EA201291052A1 - Ингибиторы протеинтирозинкиназной активности - Google Patents

Ингибиторы протеинтирозинкиназной активности

Info

Publication number
EA201291052A1
EA201291052A1 EA201291052A EA201291052A EA201291052A1 EA 201291052 A1 EA201291052 A1 EA 201291052A1 EA 201291052 A EA201291052 A EA 201291052A EA 201291052 A EA201291052 A EA 201291052A EA 201291052 A1 EA201291052 A1 EA 201291052A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
proteintirozinkinase
inhibition
conditions
tyrosine kinase
Prior art date
Application number
EA201291052A
Other languages
English (en)
Russian (ru)
Inventor
Стефан Раппель
Фрэнк Раппель
Стефен Уилльям Кларидж
Лицзе Чжань
Фредерик Годетт
Майкл Мэннион
Норифуми Сато
Йохей Юки
Масаси Кисида
Аркадий Вайсбург
Original Assignee
Метилджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Метилджен Инк. filed Critical Метилджен Инк.
Publication of EA201291052A1 publication Critical patent/EA201291052A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EA201291052A 2010-04-16 2011-04-08 Ингибиторы протеинтирозинкиназной активности EA201291052A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32480310P 2010-04-16 2010-04-16
PCT/CA2011/000394 WO2011127567A1 (en) 2010-04-16 2011-04-08 Inhibitors of protein tyrosine kinase activity

Publications (1)

Publication Number Publication Date
EA201291052A1 true EA201291052A1 (ru) 2013-04-30

Family

ID=44788641

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201291052A EA201291052A1 (ru) 2010-04-16 2011-04-08 Ингибиторы протеинтирозинкиназной активности
EA201291055A EA201291055A1 (ru) 2010-04-16 2011-04-08 Ингибиторы протеинтирозинкиназной активности и их применение для лечения глазных заболеваний

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201291055A EA201291055A1 (ru) 2010-04-16 2011-04-08 Ингибиторы протеинтирозинкиназной активности и их применение для лечения глазных заболеваний

Country Status (19)

Country Link
US (3) US8906852B2 (cg-RX-API-DMAC7.html)
EP (2) EP2563794A4 (cg-RX-API-DMAC7.html)
JP (2) JP2013523846A (cg-RX-API-DMAC7.html)
KR (2) KR20130058006A (cg-RX-API-DMAC7.html)
CN (2) CN102947315A (cg-RX-API-DMAC7.html)
AR (2) AR080871A1 (cg-RX-API-DMAC7.html)
AU (2) AU2011241422B2 (cg-RX-API-DMAC7.html)
CA (2) CA2796008A1 (cg-RX-API-DMAC7.html)
CO (2) CO6640224A2 (cg-RX-API-DMAC7.html)
EA (2) EA201291052A1 (cg-RX-API-DMAC7.html)
MX (2) MX2012012031A (cg-RX-API-DMAC7.html)
MY (1) MY157319A (cg-RX-API-DMAC7.html)
NZ (2) NZ602954A (cg-RX-API-DMAC7.html)
PH (2) PH12012502070A1 (cg-RX-API-DMAC7.html)
SG (2) SG184883A1 (cg-RX-API-DMAC7.html)
TW (2) TW201204735A (cg-RX-API-DMAC7.html)
UA (1) UA108878C2 (cg-RX-API-DMAC7.html)
WO (2) WO2011127567A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA201207482B (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2183254B1 (en) * 2007-08-29 2017-06-21 MethylGene Inc. Inhibitors of protein tyrosine kinase activity
MX2010009729A (es) * 2008-03-05 2010-12-21 Methylgene Inc Inhibidores de actividad de proteina tirosina quinasa.
MX2012012031A (es) * 2010-04-16 2012-12-17 Methylgene Inc Inhibidores de la actividad de la proteina tirosina quinasa y uso de los mismos para tratar transtornos oftalmicos.
US20130090327A1 (en) * 2011-09-30 2013-04-11 Methylgene Inc. Inhibitors of Protein Tyrosine Kinase Activity
WO2013044361A1 (en) * 2011-09-30 2013-04-04 Methylgene Inc. Inhibitors of protein tyrosine kinase activity
US20130096135A1 (en) * 2011-09-30 2013-04-18 Methylgene Inc. Selected Inhibitors of Protein Tyrosine Kinase Activity
ES2593533T3 (es) 2011-12-15 2016-12-09 Pfizer Limited Derivados de sulfonamida
EP3200589B1 (en) 2014-09-10 2026-03-11 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
US20180221365A1 (en) * 2015-05-12 2018-08-09 Temple University-Of The Commonwealth System Of Higher Education Novel sigma-2 receptor binders and their method of use
JP6664170B2 (ja) * 2015-08-31 2020-03-13 広栄化学工業株式会社 アミノヒドロキシピリジン化合物の製造方法
CN108530464B (zh) * 2017-03-02 2020-10-27 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂
CN121108077A (zh) * 2025-09-02 2025-12-12 领泰生物医药(绍兴)有限公司 一种含氮杂环化合物的制备方法及其中间体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020619A1 (en) * 2003-07-24 2005-01-27 Patrick Betschmann Thienopyridine kinase inhibitors
EP1781664B1 (en) * 2004-07-30 2013-09-04 MethylGene Inc. Inhibitors of vegf receptor and hgf receptor signaling
AU2006229343A1 (en) * 2005-03-28 2006-10-05 Kirin Pharma Kabushiki Kaisha Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency
JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
MX2007014617A (es) * 2005-05-20 2008-02-11 Methylgene Inc Inhibidores de senalizacion de receptor de factor de crecimiento endotelial bascular y receptor de factor de crecimiento de hepatocitos.
WO2008041053A2 (en) 2005-05-20 2008-04-10 Methylgene, Inc. Inhibitors of vegf receptor and hgf receptor signaling
EP2183254B1 (en) * 2007-08-29 2017-06-21 MethylGene Inc. Inhibitors of protein tyrosine kinase activity
WO2009026720A1 (en) * 2007-08-29 2009-03-05 Methylgene Inc. Processes and intermediates for preparing fused heterocyclic kinase inhibitors
MX2010009729A (es) * 2008-03-05 2010-12-21 Methylgene Inc Inhibidores de actividad de proteina tirosina quinasa.
MX2012012031A (es) * 2010-04-16 2012-12-17 Methylgene Inc Inhibidores de la actividad de la proteina tirosina quinasa y uso de los mismos para tratar transtornos oftalmicos.
WO2013044361A1 (en) * 2011-09-30 2013-04-04 Methylgene Inc. Inhibitors of protein tyrosine kinase activity

Also Published As

Publication number Publication date
AU2011241422A1 (en) 2012-11-01
US20110257100A1 (en) 2011-10-20
KR20130058006A (ko) 2013-06-03
JP2013525286A (ja) 2013-06-20
MX2012012032A (es) 2012-12-17
AR080875A1 (es) 2012-05-16
US8455484B2 (en) 2013-06-04
AR080871A1 (es) 2012-05-16
UA108878C2 (ru) 2015-06-25
US20110257175A1 (en) 2011-10-20
CA2796008A1 (en) 2011-10-20
EP2563794A1 (en) 2013-03-06
PH12012502073A1 (en) 2013-02-11
AU2011241420B2 (en) 2015-04-16
SG184883A1 (en) 2012-11-29
AU2011241422B2 (en) 2015-05-07
CN102947315A (zh) 2013-02-27
WO2011127567A1 (en) 2011-10-20
ZA201207482B (en) 2013-09-25
US20140315801A1 (en) 2014-10-23
NZ602948A (en) 2014-09-26
EP2563795A1 (en) 2013-03-06
JP2013523846A (ja) 2013-06-17
EP2563794A4 (en) 2013-12-04
CA2796054A1 (en) 2011-10-20
KR20130100234A (ko) 2013-09-10
MY157319A (en) 2016-05-31
MX2012012031A (es) 2012-12-17
WO2011127565A1 (en) 2011-10-20
US8906852B2 (en) 2014-12-09
CN103025740A (zh) 2013-04-03
ZA201207557B (en) 2013-06-26
CO6630193A2 (es) 2013-03-01
TW201204734A (en) 2012-02-01
PH12012502070A1 (en) 2015-05-08
CN103025740B (zh) 2015-07-01
SG184882A1 (en) 2012-11-29
TW201204735A (en) 2012-02-01
EP2563795A4 (en) 2013-10-23
CO6640224A2 (es) 2013-03-22
NZ602954A (en) 2014-11-28
EA201291055A1 (ru) 2013-09-30

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