EA200900268A1 - ЭНАНТИОМЕРНОЧИСТЫЕ β-АГОНИСТЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ - Google Patents

ЭНАНТИОМЕРНОЧИСТЫЕ β-АГОНИСТЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ

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Publication number
EA200900268A1
EA200900268A1 EA200900268A EA200900268A EA200900268A1 EA 200900268 A1 EA200900268 A1 EA 200900268A1 EA 200900268 A EA200900268 A EA 200900268A EA 200900268 A EA200900268 A EA 200900268A EA 200900268 A1 EA200900268 A1 EA 200900268A1
Authority
EA
Eurasian Patent Office
Prior art keywords
enantiomerna
agonists
cleaner
production
medicinal means
Prior art date
Application number
EA200900268A
Other languages
English (en)
Inventor
Инго Конетцки
Петер Зигер
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200900268A1 publication Critical patent/EA200900268A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

В заявке описаны энантиомерночистые соединения формулы (1) в которой остатки R, Rи R, индекс m и символ Yмогут иметь указанные в формуле изобретения и в описании изобретения значения, а также описаны способ получения таких соединений и их применение в качестве лекарственных средств, прежде всего в качестве лекарственных средств для лечения заболеваний дыхательных путей.
EA200900268A 2006-08-22 2007-08-21 ЭНАНТИОМЕРНОЧИСТЫЕ β-АГОНИСТЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ EA200900268A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06119273 2006-08-22
PCT/EP2007/058654 WO2008023004A1 (de) 2006-08-22 2007-08-21 Enantiomerenreine betaagonisten, verfahren zu deren herstellungen und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
EA200900268A1 true EA200900268A1 (ru) 2009-08-28

Family

ID=38698758

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900268A EA200900268A1 (ru) 2006-08-22 2007-08-21 ЭНАНТИОМЕРНОЧИСТЫЕ β-АГОНИСТЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ

Country Status (22)

Country Link
US (1) US7709474B2 (ru)
EP (1) EP2057134A1 (ru)
JP (1) JP2010501522A (ru)
KR (1) KR20090043586A (ru)
CN (1) CN101506182A (ru)
AR (1) AR062476A1 (ru)
AU (1) AU2007287537A1 (ru)
BR (1) BRPI0715690A2 (ru)
CA (1) CA2661143A1 (ru)
CO (1) CO6150169A2 (ru)
EA (1) EA200900268A1 (ru)
EC (1) ECSP099082A (ru)
IL (1) IL197124A0 (ru)
MX (1) MX2009001515A (ru)
NO (1) NO20090101L (ru)
NZ (1) NZ575567A (ru)
PE (1) PE20080610A1 (ru)
TW (1) TW200817347A (ru)
UA (1) UA96951C2 (ru)
UY (1) UY30550A1 (ru)
WO (1) WO2008023004A1 (ru)
ZA (1) ZA200810829B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010501520A (ja) * 2006-08-22 2010-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 光学異性的に純粋なベータ作動薬を含む吸入用粉末製剤
PE20080425A1 (es) * 2006-08-22 2008-06-16 Boehringer Ingelheim Int Formulacion aerosol para la inhalacion de beta-agonistas
JP2010529155A (ja) 2007-06-13 2010-08-26 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 出血性疾患の治療及び予防的処置における血管外投与のためのｖｗｆ安定化ｆｖｉｉｉ製剤及びｆｖｉｉｉなしのｖｗｆ製剤の使用
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
ES2657291T3 (es) 2013-04-22 2018-03-02 Csl Ltd. Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro

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US4460581A (en) * 1982-10-12 1984-07-17 Boehringer Ingelheim Kg (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
US4570630A (en) * 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
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IL107120A (en) 1992-09-29 1997-09-30 Boehringer Ingelheim Int Atomising nozzle and filter and spray generating device
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US5495054A (en) 1994-05-31 1996-02-27 Sepracor, Inc. Tetrahydroindeno[1,2-D][1,3,2]oxazaboroles and their use as enantioselective catalysts
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE19536903C2 (de) 1995-10-04 1998-09-10 Boehringer Ingelheim Int Vorrichtung zum Haltern eines fluidischen Bauteils
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BR0114584A (pt) 2000-10-12 2003-08-26 Boehringer Ingelheim Pharma Monohidrato cristalino, processos para a sua preparação e sua aplicação para a preparação de um medicamento
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DE10203753A1 (de) 2002-01-31 2003-08-14 Boehringer Ingelheim Pharma Neue Xanthencarbonsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
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DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US7220742B2 (en) * 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102005008921A1 (de) * 2005-02-24 2006-08-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von Atemwegserkrankungen
US7423146B2 (en) * 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
PE20080425A1 (es) * 2006-08-22 2008-06-16 Boehringer Ingelheim Int Formulacion aerosol para la inhalacion de beta-agonistas
UY30552A1 (es) * 2006-08-22 2008-03-31 Boehringer Ingelheim Int Combinaciones farmacologiicas en base a derivados sustituidos de la n-(5-{2-[1,1-dimetil-propilamino]-1-hidroxi-metil}-2-hidroxi-fenil)-metansulfonamida y aplicaciones

Also Published As

Publication number Publication date
CN101506182A (zh) 2009-08-12
CA2661143A1 (en) 2008-02-28
US20080070909A1 (en) 2008-03-20
WO2008023004A1 (de) 2008-02-28
NZ575567A (en) 2011-12-22
JP2010501522A (ja) 2010-01-21
NO20090101L (no) 2009-01-29
AU2007287537A1 (en) 2008-02-28
TW200817347A (en) 2008-04-16
MX2009001515A (es) 2009-02-18
ZA200810829B (en) 2009-11-25
CO6150169A2 (es) 2010-04-20
IL197124A0 (en) 2009-11-18
UA96951C2 (ru) 2011-12-26
UY30550A1 (es) 2008-03-31
KR20090043586A (ko) 2009-05-06
US7709474B2 (en) 2010-05-04
AR062476A1 (es) 2008-11-12
PE20080610A1 (es) 2008-07-15
EP2057134A1 (de) 2009-05-13
WO2008023004A8 (de) 2008-05-22
ECSP099082A (es) 2009-02-27
BRPI0715690A2 (pt) 2013-09-17

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