EA200970121A1 - Производные хиназолина в качестве mtki - Google Patents

Производные хиназолина в качестве mtki

Info

Publication number
EA200970121A1
EA200970121A1 EA200970121A EA200970121A EA200970121A1 EA 200970121 A1 EA200970121 A1 EA 200970121A1 EA 200970121 A EA200970121 A EA 200970121A EA 200970121 A EA200970121 A EA 200970121A EA 200970121 A1 EA200970121 A1 EA 200970121A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
hydrogen
het
hydroxy
calkyl
Prior art date
Application number
EA200970121A
Other languages
English (en)
Other versions
EA014779B1 (ru
Inventor
Александра Папаникос
Эдди Жан Эдгар Фрейн
Петер Тен Холтэ
Марк Виллемс
Вернер Констант Йохан Эмбрехтс
Лоранс Анн Мевеллек
Пьер-Анри Сторк
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200970121A1 publication Critical patent/EA200970121A1/ru
Publication of EA014779B1 publication Critical patent/EA014779B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/54—Silicon-containing compounds
    • C08K5/544—Silicon-containing compounds containing nitrogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I), их N-оксидным формам, фармацевтически приемлемым аддитивным солям и стереохимически изомерным формам, где Y означает -С-алкил-, -С-алкил-NR-С-алкил- или -С-алкил-HR-СО-С-алкил-; Xозначает -О-; Xозначает NR-С-алкил; Rозначает водород, галоген или Het-O-; Rозначает водород; Rозначает гидроксигруппу, C-алкилоксигруппу или C-алкилоксигруппу, замещенную одним или двумя заместителями, каждый из которых независимо выбран из Het, гидроксигруппы, C-алкилоксигруппы, С-алкилокси-С-алкилоксигруппы и NRR; Rозначает водород или C-алкил; Rозначает водород или C-алкил; Rозначает водород; Rи R, каждый независимо, означают водород, C-алкил-S(=O)-Салкил-С(=O)-; C-алкил или C-алкил, замещенный гидроксигруппой; Hetозначает пиридинил, необязательно замещенный C-алкилом; Hetозначает морфолинил, пиперидинил или пиперазинил, причем указанный Hetнеобязательно замещен гидрокси-С-алкилом или C-алкил-S(=O)-Салкилом.
EA200970121A 2006-07-13 2007-07-12 Производные хиназолина в качестве mtki EA014779B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06117185 2006-07-13
PCT/EP2007/057200 WO2008006884A2 (en) 2006-07-13 2007-07-12 Mtki quinazoline derivatives

Publications (2)

Publication Number Publication Date
EA200970121A1 true EA200970121A1 (ru) 2009-06-30
EA014779B1 EA014779B1 (ru) 2011-02-28

Family

ID=37814194

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970121A EA014779B1 (ru) 2006-07-13 2007-07-12 Производные хиназолина в качестве mtki

Country Status (13)

Country Link
US (1) US8492377B2 (ru)
EP (1) EP2044084B1 (ru)
JP (2) JP2009542778A (ru)
CN (1) CN101490060B (ru)
AU (1) AU2007274284B2 (ru)
BR (1) BRPI0714211B8 (ru)
CA (1) CA2654583C (ru)
DK (1) DK2044084T3 (ru)
EA (1) EA014779B1 (ru)
ES (1) ES2569428T3 (ru)
HK (1) HK1132994A1 (ru)
MX (1) MX2009000456A (ru)
WO (1) WO2008006884A2 (ru)

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JP4936897B2 (ja) 2003-12-18 2012-05-23 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗増殖剤としてのピリド−およびピリミドピリミジン誘導体
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CA2693715C (en) 2007-07-27 2015-10-27 Janssen Pharmaceutica Nv Pyrrolopyrimidines
CN102127087B (zh) * 2011-01-21 2012-07-04 江苏先声药物研究有限公司 喹唑啉衍生物
WO2017044623A1 (en) 2015-09-09 2017-03-16 Lau Warren C Methods, compositions, and uses of novel fyn kinase inhibitors

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Also Published As

Publication number Publication date
JP2009542778A (ja) 2009-12-03
US8492377B2 (en) 2013-07-23
DK2044084T3 (en) 2016-05-09
EA014779B1 (ru) 2011-02-28
WO2008006884A3 (en) 2008-03-06
JP5744127B2 (ja) 2015-07-01
CN101490060B (zh) 2012-04-11
EP2044084B1 (en) 2016-02-17
CA2654583A1 (en) 2008-01-17
EP2044084A2 (en) 2009-04-08
HK1132994A1 (en) 2010-03-12
ES2569428T3 (es) 2016-05-10
CA2654583C (en) 2015-11-24
CN101490060A (zh) 2009-07-22
BRPI0714211B8 (pt) 2021-05-25
MX2009000456A (es) 2009-01-27
BRPI0714211B1 (pt) 2020-11-17
AU2007274284A1 (en) 2008-01-17
US20100029627A1 (en) 2010-02-04
WO2008006884A2 (en) 2008-01-17
BRPI0714211A2 (pt) 2013-01-01
JP2013249307A (ja) 2013-12-12
AU2007274284B2 (en) 2012-04-26

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