EA201100501A1 - Соли n-[6-(цис-2,6-диметилморфолин-4-ил)пиридин-3-ил]-2-метил-4'-(трифторметокси)[1,1'-дифенил]-3-карбоксамида - Google Patents

Соли n-[6-(цис-2,6-диметилморфолин-4-ил)пиридин-3-ил]-2-метил-4'-(трифторметокси)[1,1'-дифенил]-3-карбоксамида

Info

Publication number
EA201100501A1
EA201100501A1 EA201100501A EA201100501A EA201100501A1 EA 201100501 A1 EA201100501 A1 EA 201100501A1 EA 201100501 A EA201100501 A EA 201100501A EA 201100501 A EA201100501 A EA 201100501A EA 201100501 A1 EA201100501 A1 EA 201100501A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carboxamide
pyridin
cis
methyl
triftormetocyl
Prior art date
Application number
EA201100501A
Other languages
English (en)
Other versions
EA020048B1 (ru
Inventor
Джоуджиндер Сингх Баджва
Марилин Де Ла Крус
Стефани Кей Додд
Лиладхар Мурлидхар Уэйкоул
Раинн Ву
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41228716&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201100501(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201100501A1 publication Critical patent/EA201100501A1/ru
Publication of EA020048B1 publication Critical patent/EA020048B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

В заявке описано получение и приведены характеристики солей N-[6-(цис-2,6-диметилморфолин-4-ил)пиридин-3-ил]-2-метил-4'-(трифторметокси)[1,1'-дифенил]-3-карбоксамида.
EA201100501A 2008-09-17 2009-09-15 Дифосфатная соль n-[6-(цис-2,6-диметилморфолин-4-ил)пиридин-3-ил]-2-метил-4'-(трифторметокси)[1,1'-дифенил]-3-карбоксамида и фармацевтическая композиция EA020048B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9758008P 2008-09-17 2008-09-17
PCT/US2009/056918 WO2010033481A1 (en) 2008-09-17 2009-09-15 Salts of n-[6-cis-2,6-dimethylmorpholin-4yl)pyridine-3yl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide

Publications (2)

Publication Number Publication Date
EA201100501A1 true EA201100501A1 (ru) 2011-10-31
EA020048B1 EA020048B1 (ru) 2014-08-29

Family

ID=41228716

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100501A EA020048B1 (ru) 2008-09-17 2009-09-15 Дифосфатная соль n-[6-(цис-2,6-диметилморфолин-4-ил)пиридин-3-ил]-2-метил-4'-(трифторметокси)[1,1'-дифенил]-3-карбоксамида и фармацевтическая композиция

Country Status (39)

Country Link
US (3) US8063043B2 (ru)
EP (1) EP2342198B1 (ru)
JP (2) JP4897938B2 (ru)
KR (2) KR20120015363A (ru)
CN (1) CN102159570B (ru)
AR (2) AR073591A1 (ru)
AU (1) AU2009293444B2 (ru)
BR (2) BRPI0918629B8 (ru)
CA (1) CA2736751C (ru)
CL (1) CL2011000551A1 (ru)
CO (1) CO6351744A2 (ru)
CR (1) CR20110126A (ru)
CU (1) CU23860B1 (ru)
DK (1) DK2342198T3 (ru)
DO (1) DOP2011000082A (ru)
EA (1) EA020048B1 (ru)
EC (1) ECSP11010985A (ru)
ES (1) ES2418485T3 (ru)
GE (1) GEP20125592B (ru)
HK (1) HK1156628A1 (ru)
HN (1) HN2011000745A (ru)
HR (1) HRP20130597T1 (ru)
IL (1) IL211412A (ru)
JO (1) JO2889B1 (ru)
MA (1) MA32717B1 (ru)
MX (1) MX2011002805A (ru)
MY (1) MY151100A (ru)
NI (1) NI201100051A (ru)
NZ (1) NZ591420A (ru)
PE (1) PE20110292A1 (ru)
PL (1) PL2342198T3 (ru)
PT (1) PT2342198E (ru)
SI (1) SI2342198T1 (ru)
SM (1) SMT201300072B (ru)
SV (1) SV2011003857A (ru)
TW (1) TWI367883B (ru)
UA (1) UA103049C2 (ru)
WO (1) WO2010033481A1 (ru)
ZA (1) ZA201101579B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
CN101993415B (zh) * 2010-09-15 2013-08-14 北京韩美药品有限公司 作为Hedgehog通路抑制剂的化合物以及包含该化合物的药物组合物及其应用
WO2014128661A1 (en) 2013-02-25 2014-08-28 Novartis Ag Oral formulation and suspension of an oncology drug
WO2015092720A1 (en) * 2013-12-19 2015-06-25 Novartis Ag Metabolites of sonidegib (lde225)
EP3279198B1 (en) * 2015-03-30 2020-01-01 Crystal Pharmatech Co., Ltd Crystal form of n-[6-(cis form-2,6-dimethylmorpholine-4-group)pyridine-3- group]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3- formamide monophosphate, and preparation method therefor
WO2016196928A1 (en) 2015-06-04 2016-12-08 PellePharm, Inc. Topical formulations for delivery of hedgehog inhibitor compounds and use thereof
KR102511024B1 (ko) 2016-03-15 2023-03-16 오리존 지노믹스 에스.에이. 고형 종양의 치료에 사용하기 위한 lsd1 억제제의 조합물
WO2017163258A1 (en) * 2016-03-22 2017-09-28 Msn Laboratories Private Limited Process for the preparation of n-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2- methyl-4'-(trifiuoromethoxy) [1,1' -biphenyi]-3-carboxamide and its polymorphs thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060058728A (ko) * 2003-10-02 2006-05-30 파마시아 앤드 업존 캄파니 엘엘씨 피롤-치환된 인돌리논 화합물의 염 및 다형체
GB0412468D0 (en) * 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
UA93548C2 (ru) 2006-05-05 2011-02-25 Айерем Елелсі Соединения и композиции kak модуляторы хеджхоговского сигнального пути
PE20080948A1 (es) * 2006-07-25 2008-09-10 Irm Llc Derivados de imidazol como moduladores de la senda de hedgehog

Also Published As

Publication number Publication date
KR101129088B1 (ko) 2012-03-23
JP4897938B2 (ja) 2012-03-14
HK1156628A1 (ru) 2012-06-15
DOP2011000082A (es) 2011-04-15
US20110178085A1 (en) 2011-07-21
CU23860B1 (es) 2013-02-26
AU2009293444B2 (en) 2012-03-15
CL2011000551A1 (es) 2011-07-15
HRP20130597T1 (en) 2013-07-31
EP2342198B1 (en) 2013-04-03
US20120035174A1 (en) 2012-02-09
CA2736751A1 (en) 2010-03-25
KR20120015363A (ko) 2012-02-21
MA32717B1 (fr) 2011-10-02
BRPI0918629A2 (pt) 2020-10-27
CN102159570B (zh) 2014-01-15
EP2342198A1 (en) 2011-07-13
TW201016686A (en) 2010-05-01
IL211412A (en) 2014-07-31
IL211412A0 (en) 2011-05-31
US20120214810A1 (en) 2012-08-23
JO2889B1 (en) 2015-03-15
AR113778A2 (es) 2020-06-10
GEP20125592B (en) 2012-07-25
CR20110126A (es) 2011-04-27
CA2736751C (en) 2012-10-23
TWI367883B (en) 2012-07-11
BRPI0918629B8 (pt) 2021-05-25
BR122020009045B1 (pt) 2022-08-02
SV2011003857A (es) 2011-05-16
NI201100051A (es) 2011-09-08
WO2010033481A1 (en) 2010-03-25
US8063043B2 (en) 2011-11-22
BR122020009045A2 (pt) 2020-11-10
CN102159570A (zh) 2011-08-17
UA103049C2 (ru) 2013-09-10
PT2342198E (pt) 2013-07-10
AU2009293444A1 (en) 2010-03-25
AR073591A1 (es) 2010-11-17
CO6351744A2 (es) 2011-12-20
NZ591420A (en) 2012-07-27
PE20110292A1 (es) 2011-05-17
SMT201300072B (it) 2013-09-06
JP2012502912A (ja) 2012-02-02
DK2342198T3 (da) 2013-07-01
HN2011000745A (es) 2014-01-06
ECSP11010985A (es) 2011-05-31
PL2342198T3 (pl) 2013-08-30
SI2342198T1 (sl) 2013-07-31
ES2418485T3 (es) 2013-08-14
BRPI0918629B1 (pt) 2021-04-13
CU20110055A7 (es) 2011-12-28
JP2012097104A (ja) 2012-05-24
MY151100A (en) 2014-04-15
EA020048B1 (ru) 2014-08-29
MX2011002805A (es) 2011-04-11
KR20110056325A (ko) 2011-05-26
ZA201101579B (en) 2011-11-30

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KG TJ TM

PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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