EA201070887A1 - Применение 4'-тио-2'-диоксинуклеозидов в качестве противо-ортопоксвирусных средств - Google Patents

Применение 4'-тио-2'-диоксинуклеозидов в качестве противо-ортопоксвирусных средств

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Publication number
EA201070887A1
EA201070887A1 EA201070887A EA201070887A EA201070887A1 EA 201070887 A1 EA201070887 A1 EA 201070887A1 EA 201070887 A EA201070887 A EA 201070887A EA 201070887 A EA201070887 A EA 201070887A EA 201070887 A1 EA201070887 A1 EA 201070887A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
orthox
dioxinucleosides
tio
application
Prior art date
Application number
EA201070887A
Other languages
English (en)
Other versions
EA017705B1 (ru
Inventor
Джон А Секрист III
Камаль Н Тивари
Джозеф А Маддри
Original Assignee
Саузерн Рисерч Инститьют
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Саузерн Рисерч Инститьют filed Critical Саузерн Рисерч Инститьют
Publication of EA201070887A1 publication Critical patent/EA201070887A1/ru
Publication of EA017705B1 publication Critical patent/EA017705B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Применение соединения, представленного формуламигде каждый R по отдельности представляет собой Н или алифатическую ацильную или ароматическую ацильную группу; Х выбран из группы, включающей водород, фтор, бром, йод, алкокси-, алкил-, галоаклкил-, алкенил-, галоалкенил-, алкинил-, амино-, моноалкиламино-, диалкиламино, циано-, арил- и нитрогруппы; фармацевтически приемлемые соли указанного соединения, пролекарство указанного соединения и смеси указанного соединения; в качестве подавителей ортопоксвирусной инфекции и для лечения пациентов, страдающих от ортопоксвирусной инфекции, такой как, но не ограничивающейся указанными, оспа, коровья оспа, обезьянья оспа и верблюжья оспа.
EA201070887A 2008-03-12 2009-03-12 Способ подавления ортопоксвирусных инфекций EA017705B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/047,197 US8859589B2 (en) 2008-03-12 2008-03-12 Use of 4′-thio-2′-deoxynucleosides as anti orthopoxvirus agents
PCT/US2009/036869 WO2009114651A2 (en) 2008-03-12 2009-03-12 Use of '-thio-2'-deoxynucleosides as anri orthopoxvirus agents

Publications (2)

Publication Number Publication Date
EA201070887A1 true EA201070887A1 (ru) 2011-06-30
EA017705B1 EA017705B1 (ru) 2013-02-28

Family

ID=41065824

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070887A EA017705B1 (ru) 2008-03-12 2009-03-12 Способ подавления ортопоксвирусных инфекций

Country Status (12)

Country Link
US (1) US8859589B2 (ru)
EP (1) EP2262365B1 (ru)
JP (1) JP5543930B2 (ru)
KR (1) KR20100132503A (ru)
CN (1) CN101959407A (ru)
AU (1) AU2009223064B8 (ru)
BR (1) BRPI0909840A2 (ru)
CA (1) CA2718175C (ru)
EA (1) EA017705B1 (ru)
MX (1) MX2010010082A (ru)
NZ (1) NZ587915A (ru)
WO (1) WO2009114651A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104203969B (zh) 2012-03-28 2016-08-31 富士胶片株式会社 1-(2-脱氧-2-氟-4-硫代-β-D-阿拉伯呋喃糖基)胞嘧啶的盐
KR20170001722A (ko) 2012-08-13 2017-01-04 후지필름 가부시키가이샤 1-(2-데옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 합성 중간체, 티오뉴클레오시드의 합성 중간체, 및 그들의 제조법
WO2015125781A1 (ja) 2014-02-18 2015-08-27 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
SG11201901815WA (en) 2016-08-31 2019-04-29 Fujifilm Corp Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit
CA3089728C (en) 2018-01-29 2023-01-10 Fujifilm Corporation Antitumor agent for biliary tract cancer and method for treating biliary tract cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591722A (en) * 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
IE74701B1 (en) 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
US20050053626A1 (en) * 2003-09-05 2005-03-10 Harrington John Ames Grace process biotechnology patent the cure to the herpes virus
EP2842559A3 (en) 2005-04-08 2015-03-18 Chimerix, Inc. Compounds, compositions and methods for the treatment of viral infections and other medical disorders

Also Published As

Publication number Publication date
AU2009223064B8 (en) 2014-01-16
EA017705B1 (ru) 2013-02-28
US20120136017A1 (en) 2012-05-31
AU2009223064B2 (en) 2013-08-29
AU2009223064A1 (en) 2009-09-17
JP5543930B2 (ja) 2014-07-09
US8859589B2 (en) 2014-10-14
BRPI0909840A2 (pt) 2015-07-28
NZ587915A (en) 2012-02-24
JP2011526242A (ja) 2011-10-06
EP2262365A2 (en) 2010-12-22
CA2718175C (en) 2016-06-28
MX2010010082A (es) 2011-06-01
WO2009114651A2 (en) 2009-09-17
WO2009114651A3 (en) 2010-03-18
EP2262365A4 (en) 2011-06-29
EP2262365B1 (en) 2016-11-16
CA2718175A1 (en) 2009-09-17
KR20100132503A (ko) 2010-12-17
WO2009114651A8 (en) 2009-12-03
CN101959407A (zh) 2011-01-26

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU