EA201200820A1 - Способ синтеза промежуточных продуктов, применимых для получения замещенных индазолов и азаиндазолов - Google Patents

Способ синтеза промежуточных продуктов, применимых для получения замещенных индазолов и азаиндазолов

Info

Publication number
EA201200820A1
EA201200820A1 EA201200820A EA201200820A EA201200820A1 EA 201200820 A1 EA201200820 A1 EA 201200820A1 EA 201200820 A EA201200820 A EA 201200820A EA 201200820 A EA201200820 A EA 201200820A EA 201200820 A1 EA201200820 A1 EA 201200820A1
Authority
EA
Eurasian Patent Office
Prior art keywords
azaindazoles
synthesis
intermediate products
substituted indazoles
obtaining substituted
Prior art date
Application number
EA201200820A
Other languages
English (en)
Russian (ru)
Inventor
Хоссейн Разави
Джонатан Тимоти Ривс
Сония Родригес
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201200820A1 publication Critical patent/EA201200820A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
EA201200820A 2009-12-08 2010-12-01 Способ синтеза промежуточных продуктов, применимых для получения замещенных индазолов и азаиндазолов EA201200820A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26753809P 2009-12-08 2009-12-08
PCT/US2010/058594 WO2011071730A1 (en) 2009-12-08 2010-12-01 Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds

Publications (1)

Publication Number Publication Date
EA201200820A1 true EA201200820A1 (ru) 2013-01-30

Family

ID=43416915

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200820A EA201200820A1 (ru) 2009-12-08 2010-12-01 Способ синтеза промежуточных продуктов, применимых для получения замещенных индазолов и азаиндазолов

Country Status (17)

Country Link
US (1) US20110137042A1 (enEXAMPLES)
EP (1) EP2509952A1 (enEXAMPLES)
JP (1) JP2013512954A (enEXAMPLES)
KR (1) KR20120101667A (enEXAMPLES)
CN (1) CN102596908A (enEXAMPLES)
AR (1) AR079324A1 (enEXAMPLES)
AU (1) AU2010328480A1 (enEXAMPLES)
BR (1) BR112012013582A2 (enEXAMPLES)
CA (1) CA2782384A1 (enEXAMPLES)
CL (1) CL2012001300A1 (enEXAMPLES)
EA (1) EA201200820A1 (enEXAMPLES)
IL (1) IL219274A0 (enEXAMPLES)
IN (1) IN2012DN05081A (enEXAMPLES)
MX (1) MX2012006524A (enEXAMPLES)
PH (1) PH12012501153A1 (enEXAMPLES)
TW (1) TW201144282A (enEXAMPLES)
WO (1) WO2011071730A1 (enEXAMPLES)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008327B2 (en) 2008-04-29 2011-08-30 Boehringer Ingelheim International Gmbh Indazole compounds as CCR1 receptor antagonists
CA2722811C (en) * 2008-05-06 2016-07-05 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
AP2739A (en) 2008-09-26 2013-09-30 Boehringer Ingelheim Int Azaindazole compounds as CCRI receptor antagonists
EA021015B1 (ru) 2009-10-21 2015-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Индазолы и пиразолопиридины в качестве антагонистов рецептора ccr1
US8927550B2 (en) 2009-10-27 2015-01-06 Boehringer Ingelheim International Gmbh Heterocyclic compounds as CCR1 receptor antagonists
EP2563787B1 (en) 2010-04-30 2014-11-26 Boehringer Ingelheim International GmbH Azaindazole amide compounds as ccr1 receptor antagonists
US8546442B2 (en) 2010-12-23 2013-10-01 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as CCR1 receptor antagonists

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US8008327B2 (en) * 2008-04-29 2011-08-30 Boehringer Ingelheim International Gmbh Indazole compounds as CCR1 receptor antagonists
CA2722811C (en) * 2008-05-06 2016-07-05 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
AP2739A (en) * 2008-09-26 2013-09-30 Boehringer Ingelheim Int Azaindazole compounds as CCRI receptor antagonists

Also Published As

Publication number Publication date
CL2012001300A1 (es) 2012-09-07
AU2010328480A1 (en) 2012-05-17
EP2509952A1 (en) 2012-10-17
AR079324A1 (es) 2012-01-18
BR112012013582A2 (pt) 2016-07-05
CA2782384A1 (en) 2011-06-16
WO2011071730A1 (en) 2011-06-16
IL219274A0 (en) 2012-06-28
CN102596908A (zh) 2012-07-18
US20110137042A1 (en) 2011-06-09
IN2012DN05081A (enEXAMPLES) 2015-10-09
PH12012501153A1 (en) 2012-10-22
TW201144282A (en) 2011-12-16
MX2012006524A (es) 2012-07-17
JP2013512954A (ja) 2013-04-18
KR20120101667A (ko) 2012-09-14

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