EA201070966A1 - Фолаты, композиции и применение указанных композиций - Google Patents

Фолаты, композиции и применение указанных композиций

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Publication number
EA201070966A1
EA201070966A1 EA201070966A EA201070966A EA201070966A1 EA 201070966 A1 EA201070966 A1 EA 201070966A1 EA 201070966 A EA201070966 A EA 201070966A EA 201070966 A EA201070966 A EA 201070966A EA 201070966 A1 EA201070966 A1 EA 201070966A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
folates
applications
indicated
well
Prior art date
Application number
EA201070966A
Other languages
English (en)
Other versions
EA017742B1 (ru
Inventor
Эрманно Валоти
Давиде Бьянки
Марко Валетти
Original Assignee
Ньосис С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ньосис С.П.А. filed Critical Ньосис С.П.А.
Publication of EA201070966A1 publication Critical patent/EA201070966A1/ru
Publication of EA017742B1 publication Critical patent/EA017742B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

Настоящее изобретение касается фолатов, композиций и применения указанных композиций; в частности, настоящее изобретение описывает кристаллические и аморфные соединения, являющиеся замещенными или незамещенными фолатами, или восстановленными фолатами либо природными или неприродными изомерами по меньшей мере одного органического основания, а также композиции и применение указанных композиций. Соединения по изобретению обладают длительной стабильностью, а также особенно высокой водорастворимостью.
EA201070966A 2008-02-20 2008-02-20 Фолаты, композиции и применение указанных композиций EA017742B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2008/052037 WO2009103334A1 (en) 2008-02-20 2008-02-20 Folates, compositions and uses thereof

Publications (2)

Publication Number Publication Date
EA201070966A1 true EA201070966A1 (ru) 2011-02-28
EA017742B1 EA017742B1 (ru) 2013-02-28

Family

ID=40299393

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070966A EA017742B1 (ru) 2008-02-20 2008-02-20 Фолаты, композиции и применение указанных композиций

Country Status (22)

Country Link
EP (1) EP2245032B1 (ru)
JP (1) JP5856372B2 (ru)
KR (1) KR101512624B1 (ru)
CN (1) CN101970439B (ru)
AU (1) AU2008351242B2 (ru)
BR (1) BRPI0822337B8 (ru)
CA (1) CA2712714C (ru)
CY (1) CY1116343T1 (ru)
DK (1) DK2245032T3 (ru)
EA (1) EA017742B1 (ru)
ES (1) ES2538480T3 (ru)
HR (1) HRP20150674T1 (ru)
HU (1) HUE025450T2 (ru)
IL (1) IL207164A (ru)
MX (1) MX2010009075A (ru)
NZ (1) NZ586959A (ru)
PL (1) PL2245032T3 (ru)
PT (1) PT2245032E (ru)
SI (1) SI2245032T1 (ru)
UA (1) UA103310C2 (ru)
WO (1) WO2009103334A1 (ru)
ZA (1) ZA201005278B (ru)

