A1 true EA201301186A1 (ru) 2014-11-28
EA024166B1 EA024166B1 (ru) 2016-08-31

Family

ID=45999775

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201301186A EA024166B1 (ru) 2011-04-21 2012-04-19 Способ производства фармацевтических изделий из расплавленного материала

Country Status (13)

Country Link
US (1) US20140042659A1 (ru)
EP (1) EP2699235B1 (ru)
JP (2) JP2014512225A (ru)
KR (1) KR20140026402A (ru)
CN (1) CN103533924B (ru)
BR (1) BR112013026848B1 (ru)
DE (1) DE102011018403A1 (ru)
EA (1) EA024166B1 (ru)
HU (1) HUE031128T2 (ru)
MX (1) MX354376B (ru)
PL (1) PL2699235T3 (ru)
TW (1) TWI578981B (ru)
WO (1) WO2012143133A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013018239A1 (de) * 2013-10-30 2015-04-30 Automatik Plastics Machinery Gmbh Granuliervorrichtung mit Schneidmesserkopf
CN109674656A (zh) * 2019-01-15 2019-04-26 苏州璞佩珊科技有限公司 一种制备药物制剂的方法
DE102019127666A1 (de) 2019-10-15 2021-04-15 Maag Automatik Gmbh Lochplatte zum Granulieren von Schmelzen sowie Verfahren zu deren Herstellung
CN113843914A (zh) * 2021-08-05 2021-12-28 卢琨 一种塑料颗粒大小相同的节能式生产加工辅助设备

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2825639C3 (de) * 1978-06-12 1981-08-27 Hermann Berstorff Maschinenbau Gmbh, 3000 Hannover Einrichtung zum Granulieren von Kunststoffschmelzen und plastischen Massen
GB8814437D0 (en) * 1988-06-17 1988-07-20 Farrel Ltd Apparatus for use in producing pellets
CA2084409A1 (en) * 1991-04-10 1992-10-11 Masao Moriyama Apparatus for producing plastic pellets
DE4138513A1 (de) * 1991-11-23 1993-05-27 Basf Ag Feste pharmazeutische retardform
DE4413350A1 (de) * 1994-04-18 1995-10-19 Basf Ag Retard-Matrixpellets und Verfahren zu ihrer Herstellung
DE19846286C2 (de) * 1998-10-08 2002-11-28 Peter Schelauske Granuliervorrichtung
DE10137524A1 (de) * 2001-08-01 2003-02-13 Rieter Automatik Gmbh Vorrichtung zum Granulieren von aus Düsen austretenden thermoplastischem Kunststoff
DE10219228A1 (de) * 2002-04-30 2003-11-13 Symrise Gmbh & Co Kg Aromapartikel
DE102004007713A1 (de) * 2004-02-16 2005-09-01 Leistritz Extrusionstechnik Gmbh Vorrichtung zur Herstellung gerundeter Pellets
ES2556251T3 (es) * 2006-03-22 2016-01-14 Basf Se Proceso para granular polímeros fundidos que contienen sustancias con puntos bajos de ebullición
DE102006022555B4 (de) * 2006-05-15 2010-12-16 Rieter Automatik Gmbh Vorrichtung und Verfahren zur Erzeugung eines Granulats aus einer Kunststoffschmelze
DE102006058510A1 (de) * 2006-12-12 2008-06-19 Bühler AG Verfahren und Vorrichtung zur Herstellung und Behandlung von Granulatkörnern
DE202007003495U1 (de) * 2007-03-08 2007-07-05 Rieter Automatik Gmbh Vorrichtung zur Erzeugung von Granulatkörnern aus einer Kunststoffschmelze
ITMI20071005A1 (it) * 2007-05-18 2008-11-19 Polimeri Europa Spa Procedimento per la preparazione di granuli a base di polimeri termoplastici espandibili e relativo prodotto
JP4819952B2 (ja) * 2007-08-21 2011-11-24 株式会社日本触媒 アクリル系樹脂パッケージ体
DE102007040135A1 (de) * 2007-08-24 2009-02-26 Bkg Bruckmann & Kreyenborg Granuliertechnik Gmbh Verfahren zur Herstellung von Polyester-Granulaten aus hochviskosen Polyester-Schmelzen sowie Vorrichtung zur Herstellung der Polyester-Granulate
DE102009006123B4 (de) 2009-01-26 2019-01-10 Maag Automatik Gmbh Verfahren und Vorrichtung zum Granulieren von thermoplastischem Kunststoffmaterial
DE102010015776A1 (de) * 2010-04-21 2011-10-27 Automatik Plastics Machinery Gmbh Vorrichtung und Verfahren zur Herstellung von Granulatkörnern
DE102013015190A1 (de) * 2013-09-11 2015-03-12 Automatik Plastics Machinery Gmbh Verfahren zur Herstellung von oberflächig kristallinen sphärischen Granulaten mittelsTrockenheißabschlag und Vorrichtung zur Durchführung des Verfahrens

Also Published As

Publication number Publication date
HUE031128T2 (en) 2017-06-28
MX354376B (es) 2018-02-28
EP2699235B1 (de) 2017-01-11
US20140042659A1 (en) 2014-02-13
JP2014512225A (ja) 2014-05-22
WO2012143133A1 (de) 2012-10-26
KR20140026402A (ko) 2014-03-05
EA024166B1 (ru) 2016-08-31
CN103533924B (zh) 2015-11-25
TWI578981B (zh) 2017-04-21
DE102011018403A1 (de) 2012-10-25
TW201242590A (en) 2012-11-01
JP2017094172A (ja) 2017-06-01
PL2699235T3 (pl) 2017-07-31
EP2699235A1 (de) 2014-02-26
MX2013012249A (es) 2014-04-25
BR112013026848B1 (pt) 2020-12-22
CN103533924A (zh) 2014-01-22

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU