EA201270519A1 - Гидрофильная фильтрация во время получения адъювантов вакцин - Google Patents

Гидрофильная фильтрация во время получения адъювантов вакцин

Info

Publication number
EA201270519A1
EA201270519A1 EA201270519A EA201270519A EA201270519A1 EA 201270519 A1 EA201270519 A1 EA 201270519A1 EA 201270519 A EA201270519 A EA 201270519A EA 201270519 A EA201270519 A EA 201270519A EA 201270519 A1 EA201270519 A1 EA 201270519A1
Authority
EA
Eurasian Patent Office
Prior art keywords
adjuvants
hydrophil
vaccin
receiving
emulsion
Prior art date
Application number
EA201270519A
Other languages
English (en)
Other versions
EA025622B1 (ru
Inventor
Готтфрид Краус
Роберт Эскес
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43971135&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201270519(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201270519A1 publication Critical patent/EA201270519A1/ru
Publication of EA025622B1 publication Critical patent/EA025622B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
    • B01F27/2711—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with intermeshing elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)

Abstract

Усовершенствованный способ получения эмульсии масло-в-воде включает три процедуры: (i) получение предварительной эмульсии; (ii) микрофлюидизацию предварительной эмульсии для уменьшения размера частичек и (iii) фильтрацию микрофлюидизированной эмульсии через гидрофильную мембрану. Эмульсии могут использоваться в качестве вакцинных адъювантов.
EA201270519A 2009-12-03 2010-12-03 Способ получения содержащей сквален эмульсии масла EA025622B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28351709P 2009-12-03 2009-12-03
PCT/IB2010/003273 WO2011067669A2 (en) 2009-12-03 2010-12-03 Hydrophilic filtration during manufacture of vaccine adjuvants

Publications (2)

Publication Number Publication Date
EA201270519A1 true EA201270519A1 (ru) 2012-12-28
EA025622B1 EA025622B1 (ru) 2017-01-30

Family

ID=43971135

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270519A EA025622B1 (ru) 2009-12-03 2010-12-03 Способ получения содержащей сквален эмульсии масла

Country Status (22)

Country Link
US (3) US10213383B2 (ru)
EP (3) EP2601933B1 (ru)
JP (2) JP5754860B2 (ru)
KR (2) KR101625623B1 (ru)
CN (2) CN104688687A (ru)
AU (1) AU2010325748B2 (ru)
BR (1) BR112012013425A2 (ru)
CA (1) CA2780425C (ru)
CL (1) CL2012001268A1 (ru)
DK (1) DK2343052T3 (ru)
EA (1) EA025622B1 (ru)
ES (3) ES2426969T3 (ru)
HK (2) HK1159995A1 (ru)
HR (1) HRP20130623T1 (ru)
IL (1) IL219627B (ru)
MX (1) MX2012005598A (ru)
NZ (1) NZ599881A (ru)
PL (1) PL2343052T3 (ru)
PT (1) PT2343052E (ru)
SG (1) SG10201501612RA (ru)
SI (2) SI2506832T1 (ru)
WO (1) WO2011067669A2 (ru)

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Also Published As

Publication number Publication date
KR20150041812A (ko) 2015-04-17
ES2426969T3 (es) 2013-10-28
CA2780425A1 (en) 2011-06-09
IL219627A0 (en) 2012-07-31
JP2015098499A (ja) 2015-05-28
IL219627B (en) 2018-05-31
US10799454B2 (en) 2020-10-13
SG10201501612RA (en) 2015-04-29
SI2601933T1 (sl) 2015-12-31
CN102858322B (zh) 2015-04-29
WO2011067669A2 (en) 2011-06-09
KR101625623B1 (ko) 2016-05-31
JP2013512890A (ja) 2013-04-18
CL2012001268A1 (es) 2012-08-03
DK2343052T3 (da) 2013-09-02
PT2343052E (pt) 2013-08-28
ES2461852T3 (es) 2014-05-21
AU2010325748B2 (en) 2014-04-17
KR101616735B1 (ko) 2016-04-29
CN102858322A (zh) 2013-01-02
MX2012005598A (es) 2012-05-29
EP2601933B1 (en) 2015-10-07
JP5754860B2 (ja) 2015-07-29
KR20120101652A (ko) 2012-09-14
EP2506832A2 (en) 2012-10-10
EP2506832B1 (en) 2014-02-26
CA2780425C (en) 2014-02-04
AU2010325748A1 (en) 2012-05-31
US20130129786A1 (en) 2013-05-23
ES2558056T3 (es) 2016-02-01
WO2011067669A3 (en) 2011-08-04
US20190201337A1 (en) 2019-07-04
EP2343052A1 (en) 2011-07-13
EP2343052B1 (en) 2013-06-12
US10213383B2 (en) 2019-02-26
HK1159995A1 (en) 2012-08-10
CN104688687A (zh) 2015-06-10
SI2506832T1 (sl) 2014-06-30
EA025622B1 (ru) 2017-01-30
EP2601933A1 (en) 2013-06-12
HRP20130623T1 (en) 2013-09-30
US20210077395A1 (en) 2021-03-18
NZ599881A (en) 2014-01-31
BR112012013425A2 (pt) 2020-11-03
HK1175407A1 (en) 2013-07-05
PL2343052T3 (pl) 2013-11-29

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