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* Cited by examiner, † Cited by third party
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CN103450202B (zh) * 2012-06-04 2015-07-01 南京莱因医药科技有限公司 L-5-甲基四氢叶酸与有机碱加成盐的方法
CN103664945B (zh) * 2012-09-07 2016-01-20 南京莱因医药科技有限公司 L-5-甲基四氢叶酸氨基酸盐的制备方法
JP2015024965A (ja) * 2013-07-24 2015-02-05 株式会社えがお グルコサミン有機酸抱合物およびその製造方法
TWI782445B (zh) * 2014-05-30 2022-11-01 美商嘉康利公司 夏多內葡萄籽萃取物
EP3190112A4 (en) 2014-09-04 2017-09-13 Lianyungang Jinkang Hexin Pharmaceutical Co., Ltd. Composition of (6s)-5-methyl tetrahydrofolic acid or salt thereof as well as preparation therefor and application thereof
CN106901379B (zh) * 2017-03-11 2021-08-13 深圳奥萨制药有限公司 一种辅助预防心血管疾病的维生素保健食品
CN106974292B (zh) * 2017-03-22 2021-02-26 深圳奥萨制药有限公司 一种由维生素d、e及叶酸组成的维生素组合物保健食品
EP3609895B1 (en) 2017-03-31 2024-10-16 Merck Patent GmbH Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid
AU2018246265B2 (en) 2017-03-31 2022-07-07 Merck Patent Gmbh Crystalline sodium salt of 5-methyl-(6S)-tetrahydrofolic acid
EP3461826A1 (en) * 2017-09-29 2019-04-03 Aprofol AG Multifunctional folate salts
EP3586849A1 (en) * 2018-06-29 2020-01-01 Aprofol AG Folate preparations
JP7532336B2 (ja) * 2018-07-06 2024-08-13 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ５－メチル（６ｓ）－テトラヒドロ葉酸および４－（２－ヒドロキシエチル）－モルホリンを含む結晶塩
PT3817812T (pt) * 2018-07-06 2023-12-28 Merck Patent Gmbh Sal cristalino de acido 5-metil-(68)-tetra-hidrofólico e éster etílico de l-isoleucina
EP3646873A1 (en) 2018-10-31 2020-05-06 Aprofol AG Folate salts
CN109748920A (zh) * 2018-12-24 2019-05-14 中健(广州)生物医药研究院有限公司 一种l-5-甲基四氢叶酸氨基葡萄糖盐及其合成方法
CN110313568A (zh) * 2018-12-24 2019-10-11 中健(广州)生物医药研究院有限公司 一种叶酸增强益生菌型固体饮料及其制备方法
CN110302090A (zh) * 2018-12-24 2019-10-08 中健(广州)生物医药研究院有限公司 L-5-甲基四氢叶酸氨基葡萄糖盐在化妆品中的应用
CN110974917A (zh) * 2019-11-25 2020-04-10 垒途智能教科技术研究院江苏有限公司 一种具有辅助防治儿童、青少年心理抑郁的作用的复合制剂
CN115040489B (zh) * 2022-08-17 2022-10-25 北京罗诺强施医药技术研发中心有限公司 具有优良一致性的稳定药物组合物及其制法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2137186A1 (en) * 1971-05-14 1972-12-29 Mauvernay Centre Europ Folic acid salts - used as neuro-stimulants and for dynamising muscular function
JPS57123140A (en) * 1981-01-23 1982-07-31 Sankyo Co Ltd Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component
IT1195288B (it) * 1981-11-05 1988-10-12 Zambeletti Spa L Composizione farmaceutica per la terapia di calcolosi renale infetta
CA2021042A1 (en) * 1989-07-21 1991-01-22 Fabrizio Marazza Salts of n ,n -methylene-5,6,7,8-tetrahydrofolic acid
IT1245889B (it) * 1991-04-12 1994-10-25 Alfa Wassermann Spa Formulazioni farmaceutiche per uso orale gastroresistenti contenenti sali di acidi biliari.
CH689831A5 (de) * 1995-11-07 1999-12-15 Eprova Ag Stabile kristalline Tetrahydrofolsaeure-Salze.
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
JPWO2005112667A1 (ja) * 2004-05-20 2008-03-27 隆史 大森 健康食品
JP2006131611A (ja) * 2004-10-07 2006-05-25 Otsuka Pharmaceut Factory Inc 骨代謝・たんぱく質代謝改善用栄養組成物

Also Published As

Publication number Publication date
ES2538480T3 (es) 2015-06-22
BRPI0822337B1 (pt) 2019-02-12
JP2011512366A (ja) 2011-04-21
AU2008351242B2 (en) 2012-12-20
BRPI0822337A2 (pt) 2015-06-16
IL207164A (en) 2015-01-29
ZA201005278B (en) 2011-09-28
JP5856372B2 (ja) 2016-02-09
AU2008351242A1 (en) 2009-08-27
IL207164A0 (en) 2010-12-30
MX2010009075A (es) 2010-11-26
PT2245032E (pt) 2015-07-21
EP2245032A1 (en) 2010-11-03
DK2245032T3 (da) 2015-06-22
SI2245032T1 (sl) 2015-08-31
HRP20150674T1 (hr) 2015-07-31
BRPI0822337B8 (pt) 2021-05-25
UA103310C2 (en) 2013-10-10
CN101970439A (zh) 2011-02-09
EA017742B1 (ru) 2013-02-28
HUE025450T2 (en) 2016-04-28
CY1116343T1 (el) 2017-02-08
EP2245032B1 (en) 2015-03-25
WO2009103334A1 (en) 2009-08-27
NZ586959A (en) 2012-04-27
CN101970439B (zh) 2014-11-12
PL2245032T3 (pl) 2015-08-31
KR20110011602A (ko) 2011-02-08
CA2712714A1 (en) 2009-08-27
KR101512624B1 (ko) 2015-04-16
CA2712714C (en) 2015-05-12
AU2008351242A2 (en) 2010-09-09

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM