EA200801752A1 - Покрытые энтеросолюбильной оболочкой цистеамин и цистамин и их производные - Google Patents

Покрытые энтеросолюбильной оболочкой цистеамин и цистамин и их производные

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Publication number
EA200801752A1
EA200801752A1 EA200801752A EA200801752A EA200801752A1 EA 200801752 A1 EA200801752 A1 EA 200801752A1 EA 200801752 A EA200801752 A EA 200801752A EA 200801752 A EA200801752 A EA 200801752A EA 200801752 A1 EA200801752 A1 EA 200801752A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cystamine
cysteamine
enterosolobylnyy
derivatives
shell
Prior art date
Application number
EA200801752A
Other languages
English (en)
Other versions
EA023971B1 (ru
Inventor
Ранджан Дохил
Джерри Шнайдер
Original Assignee
Те Риджентс Оф Те Юниверсити Оф Калифорния
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38327943&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200801752(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Те Риджентс Оф Те Юниверсити Оф Калифорния filed Critical Те Риджентс Оф Те Юниверсити Оф Калифорния
Publication of EA200801752A1 publication Critical patent/EA200801752A1/ru
Publication of EA023971B1 publication Critical patent/EA023971B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
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    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P25/00—Drugs for disorders of the nervous system
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Abstract

Открытие предоставляет оральные лекарственные формы цистеамина и цистамина, пригодные для лечения цистиноза и нейродегенеративных болезней и расстройств. Данные лекарственные формы обеспечивают контролируемое высвобождение композиций, которые улучшают качество жизни, и уменьшенные побочные явления.
EA200801752A 2006-01-27 2007-01-26 Применение композиции, содержащей покрытые энтеросолюбильной оболочкой цистамин или цистеамин, для лечения цистиноза и способ лечения цистиноза EA023971B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76271506P 2006-01-27 2006-01-27
PCT/US2007/002325 WO2007089670A2 (en) 2006-01-27 2007-01-26 Enterically coated cysteamine, cystamine and derivatives thereof

Publications (2)

Publication Number Publication Date
EA200801752A1 true EA200801752A1 (ru) 2008-12-30
EA023971B1 EA023971B1 (ru) 2016-08-31

Family

ID=38327943

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201600089A EA201600089A1 (ru) 2006-01-27 2007-01-26 Покрытые энтеросолюбильной оболочкой цистеамин и цистамин и их производные
EA200801752A EA023971B1 (ru) 2006-01-27 2007-01-26 Применение композиции, содержащей покрытые энтеросолюбильной оболочкой цистамин или цистеамин, для лечения цистиноза и способ лечения цистиноза

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201600089A EA201600089A1 (ru) 2006-01-27 2007-01-26 Покрытые энтеросолюбильной оболочкой цистеамин и цистамин и их производные

Country Status (20)

Country Link
US (15) US8026284B2 (ru)
EP (3) EP2535044B1 (ru)
AU (1) AU2007210005C1 (ru)
BR (1) BRPI0707277B1 (ru)
CA (1) CA2640531C (ru)
CY (1) CY1122943T1 (ru)
DK (2) DK1919458T6 (ru)
EA (2) EA201600089A1 (ru)
ES (2) ES2388310T7 (ru)
FR (1) FR14C0018I1 (ru)
HU (1) HUE049307T2 (ru)
IL (1) IL193044A (ru)
LT (1) LT2535044T (ru)
LU (1) LU92389I2 (ru)
MX (1) MX2008009647A (ru)
NL (1) NL300649I2 (ru)
PL (2) PL2535044T3 (ru)
PT (2) PT1919458E (ru)
SI (2) SI2535044T1 (ru)
WO (1) WO2007089670A2 (ru)

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ITUA20161799A1 (it) 2016-03-18 2017-09-18 Recordati Ind Chimica E Farmaceutica S P A Composizione farmaceutica a rilascio prolungato comprendente cisteamina o un suo sale
EP3308773A1 (en) 2016-10-11 2018-04-18 Recordati Industria Chimica E Farmaceutica SPA Formulations of cysteamine and cysteamine derivatives
US11576871B2 (en) 2016-11-16 2023-02-14 The Regents Of The University Of California Formulations of cysteamine and cystamine
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EP3684309A4 (en) * 2017-09-22 2021-06-09 University of Florida Research Foundation DEVICES AND METHODS FOR REDUCING CYSTINE CRYSTALS IN VIVO
WO2020198529A1 (en) 2019-03-26 2020-10-01 The Regents Of The University Ofcalifornia Substituted amino-thiol and amino-disulfide compounds, and uses thereof
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