EA201000903A1 - Антитела к pcrv-антигену pseudomonas aeruginosa - Google Patents
Антитела к pcrv-антигену pseudomonas aeruginosaInfo
- Publication number
- EA201000903A1 EA201000903A1 EA201000903A EA201000903A EA201000903A1 EA 201000903 A1 EA201000903 A1 EA 201000903A1 EA 201000903 A EA201000903 A EA 201000903A EA 201000903 A EA201000903 A EA 201000903A EA 201000903 A1 EA201000903 A1 EA 201000903A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pseudomonas aeruginosa
- pcrv
- antitel
- antigen
- administered
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Gram-negative bacteria
- C07K16/1214—Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99167907P | 2007-11-30 | 2007-11-30 | |
| PCT/US2008/085196 WO2009073631A2 (en) | 2007-11-30 | 2008-12-01 | Antibodies to the pcrv antigen of pseudomonas aeruginosa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201000903A1 true EA201000903A1 (ru) | 2011-02-28 |
Family
ID=40527381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201000903A EA201000903A1 (ru) | 2007-11-30 | 2008-12-01 | Антитела к pcrv-антигену pseudomonas aeruginosa |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8044181B2 (https=) |
| EP (1) | EP2220117A2 (https=) |
| JP (1) | JP5781765B2 (https=) |
| KR (1) | KR20100097719A (https=) |
| CN (1) | CN101910197B (https=) |
| AU (1) | AU2008333985B2 (https=) |
| BR (1) | BRPI0819598A2 (https=) |
| CA (1) | CA2706732A1 (https=) |
| EA (1) | EA201000903A1 (https=) |
| IL (1) | IL206036A0 (https=) |
| MX (1) | MX2010005871A (https=) |
| NZ (1) | NZ586357A (https=) |
| SG (1) | SG186017A1 (https=) |
| WO (1) | WO2009073631A2 (https=) |
| ZA (1) | ZA201003852B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| BRPI0513826A2 (pt) | 2004-07-26 | 2010-06-22 | Dow Global Technologies Inc | processo para expressão de proteìna melhorada através de engenharia de cepa |
| US9394571B2 (en) * | 2007-04-27 | 2016-07-19 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| US9580719B2 (en) * | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| EA020544B1 (ru) | 2008-01-10 | 2014-12-30 | Шионоги Энд Ко., Лтд. | АНТИТЕЛА ПРОТИВ PcrV |
| CA2751433A1 (en) * | 2009-02-04 | 2010-08-12 | Kalobios Pharmaceuticals, Inc. | Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection |
| SG174225A1 (en) * | 2009-03-11 | 2011-10-28 | Shionogi & Co | Humanized pcrv antibody having anti-pseudomonal activity |
| WO2011087799A1 (en) * | 2009-12-22 | 2011-07-21 | Kalobios Pharmaceuticals, Inc. | A method of treating a staphylococcus infection in a patient having a low-level pathogenic pseudomonas aeruginosa infection |
| WO2012012571A1 (en) | 2010-07-21 | 2012-01-26 | Hans Zassenhaus | Biolayer interferometry measurement of biological targets |
| RU2014100111A (ru) | 2011-06-10 | 2015-07-20 | МЕДИММЬЮН, ЭлЭлСи | МОЛЕКУЛЫ, СВЯЗЫВАЮЩИЕСЯ С Psl Pseudomonas, И ПУТИ ИХ ПРИМЕНЕНИЯ |
| HRP20201370T1 (hr) * | 2011-11-07 | 2020-11-27 | Medimmune Limited | Kombinacijske terapije koje koriste anti-pseudomonas psl i pcrv vezujuće molekule |
| EP2820043B1 (en) | 2012-03-02 | 2020-01-15 | Ablynx N.V. | Biparatopic pseudomonas aeruginosa pcrv binding single variable domain antibodies |
| BR112015010240A2 (pt) * | 2012-11-06 | 2017-08-22 | Medimmune Ltd | Terapias de combinação através do uso de mo-léculas de ligação de psl e de pcrv anti-pseudomonas |
| ES2846881T3 (es) | 2015-05-01 | 2021-07-30 | Inhibrx Inc | Moléculas que se dirigen al sistema de secreción de tipo III |
| CA2991634C (en) | 2015-07-16 | 2026-03-17 | Inhibrx Biosciences, Inc. | Multivalent and multispecific dr5-binding fusion proteins |
| SG11201809778TA (en) | 2016-05-05 | 2018-12-28 | Univ Pennsylvania | Dna antibody constructs for use against pseudomonas aeruginosa |
| EA202091984A1 (ru) | 2018-03-14 | 2021-02-18 | Сиэтл Чилдрен'С Хоспитал (Дба Сиэтл Чилдрен'С Ресёрч Инститьют) | Направленная дзетакинами т-клеточная иммунотерапия, нацеленная на рецептор il-13 альфа 2 |
| MX2021001305A (es) | 2018-08-01 | 2021-06-23 | Cephalon Inc | Anticuerpos anti-cxcr2 y usos de los mismos. |
| EP3983015A1 (en) * | 2019-06-11 | 2022-04-20 | Regeneron Pharmaceuticals, Inc. | Anti-pcrv antibodies that bind pcrv, compositions comprising anti-pcrv antibodies, and methods of use thereof |
| CN118620074A (zh) * | 2020-06-01 | 2024-09-10 | 北京三诺佳邑生物技术有限责任公司 | 特异性识别假单胞菌pcrv的抗体及其用途 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US108565A (en) * | 1870-10-25 | Improvement in snow-plows | ||
| US134098A (en) * | 1872-12-17 | Improvement in gage-cocks | ||
| US225552A (en) * | 1880-03-16 | Disintegrating-mill | ||
| GB8720833D0 (en) | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
| US5219998A (en) * | 1990-06-04 | 1993-06-15 | Levin Robert H | Yeast-derived epidermal growth factor |
| GB9012995D0 (en) * | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
| WO1998002462A1 (en) | 1996-07-16 | 1998-01-22 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Immunoglobulin superfamily domains and fragments with increased solubility |
| US7141393B2 (en) * | 1996-12-26 | 2006-11-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18-receptor proteins |
| EP1666058B1 (en) * | 1998-11-25 | 2011-12-28 | MCW Research Foundation, Incorporated | Method of diagnosing a Pseudomonas aeruginosa infection |
| DE19918418C1 (de) * | 1999-04-23 | 2000-10-19 | Siegfried Mueller | Pflanzvorrichtung mit Halterung |
| WO2001064749A2 (en) * | 2000-02-28 | 2001-09-07 | Idec Pharmaceuticals Corporation | Method for preparing anti-mif antibodies |
| WO2002064161A2 (en) * | 2001-01-26 | 2002-08-22 | Mcw Research Foundation, Inc. | Method and compositions for immunization with the pseudomonas v antigen |
| CA2374027A1 (en) * | 2001-03-13 | 2002-09-13 | The Minister Of National Defence | Cloning, expression, sequencing, and functional enhancement of monoclonal scfv antibody against venezuelan equine encephalitis virus(vee) |
| ATE458006T1 (de) * | 2003-05-14 | 2010-03-15 | Kenta Biotech Ag | Humaner monoklonaler antikörper spezifisch für lipopolysacchariden (lps) des serotyps iats o6 von pseudomonas aeruginosa |
| EP1761561B1 (en) * | 2004-01-20 | 2015-08-26 | KaloBios Pharmaceuticals, Inc. | Antibody specificity transfer using minimal essential binding determinants |
| PT2343380T (pt) * | 2004-11-16 | 2019-09-18 | Humanigen Inc | Permuta de cassetes da região variável de imunoglobulina |
| EP1915394B1 (en) | 2005-05-20 | 2021-01-27 | Lonza Biologics plc. | High-level expression of recombinant antibody in a mammalian host cell |
| EP1726650A1 (en) | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
| CA2613691A1 (en) | 2005-07-05 | 2007-01-11 | Baker Medical Research Institute | Anticoagulation agent and uses thereof |
| EP1987066B1 (en) | 2006-02-22 | 2010-12-29 | University of Zürich | Methods for treating demyelinating diseases |
| US7649083B2 (en) | 2006-06-02 | 2010-01-19 | Aveo Pharmaceuticals, Inc. | Hepatocyte growth factor (HGF) binding antibody |
| EP2386577A3 (en) | 2006-06-21 | 2012-05-02 | Oncotherapy Science, Inc. | Tumor-targeting monoclonal antibodies to FZD10 and uses thereof |
-
2008
- 2008-12-01 BR BRPI0819598A patent/BRPI0819598A2/pt not_active IP Right Cessation
- 2008-12-01 SG SG2012085239A patent/SG186017A1/en unknown
- 2008-12-01 AU AU2008333985A patent/AU2008333985B2/en not_active Ceased
- 2008-12-01 NZ NZ586357A patent/NZ586357A/xx not_active IP Right Cessation
- 2008-12-01 CN CN200880124705.7A patent/CN101910197B/zh not_active Expired - Fee Related
- 2008-12-01 CA CA2706732A patent/CA2706732A1/en active Pending
- 2008-12-01 KR KR1020107014345A patent/KR20100097719A/ko not_active Ceased
- 2008-12-01 EA EA201000903A patent/EA201000903A1/ru unknown
- 2008-12-01 MX MX2010005871A patent/MX2010005871A/es active IP Right Grant
- 2008-12-01 JP JP2010536228A patent/JP5781765B2/ja not_active Expired - Fee Related
- 2008-12-01 EP EP08856948A patent/EP2220117A2/en not_active Ceased
- 2008-12-01 WO PCT/US2008/085196 patent/WO2009073631A2/en not_active Ceased
- 2008-12-01 US US12/325,806 patent/US8044181B2/en not_active Expired - Fee Related
-
2010
- 2010-05-27 IL IL206036A patent/IL206036A0/en unknown
- 2010-05-28 ZA ZA2010/03852A patent/ZA201003852B/en unknown
-
2011
- 2011-10-11 US US13/271,146 patent/US8877191B2/en not_active Expired - Fee Related
-
2014
- 2014-10-08 US US14/509,437 patent/US20150030614A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2220117A2 (en) | 2010-08-25 |
| ZA201003852B (en) | 2014-11-26 |
| SG186017A1 (en) | 2012-12-28 |
| MX2010005871A (es) | 2010-06-09 |
| US20120020986A1 (en) | 2012-01-26 |
| BRPI0819598A2 (pt) | 2017-05-09 |
| AU2008333985A1 (en) | 2009-06-11 |
| WO2009073631A3 (en) | 2009-09-24 |
| JP2011505381A (ja) | 2011-02-24 |
| CA2706732A1 (en) | 2009-06-11 |
| US8877191B2 (en) | 2014-11-04 |
| WO2009073631A2 (en) | 2009-06-11 |
| US20090191186A1 (en) | 2009-07-30 |
| JP5781765B2 (ja) | 2015-09-24 |
| NZ586357A (en) | 2012-10-26 |
| US20150030614A1 (en) | 2015-01-29 |
| KR20100097719A (ko) | 2010-09-03 |
| US8044181B2 (en) | 2011-10-25 |
| AU2008333985B2 (en) | 2015-02-05 |
| CN101910197A (zh) | 2010-12-08 |
| CN101910197B (zh) | 2014-09-24 |
| IL206036A0 (en) | 2010-11-30 |
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