EA200970465A1 - Укороченные пептиды pth циклической конформации - Google Patents

Укороченные пептиды pth циклической конформации

Info

Publication number
EA200970465A1
EA200970465A1 EA200970465A EA200970465A EA200970465A1 EA 200970465 A1 EA200970465 A1 EA 200970465A1 EA 200970465 A EA200970465 A EA 200970465A EA 200970465 A EA200970465 A EA 200970465A EA 200970465 A1 EA200970465 A1 EA 200970465A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pth
cutted
pth peptides
cyclic conformation
peptides
Prior art date
Application number
EA200970465A
Other languages
English (en)
Inventor
Трайн Сковланд Ридж
Мартин Штальхут
Карстен Бойи Кнудсен
Бьярне Дью Ларсен
Original Assignee
Зилэнд Фарма А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зилэнд Фарма А/С filed Critical Зилэнд Фарма А/С
Publication of EA200970465A1 publication Critical patent/EA200970465A1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Согласно настоящему изобретению предложены пептиды РТН, представляющие собой циклизованные содержащие замены аналоги РТН(1-17), укороченного фрагмента РТН, которые предпочтительно сохраняет желаемую или близкую биологическую активность РТН (1-34) человека.
EA200970465A 2006-12-08 2007-12-06 Укороченные пептиды pth циклической конформации EA200970465A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87372306P 2006-12-08 2006-12-08
EP06025423A EP1961765A1 (en) 2006-12-08 2006-12-08 Truncated PTH peptides with a cyclic conformation
PCT/GB2007/004664 WO2008068487A1 (en) 2006-12-08 2007-12-06 Truncated pth peptides with a cyclic conformation

Publications (1)

Publication Number Publication Date
EA200970465A1 true EA200970465A1 (ru) 2010-02-26

Family

ID=38230002

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970465A EA200970465A1 (ru) 2006-12-08 2007-12-06 Укороченные пептиды pth циклической конформации

Country Status (12)

Country Link
US (1) US20100048462A1 (ru)
EP (2) EP1961765A1 (ru)
JP (1) JP2010511686A (ru)
KR (1) KR20090096506A (ru)
CN (1) CN101600735A (ru)
AU (1) AU2007330617B2 (ru)
BR (1) BRPI0719874A2 (ru)
CA (1) CA2670950A1 (ru)
EA (1) EA200970465A1 (ru)
MX (1) MX2009005788A (ru)
NZ (1) NZ578227A (ru)
WO (1) WO2008068487A1 (ru)

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AU2008282805B2 (en) 2007-08-01 2014-05-01 Chugai Pharmaceutical Co., Ltd. Screening methods using G-protein coupled receptors and related compositions
WO2010111617A2 (en) 2009-03-27 2010-09-30 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
CN102405229A (zh) 2009-04-24 2012-04-04 卡迪拉保健有限公司 作为甲状旁腺激素(pth)受体激动剂的短链肽
HUE029371T2 (en) * 2009-11-27 2017-02-28 Genzyme Corp GENZ 112638 For treatment of Gaucher or Fabry disease in combination therapy
RU2604809C2 (ru) * 2010-05-13 2016-12-10 Дзе Дженерал Хоспитал Корпорейшн Аналоги паратиреоидного гормона и их применение
US20120184494A1 (en) * 2010-11-12 2012-07-19 Maurizio Zangari Multiple myeloma prognosis and treatment
WO2012120532A2 (en) 2011-02-02 2012-09-13 Cadila Healthcare Limited Cyclic short chain peptides
EP2709645B1 (en) * 2011-05-18 2023-08-09 Eumederis Pharmaceuticals, Inc. Improved peptide pharmaceuticals
EP2790717B1 (en) * 2011-12-14 2018-05-30 The Board of Trustees of the University of Arkansas Delivery of therapeutic agents by a collagen binding protein
JP6525456B2 (ja) 2012-11-20 2019-06-05 メデリス ダイアビーティーズ,エルエルシー インスリン抵抗性のための改善されたペプチド製剤
CN117180445A (zh) 2014-05-28 2023-12-08 梅德瑞斯糖尿病有限责任公司 针对胰岛素抵抗的改良肽药物
RS63143B1 (sr) 2016-06-01 2022-05-31 Athira Pharma Inc Jedinjenja
US11541028B2 (en) 2018-01-03 2023-01-03 Altimmune Inc. Peptide pharmaceuticals for treatment of NASH and other disorders
US20210206820A1 (en) * 2018-05-30 2021-07-08 Purdue Research Foundation Targeting anabolic drugs for accelerated fracture repair

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Also Published As

Publication number Publication date
WO2008068487A1 (en) 2008-06-12
EP2054438A1 (en) 2009-05-06
NZ578227A (en) 2011-06-30
CA2670950A1 (en) 2008-06-12
BRPI0719874A2 (pt) 2014-04-15
AU2007330617A1 (en) 2008-06-12
US20100048462A1 (en) 2010-02-25
KR20090096506A (ko) 2009-09-10
MX2009005788A (es) 2009-06-08
EP1961765A1 (en) 2008-08-27
CN101600735A (zh) 2009-12-09
JP2010511686A (ja) 2010-04-15
AU2007330617B2 (en) 2012-11-29

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