EA200970465A1 - Укороченные пептиды pth циклической конформации - Google Patents

Укороченные пептиды pth циклической конформации

Info

Publication number
EA200970465A1
EA200970465A1 EA200970465A EA200970465A EA200970465A1 EA 200970465 A1 EA200970465 A1 EA 200970465A1 EA 200970465 A EA200970465 A EA 200970465A EA 200970465 A EA200970465 A EA 200970465A EA 200970465 A1 EA200970465 A1 EA 200970465A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pth
cutted
pth peptides
cyclic conformation
peptides
Prior art date
Application number
EA200970465A
Other languages
English (en)
Inventor
Трайн Сковланд Ридж
Мартин Штальхут
Карстен Бойи Кнудсен
Бьярне Дью Ларсен
Original Assignee
Зилэнд Фарма А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зилэнд Фарма А/С filed Critical Зилэнд Фарма А/С
Publication of EA200970465A1 publication Critical patent/EA200970465A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Согласно настоящему изобретению предложены пептиды РТН, представляющие собой циклизованные содержащие замены аналоги РТН(1-17), укороченного фрагмента РТН, которые предпочтительно сохраняет желаемую или близкую биологическую активность РТН (1-34) человека.
EA200970465A 2006-12-08 2007-12-06 Укороченные пептиды pth циклической конформации EA200970465A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87372306P 2006-12-08 2006-12-08
EP06025423A EP1961765A1 (en) 2006-12-08 2006-12-08 Truncated PTH peptides with a cyclic conformation
PCT/GB2007/004664 WO2008068487A1 (en) 2006-12-08 2007-12-06 Truncated pth peptides with a cyclic conformation

Publications (1)

Publication Number Publication Date
EA200970465A1 true EA200970465A1 (ru) 2010-02-26

Family

ID=38230002

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970465A EA200970465A1 (ru) 2006-12-08 2007-12-06 Укороченные пептиды pth циклической конформации

Country Status (12)

Country Link
US (1) US20100048462A1 (ru)
EP (2) EP1961765A1 (ru)
JP (1) JP2010511686A (ru)
KR (1) KR20090096506A (ru)
CN (1) CN101600735A (ru)
AU (1) AU2007330617B2 (ru)
BR (1) BRPI0719874A2 (ru)
CA (1) CA2670950A1 (ru)
EA (1) EA200970465A1 (ru)
MX (1) MX2009005788A (ru)
NZ (1) NZ578227A (ru)
WO (1) WO2008068487A1 (ru)

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EP2411038B1 (en) 2009-03-27 2016-12-28 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
WO2010128521A2 (en) 2009-04-24 2010-11-11 Cadila Healthcare Limited Short-chain peptides as parathyroid hormone (pth) receptor agonist
PL3133070T3 (pl) * 2009-11-27 2020-01-31 Genzyme Corporation Eliglustat (Genz 112638) jako inhibitor syntazy glukozyloceramidowej do zastosowania w sposobie leczenia choroby Fabry’ego lub choroby Gauchera, przy czym sposób obejmuje dostosowanie indywidualnej dawki terapeutycznej do metabolizmu P450 u pacjenta
RU2604809C2 (ru) * 2010-05-13 2016-12-10 Дзе Дженерал Хоспитал Корпорейшн Аналоги паратиреоидного гормона и их применение
US20120184494A1 (en) * 2010-11-12 2012-07-19 Maurizio Zangari Multiple myeloma prognosis and treatment
WO2012120532A2 (en) 2011-02-02 2012-09-13 Cadila Healthcare Limited Cyclic short chain peptides
WO2012158962A2 (en) * 2011-05-18 2012-11-22 Eumederis Pharmaceuticals, Inc. Improved peptide pharmaceuticals
ES2816009T3 (es) * 2011-12-14 2021-03-31 Univ Arkansas Administración de agentes terapéuticos mediante una proteína de unión a colágeno
EP3434696A1 (en) 2012-11-20 2019-01-30 Mederis Diabetes, LLC Improved peptide pharmaceuticals for insulin resistance
CN117180445A (zh) 2014-05-28 2023-12-08 梅德瑞斯糖尿病有限责任公司 针对胰岛素抵抗的改良肽药物
PL3464336T3 (pl) 2016-06-01 2022-05-16 Athira Pharma, Inc. Związki
IL311775A (en) 2018-01-03 2024-05-01 Mederis Diabetes Llc Improved peptide drugs for the treatment of NASH and other disorders
EP3796941A4 (en) * 2018-05-30 2022-12-28 Purdue Research Foundation TARGETING ANABOLIC DRUGS FOR ACCELERATED FRACTURE REPAIR

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Also Published As

Publication number Publication date
CA2670950A1 (en) 2008-06-12
EP1961765A1 (en) 2008-08-27
BRPI0719874A2 (pt) 2014-04-15
CN101600735A (zh) 2009-12-09
AU2007330617A1 (en) 2008-06-12
AU2007330617B2 (en) 2012-11-29
NZ578227A (en) 2011-06-30
US20100048462A1 (en) 2010-02-25
JP2010511686A (ja) 2010-04-15
WO2008068487A1 (en) 2008-06-12
MX2009005788A (es) 2009-06-08
EP2054438A1 (en) 2009-05-06
KR20090096506A (ko) 2009-09-10

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